achalasia Clinical Trials

21 recruitingLast updated: May 13, 2026

There are 21 actively recruiting achalasia clinical trials across 12 countries. Studies span Not Applicable, Phase 3, Phase 4, Phase 2. Top locations include Hong Kong, Hong Kong, Beijing, Beijing Municipality, China, Cairo, Egypt. Updated daily from ClinicalTrials.gov.


achalasia Trials at a Glance

21 actively recruiting trials for achalasia are listed on ClinicalTrialsFinder across 6 cities in 12 countries. The largest study group is Not Applicable with 8 trials, with the heaviest enrollment activity in Hong Kong, Beijing, and Cairo. Lead sponsors running achalasia studies include Chinese University of Hong Kong, Baylor College of Medicine, and Asian Institute of Gastroenterology, India.

Browse achalasia trials by phase

Treatments under study

About achalasia Clinical Trials

Looking for clinical trials for achalasia? There are currently 11 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new achalasia trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about achalasia clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 21 trials

Recruiting

Clinical Outcomes, Safety, and Effectiveness of Speedboat UltraSlim™ in Per-Oral Endoscopic Myotomy (POEM)

achalasiaEsophageal Motility Disorders
Baylor College of Medicine40 enrolled1 locationNCT07496840
Recruiting
Not Applicable

Artificial Intelligence-Guided Detection of Blood Vessels to Enhance Safety in Third-Space Endoscopic Procedures

TumorAchalasia Cardia
Asian Institute of Gastroenterology, India20 enrolled1 locationNCT07399652
Recruiting

Esophageal Cancer Risk Registry

Esophageal CancerEsophageal DiseasesEsophageal Achalasia+2 more
University of Pittsburgh7,000 enrolled1 locationNCT00260585
Recruiting

PRospective Registry of Esophageal Motility

achalasiaeosinophilic esophagitisEsophageal Diseases+2 more
IRCCS San Raffaele10,000 enrolled1 locationNCT07506746
Recruiting
Phase 2Phase 3

Effectiveness of Methods for Pyloric Drainage in esophagecTomY: Botox vs. Pyloromyotomy

EsophagectomyEsophageal Cancer SurgeryDelayed Gastric Emptying Following Procedure+4 more
The Cleveland Clinic170 enrolled1 locationNCT06721520
Recruiting
Not Applicable

Safety and Efficacy of a Novel SpydrBlade Flexible Bipolar in POEM

achalasiaEGJ Outflow Obstruction
Chinese University of Hong Kong73 enrolled2 locationsNCT07406945
Recruiting
Not Applicable

Routine Versus Symptomatic Protein Pump Inhibitor Therapy for Prevention of Gastroesophageal Reflux After Per Oral Endoscopic Myotomy for Esophageal Achalasia

Esophageal Achalasia
Centre Hospitalier Universitaire de Nīmes132 enrolled4 locationsNCT05899842
Recruiting

Prospective Evaluation of the Clinical Utility of Peroral Endoscopic Myotomy for Gastrointestinal Motility Disorders

achalasiaZenker DiverticulumGastroparesis+2 more
AdventHealth600 enrolled1 locationNCT05905016
Recruiting
Not Applicable

Assessment of Different Modified POEM for Achalasia

Esophageal Achalasia
Peking Union Medical College Hospital52 enrolled1 locationNCT04578769
Recruiting

Effects of Malnutrition on Respiratory and Renal Functions in Patients Undergoing Peroral Endoscopic Myotomy (POEM)

Esophageal Achalasia
Umraniye Education and Research Hospital60 enrolled1 locationNCT06405412
Recruiting
Phase 4

Comprehensive Esophageal Diagnostics Study

achalasia
Emory University80 enrolled2 locationsNCT04641702
Recruiting

The Use of Indocyanine Green Fluorescence (ICG) During Laparoscopic Heller- Dor

achalasiaIndocyanine Green (ICG)Indocyanine Green+1 more
Federico II University70 enrolled1 locationNCT07181070
Recruiting
Not Applicable

Evolution of the Chicago Classification: Bridging Physiology and Mechanics

DysphagiaIneffective Esophageal MotilityAchalasia, Esophageal
Northwestern University575 enrolled1 locationNCT06883175
Recruiting

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford

Multiple Endocrine Neoplasia Type 1Multiple Endocrine Neoplasia Type 2Rare Disorders+337 more
Sanford Health20,000 enrolled2 locationsNCT01793168
Recruiting
Phase 4

VZV in the Enteric Nervous System: Pathogenesis and Consequences

achalasia
Vanderbilt University Medical Center40 enrolled1 locationNCT05550194
Recruiting
Phase 3

Electrosurgical Modes for Endoscopic Submucosal Dissection in Peroral Endoscopic Esophageal Myotomy

achalasiaAchalasia Cardia
Cairo University52 enrolled1 locationNCT06189859
Recruiting
Not Applicable

POEM-F for Achalasia International Study

achalasia
Chinese University of Hong Kong81 enrolled7 locationsNCT06042127
Recruiting

MARIMPACH : Contribution of High-resolution Manometry With Impedancemetry for the Evaluation of Esophageal Clearance in Achalasia

Esophageal Achalasia
University Hospital, Bordeaux104 enrolled1 locationNCT06230536
Recruiting
Not Applicable

Effect of Botulinum Toxin Injection Guided by Ultrasound Combined With Balloon Localization on Cricopharyngeal Achalasia

DysphagiaCricopharyngeal Achalasia
The First Affiliated Hospital of Zhengzhou University20 enrolled1 locationNCT06213662
Recruiting

Analysis of Prevalence and Risk Factors Associated With Gastroesophageal Reflux Disease and Esophagitis After Peroral Endoscopic Myotomy

achalasiaGERD
Maria Sklodowska-Curie National Research Institute of Oncology100 enrolled1 locationNCT05080634