Phase 1 Alzheimer Clinical Trials
58 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 58 trials
Recruiting
Phase 1
PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)
HealthyMild Cognitive ImpairmentAlzheimer s Disease
National Institute of Mental Health (NIMH)90 enrolled1 locationNCT07169630
Recruiting
Phase 1
A Study to Evaluate ALN-5288 in Patients With Alzheimer's Disease
Alzheimer s Disease
Alnylam Pharmaceuticals50 enrolled13 locationsNCT07214727
Recruiting
Phase 1
AV-1980R (Tau Vaccine) in Preclinical Alzheimer's Disease (TAURUS-1980)
Alzheimer DiseasePreclinical Alzheimer's Disease
Institute for Molecular Medicine48 enrolled5 locationsNCT07158905
Recruiting
Phase 1
A Study of LY3439539 in Participants With Alzheimer's Disease
Alzheimer Disease
Eli Lilly and Company30 enrolled9 locationsNCT07598370
Recruiting
Phase 1
A Study to Evaluate the Safety and Tolerability of ALN-APP in Patients With EOAD
Early-Onset Alzheimer Disease
Alnylam Pharmaceuticals60 enrolled8 locationsNCT05231785
Recruiting
Phase 1Phase 2
A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)
Alzheimer s DiseaseBeta-AmyloidProdromal Alzheimer's Disease+2 more
AC Immune SA304 enrolled26 locationsNCT05462106
Recruiting
Phase 1
SAD Study of CGB3002 in Healthy Participants
Alzheimer s Disease
ChainGen Biopharma Ltd46 enrolled1 locationNCT07660341
Recruiting
Phase 1Phase 2
Low-Dose Radiotherapy for Alzheimer's Disease
DementiaAlzheimer DementiaAlzheimer Dementia (AD)+2 more
Evan Thomas50 enrolled1 locationNCT07693140
Recruiting
Phase 1
PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
DementiaALSMild Cognitive Impairment+2 more
National Institute of Mental Health (NIMH)184 enrolled1 locationNCT04396873
Recruiting
Phase 1Phase 2
Clinical Study of SNK01 in Participants With Moderate Alzheimer's Disease
Moderate Alzheimer Disease
NKGen Biotech, Inc.36 enrolled8 locationsNCT06189963
Recruiting
Phase 1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL628 in Participants With Early Alzheimer's Disease
Alzheimer Disease, Early Onset
Denali Therapeutics Inc.68 enrolled4 locationsNCT07328451
Recruiting
Phase 1
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7812653 in Participants With Early Symptomatic Alzheimer's Disease (eAD)
Alzheimer s Disease
Hoffmann-La Roche50 enrolled10 locationsNCT07234942
Recruiting
Phase 1Phase 2
A Study to Assess the Safety and Effects of ABBV-1758 Following Subcutaneous or Intravenous Injections in Participants With Alzheimer's Disease
Alzheimer s Disease
AbbVie210 enrolled11 locationsNCT07599670
Recruiting
Phase 1Phase 2
Study of ARO-MAPT-SC in Healthy Participants and Participants With Early Alzheimer's Disease
Alzheimer DiseaseAlzheimer Disease, Early Onset
Arrowhead Pharmaceuticals112 enrolled3 locationsNCT07221344
Recruiting
Phase 1Phase 2
Allogeneic Adipose Tissue Derived-stem Cells in Alzheimer Disease
Alzheimer Disease
University Hospital, Toulouse9 enrolled1 locationNCT07367815
Recruiting
Phase 1Phase 2
Interleukine-2 (IL-2) Plus Semaglutide in Alzheimer's Disease
Alzheimer Dementia (AD)
The Methodist Hospital Research Institute30 enrolled1 locationNCT07651319
Recruiting
Phase 1
A Study of LY4006895 in Healthy Participants With Early Symptomatic Alzheimer's Disease (AD)
HealthyAlzheimer Disease
Eli Lilly and Company128 enrolled13 locationsNCT06657768
Recruiting
Phase 1
UAB Alzheimer's Disease Center Core Cohort - Tau Imaging Substudy
Alzheimer Disease
University of Alabama at Birmingham160 enrolled1 locationNCT03809351
Recruiting
Phase 1
TREAD: Time Restricted Eating Intervention for Alzheimer's Disease
Alzheimer DiseaseMild Cognitive ImpairmentAlzheimer s Disease
University of California, San Diego60 enrolled1 locationNCT06548191
Recruiting
Phase 1Phase 2
The Effect of CB-Exo-A600 in Mild to Moderate Alzheimer's Disease
Mild to moderate Alzheimer's disease
Xuanwu Hospital, Beijing33 enrolled1 locationNCT07457125