Replacement Clinical Trials

191 recruitingLast updated: June 20, 2026

There are 191 actively recruiting replacement clinical trials across 56 countries. Studies span Not Applicable, Phase 4, Phase 3, Phase 2, Early Phase 1. Top locations include Bologna, Italy, Beijing, Beijing Municipality, China, Bordeaux, France. Updated daily from ClinicalTrials.gov.


Replacement Trials at a Glance

191 actively recruiting trials for replacement are listed on ClinicalTrialsFinder across 6 cities in 56 countries. The largest study group is Not Applicable with 75 trials, with the heaviest enrollment activity in Bologna, Beijing, and Bordeaux. Lead sponsors running replacement studies include Istituto Ortopedico Rizzoli, Insel Gruppe AG, University Hospital Bern, and Symbios Orthopedie SA.

Browse replacement trials by phase

Treatments under study

About Replacement Clinical Trials

Looking for clinical trials for Replacement? There are currently 4 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Replacement trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Replacement clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 191 trials

Recruiting
Not Applicable

Evaluation of the Safety and Effectiveness of CHORDS® Cerebral Protection System During TAVR: DUET Trial

Transcatheter Aortic Valve Replacement (TAVR)Cerebral Vascular Accident (CVA)/Stroke
Resonova (Shanghai) Medtech Limited240 enrolled15 locationsNCT07648693
Recruiting
Not Applicable

Preoperative Fasting and the Gut Microbiome Before Hip Replacement

Surgical wound infectionPostoperative ComplicationsGastrointestinal Microbiome+2 more
Charite University, Berlin, Germany130 enrolled1 locationNCT07651462
Recruiting
Not Applicable

PENG Block + LIA For Endoprosthesis Surgery

anesthesia and analgesiaPain, PostoperativeNerve Block+3 more
ASST Gaetano Pini-CTO100 enrolled1 locationNCT07239817
Recruiting

Transcatheter Mitral and Tricuspid Interventions: a Cardiac Magnetic Resonance Study

Mitral InsufficiencyTranscatheter Aortic Valve Replacement
Centro Cardiologico Monzino250 enrolled1 locationNCT07370467
Recruiting
Not Applicable

Early Versus Delayed Rehabilitation After Reverse Total Shoulder Arthroplasty for Proximal Humerus Fracture

Orthopedic DisorderHumerus fractureSHOULDER ARTHROPLASTY+1 more
University of Virginia10 enrolled1 locationNCT06869343
Recruiting
Not Applicable

INHANCE Stemless Reverse Shoulder IDE

arthroplastyShoulderReplacement
DePuy Orthopaedics168 enrolled19 locationsNCT06323980
Recruiting
Phase 3

Suzetrigine in Total Hip Arthroplasty

Total Hip Replacement SurgeryPainPain Management+13 more
Hospital for Special Surgery, New York210 enrolled1 locationNCT07226700
Recruiting

Prospective Validation of a Pre-Specified Algorithm for the Management of Conduction Disturbances Following TAVR

Transcatheter Aortic Valve ReplacementConduction DisturbancesPermanent Pacemaker Implantation
Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec2,000 enrolled1 locationNCT04139616
Recruiting

Development and Pre-validation of a Machine Learning-based Prediction Algorithm for Early Functional Recovery in Patients Undergoing Hip and Knee Replacement Surgery

Joint ReplacementArtificial Intelligence (AI)Machine Learning+1 more
Istituto Ortopedico Rizzoli943 enrolled2 locationsNCT07333560
Recruiting
Not Applicable

Remote Monitoring After Knee Replacement Surgery

Knee Arthroplasty, TotalKnee Replacement Arthroplasty
Diakonhjemmet Hospital140 enrolled1 locationNCT07003932
Recruiting
Early Phase 1

Replacement of the Native Mitral Valve Using the ReValve System

Mitral Valve Replacement
ReValve Solutions Inc.25 enrolled2 locationsNCT07601269
Recruiting
Not Applicable

Continuous Veno-venous Hemodialysis and Continuous Veno-venous Hemodiafiltration on Urea Reduction Rate in Intensive Care Patient

Continuous renal replacement therapyAcute Kidney InjuryIntensive Care Unit
Centre Hospitalier Universitaire de Nīmes80 enrolled1 locationNCT06369064
Recruiting
Not Applicable

Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE-MAKE)

TemperatureBlood PressureCardiac Arrest (CA)+9 more
Helsinki University Central Hospital3,500 enrolled52 locationsNCT07579390
Recruiting

Abbott Cephea Mitral Valve Disease Registry

Mitral RegurgitationMitral StenosisMitral Valve Disease+4 more
Abbott Medical Devices1,000 enrolled22 locationsNCT07069673
Recruiting
Not Applicable

Coronary Artery Disease Assessment Strategies in TAVI Patients

Coronary Artery DiseaseTranscatheter Aortic Valve ReplacementHeart Disease Risk Factors
Insel Gruppe AG, University Hospital Bern546 enrolled1 locationNCT06559332
Recruiting
Not Applicable

Comparison of Pain Relief Methods for Hip Surgery: A Study on Two Different Nerve Block Techniques

Pain, PostoperativeNerve BlockOpioid Consumption, Postoperative+4 more
Başakşehir Çam & Sakura City Hospital52 enrolled1 locationNCT06821516
Recruiting

Outcomes of Surgical Treatment Using a Custom-made Device for Total Ankle and Talar Replacement in the Management of Severe Cases of Bone Loss or Bone Compromise: a Pilot Study.

Ankle ArthritisArthrosisAnkle replacement
Istituto Ortopedico Rizzoli26 enrolled1 locationNCT07569848
Recruiting
Not Applicable

Binaural Beats for Postoperative Pain and Anxiety Reduction

AnxietyTotal Hip Arthroplasty (THA)Total Knee Replacement+6 more
University of Miami50 enrolled1 locationNCT07437469
Recruiting
Not Applicable

Prolonged Chest Tube Treatment to Reduce Rates of Atrial Fibrillation Following Cardiac Surgery

Coronary Arterial Disease (CAD)Valve ReplacementAortic Surgery
Region Skane624 enrolled1 locationNCT06800781
Recruiting
Not Applicable

Optimizing a Remote-based Physical Activity Intervention for Adults With Total Knee Replacement

knee replacement
University of South Carolina336 enrolled1 locationNCT06768762