Atrial Fibrillation (Paroxysmal) Clinical Trials

13 recruitingLast updated: June 20, 2026

There are 13 actively recruiting atrial fibrillation (paroxysmal) clinical trials across 10 countries. Studies span Not Applicable, Phase 2, Phase 3. Top locations include Athens, Greece, Bilbao, Spain, Brescia, Italy. Updated daily from ClinicalTrials.gov.


Atrial Fibrillation (Paroxysmal) Trials at a Glance

13 actively recruiting trials for atrial fibrillation (paroxysmal) are listed on ClinicalTrialsFinder across 6 cities in 10 countries. The largest study group is Not Applicable with 11 trials, with the heaviest enrollment activity in Athens, Bilbao, and Brescia. Lead sponsors running atrial fibrillation (paroxysmal) studies include Pulse Biosciences, Inc., Cedars-Sinai Medical Center, and CardioFocus.

Browse atrial fibrillation (paroxysmal) trials by phase

Treatments under study

About Atrial Fibrillation (Paroxysmal) Clinical Trials

Looking for clinical trials for Atrial Fibrillation (Paroxysmal)? There are currently 13 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Atrial Fibrillation (Paroxysmal) trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Atrial Fibrillation (Paroxysmal) clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 113 of 13 trials

Recruiting
Not Applicable

The Effect of Pulse Field Ablation on Atrial Mechanics in Catheter Ablation of Paroxysmal Atrial Fibrillation

Atrial Fibrillation (Paroxysmal)
Assistance Publique - Hôpitaux de Paris80 enrolled1 locationNCT06557876
Recruiting
Not Applicable

Biofeedback Intervention for Paroxysmal Atrial Fibrillation

Atrial Fibrillation (Paroxysmal)
Liverpool John Moores University40 enrolled1 locationNCT07454317
Recruiting
Not Applicable

CellFX® Nanosecond Pulsed Field Ablation (PFA) 360 Catheter Ablation System for Treatment of Atrial Fibrillation

Atrial Fibrillation (Paroxysmal)Cardiac ArrhythmiaCardiac Ablation
Pulse Biosciences, Inc.60 enrolled3 locationsNCT06696170
Recruiting
Not Applicable

NS-PFA Catheter Ablation of Paroxysmal Atrial Fibrillation With the Pulse Biosciences CellFX System

Atrial Fibrillation (Paroxysmal)Cardiac ArrhythmiaCardiac Ablation
Pulse Biosciences, Inc.215 enrolled1 locationNCT07018596
Recruiting
Not Applicable

The Effect of a Digital MediYoga Program on Quality of Life, Blood Pressure and Heart Rate Among Patients With Atrial Fibrillation

Quality of LifeAtrial Fibrillation (AF)Mental Health+1 more
Herlev and Gentofte Hospital456 enrolled1 locationNCT07321964
Recruiting
Not Applicable

Full-Avoidance vs. Permissive/Regulated Drinking & Outcomes On Fibrillation

Atrial Fibrillation (AF)Atrial Fibrillation (Paroxysmal)
University of California, San Francisco100 enrolled2 locationsNCT06754176
Recruiting
Not Applicable

Esophageal Temperature During PVI Using Q-DOT Micro

Atrial Fibrillation (Paroxysmal)
Cedars-Sinai Medical Center30 enrolled1 locationNCT06392932
Recruiting
Not Applicable

Pulmonary Vein Isolation With the Single Shot Endoscopic Ultra-Compliant PFA Balloon for the Treatment of AF

Atrial Fibrillation (Paroxysmal)
CardioFocus75 enrolled1 locationNCT06828939
Recruiting
Not Applicable

Value of Screening and Treatment of SAHS in the Management of AF Ablation Candidates

Atrial Fibrillation, PersistentAtrial Fibrillation (Paroxysmal)Apnea Syndrome+1 more
Hospital San Carlos, Madrid50 enrolled1 locationNCT04606693
Recruiting
Not Applicable

Pulsed Field Ablation With Concomitant Radiofrequency Cardioneuroablation in Patients With Paroxysmal Atrial Fibrillation

Atrial Fibrillation (Paroxysmal)
St. Joseph's Centre, Poland20 enrolled1 locationNCT07171463
Recruiting
Phase 3

Flecainide Versus Amiodarone in the Cardioversion of Paroxysmal Atrial Fibrillation at the Emergency Department, in Patients With Coronary Artery Disease Without Residual Ischemia

Atrial Fibrillation (Paroxysmal)Coronary Artery Disease Without Residual Ischemia
Hippocration General Hospital80 enrolled3 locationsNCT05549752
Recruiting
Not Applicable

Wide-Antral Pulmonary Vein Isolation in Atrial Fibrillation Ablation with a Single-shot Technique (WIDER-PVI)

Atrial FibrillationAtrial Fibrillation (Paroxysmal)
Hospital Universitario 12 de Octubre440 enrolled17 locationsNCT06698159
Recruiting
Phase 2

RiLuzole to Reduce Atrial FIb Study Using Holter Monitoring

Atrial Fibrillation (Paroxysmal)
University of Utah78 enrolled1 locationNCT05292209