Phase 1 Cirrhosis Clinical Trials
14 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–14 of 14 trials
Recruiting
Phase 1
The Phase 1, Open-label, PET Trial Designed to Investigate the Effect of AZD2389 on FAP Occupancy in the Liver in Participants With Advanced Liver Fibrosis.
Hepatic CirrhosisLiver Fibrosis
AstraZeneca12 enrolled2 locationsNCT07069725
Recruiting
Phase 1Phase 2
EUS Guided Portal-systemic Pressure Gradient Measurement
CirrhosisPortal Hypertension
Chinese University of Hong Kong30 enrolled1 locationNCT04633356
Recruiting
Phase 1
Direct Oral Anticoagulants (Rivaroxaban and Apixaban) in Patients With Liver Cirrhosis
Liver Cirrhosis
Insel Gruppe AG, University Hospital Bern24 enrolled1 locationNCT04874428
Recruiting
Phase 1
Hepatic Impairment With Cirrhosis Due to Cholestatic Liver Disease
CirrhosisCholestatic Liver DiseaseHepatic Impairment
Zydus Therapeutics Inc.30 enrolled1 locationNCT05045482
Recruiting
Phase 1Phase 2
Clinical Study of Human Umbilical Cord Mesenchymal Stem Cells Injection in Patients With Decompensated Hepatitis B Cirrhosis
Decompensated Hepatitis B Cirrhosis
Beijing Tuohua Weiye Biotechnology Co., Ltd.76 enrolled1 locationNCT07413549
Recruiting
Phase 1Phase 2
RTX001 Autologous Engineered Macrophages for Liver Cirrhosis
Liver DiseasesCirrhosis, LiverDecompensated Liver Cirrhosis+5 more
Resolution Therapeutics Limited30 enrolled14 locationsNCT06823713
Recruiting
Phase 1
The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) Trial
Liver DiseasesCirrhosis, LiverLiver Failure
University of Chicago24 enrolled1 locationNCT06871111
Recruiting
Phase 1
Single and Multiple Dose Escalation of PHIN-214 in Child-Pugh A and B Liver Cirrhotics
Cirrhosis, LiverLiver FibrosisAscites Hepatic
PharmaIN74 enrolled9 locationsNCT05490888
Recruiting
Phase 1Phase 2
CRISPR-Edited HLA Donor Liver Transplant to Reduce Rejection
Liver CancerLiver MetastasesLiver Cirrhosis+4 more
AMERICAN ORGAN TRANSPLANT AND CANCER RESEARCH INSTITUTE LLC90 enrolled1 locationNCT07053488
Recruiting
Phase 1
Effect of Hepatic Impairment on the Pharmacokinetics and Safety of VIR-2218 and VIR-3434
CirrhosisHepatic Impairment
Vir Biotechnology, Inc.144 enrolled5 locationsNCT05484206
Recruiting
Phase 1Phase 2
Intestinal Microbiota Transplant in Alcohol-Associated Liver Disease
CirrhosisAlcohol Use DisorderLiver Disease; Alcohol-Related
Virginia Commonwealth University80 enrolled2 locationsNCT05548452
Recruiting
Phase 1
A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple- Ascending Dose Study to Evaluate the Safety and Tolerability of OLX75016 in Healthy Volunteers and Patients with Non-Alcoholic Fatty Liver Disease.
CirrhosisFibrosis
OliX AU Pty Ltd40 enrolled1 locationACTRN12624001111561
Completed
Phase 1
A first in human study to Evaluate the Safety and Tolerability of OLX75016 for treatment of nonalcoholic steatohepatitis (NASH) and liver fibrosis.
(NAFLD) to steatohepatitis (NASH)Cirrhosis
OliX AU Pty Ltd58 enrolled1 locationACTRN12624000023550
Completed
Phase 1
A Phase 1 Single and Multiple Ascending Dose Study to Assess the Safety and Pharmacokinetics of SZN-043, a Novel Bispecific Fusion Protein Targeting ASGR1 and ZNRF3/RNF43, in Healthy Volunteers and Subjects with Liver Cirrhosis
Alcoholic HepatitisLiver Cirrhosis
Surrozen Operating, Inc.40 enrolled1 locationACTRN12622000392763