Claudication Clinical Trials

22 recruitingLast updated: May 21, 2026

There are 22 actively recruiting claudication clinical trials across 12 countries. Studies span Not Applicable, Phase 2, Phase 3, Early Phase 1, Phase 1. Top locations include Chicago, Illinois, United States, Pittsburgh, Pennsylvania, United States, Oslo, Norway. Updated daily from ClinicalTrials.gov.


Claudication Trials at a Glance

22 actively recruiting trials for claudication are listed on ClinicalTrialsFinder across 6 cities in 12 countries. The largest study group is Not Applicable with 14 trials, with the heaviest enrollment activity in Chicago, Pittsburgh, and Oslo. Lead sponsors running claudication studies include Northwestern University, University of Oklahoma, and Louis Messina.

Browse claudication trials by phase

About Claudication Clinical Trials

Looking for clinical trials for Claudication? There are currently 7 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Claudication trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Claudication clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 22 trials

Recruiting
Not Applicable

Local And Systemic Macrophage Activation in Coronary and Peripheral Artery Disease

intermittent claudicationstable coronary artery diseaseAcute Coronary Syndromes+1 more
Maria Cecilia Hospital60 enrolled1 locationNCT07588295
Recruiting
Not Applicable

Red Light Treatment in Peripheral Artery Disease

Peripheral Artery DiseaseVasodilationClaudication, Intermittent
University of Alabama at Birmingham40 enrolled1 locationNCT03203239
Recruiting
Phase 3

MetfOrmin BenefIts Lower Extremities With Intermittent Claudication

intermittent claudication
VA Office of Research and Development200 enrolled1 locationNCT05132439
Recruiting
Not Applicable

The Effects of Diet and Exercise Interventions in Peripheral Artery Disease

ClaudicationPeripheral Artery Disease
University of Oklahoma150 enrolled1 locationNCT03845036
Recruiting
Phase 2

Fisetin to Reduce Senescence and Mobility Impairment in PAD

ClaudicationPeripheral Arterial DiseaseAging+2 more
Northwestern University34 enrolled1 locationNCT06399809
Recruiting

Presence of Dural Pulsation in Patients Diagnosed With Lumbar Spinal Stenosis

ClaudicationDisability PhysicalMagnetic Resonance+2 more
Marmara University100 enrolled1 locationNCT07233798
Recruiting
Not Applicable

Contribution of Optical Coherence Tomography in the Endovascular Treatment of Femoral Occlusions

ClaudicationSuperficial Femoral Artery StenosisIschemic Leg
University Hospital, Lille166 enrolled1 locationNCT04434586
Recruiting

CRUSH PAD: Real-world Outcomes Following Use of Shockwave Intravascular Lithotripsy (IVL) Technology in Calcified Common Femoral Lesions

ClaudicationPeripheral Arterial DiseaseFemoral Arterial Calcification+1 more
Yale University50 enrolled2 locationsNCT05145478
Recruiting
Not Applicable

Motivating Physical Activity With Behavioural interVention and Electrical Stimulation Remotely in Intermittent Claudication

intermittent claudicationPeripheral Artery Disease
Glasgow Caledonian University48 enrolled1 locationNCT06114732
Recruiting
Phase 3

Improving Mobility After Revascularization in Peripheral Artery Disease

intermittent claudicationMobility LimitationPeripheral Artery Disease+2 more
Northwestern University386 enrolled7 locationsNCT06686121
Recruiting
Not Applicable

Passive Calf Stretching Therapy in Peripheral Artery Disease

Peripheral Artery DiseaseClaudication, Intermittent
Penn State University24 enrolled1 locationNCT06041880
Recruiting
Phase 2

Response to Exercise and Nitric Oxide in PAD

intermittent claudicationExercisePeripheral Artery Disease+1 more
Northwestern University200 enrolled2 locationsNCT06657976
Recruiting
Not Applicable

Personalised Multicomponent Exercise Programme in Peripheral Arterial Disease

intermittent claudicationPeripheral Arterial Disease
University of Trás-os-Montes and Alto Douro40 enrolled3 locationsNCT06410521
Recruiting
Not Applicable

The Effects of a Novel, Non-ischemic and Pain-free Exercise Intervention in Peripheral Artery Disease

ClaudicationPeripheral Artery Disease
University of Oklahoma100 enrolled1 locationNCT05712395
Recruiting
Not Applicable

Exercise Training Study of Patients With Claudicatio Intermittens

Claudication, Intermittent
Norwegian University of Science and Technology100 enrolled14 locationsNCT06448390
Recruiting
Not Applicable

Supervised Exercise-based Rehabilitation for People With Intermittent Claudication in Denmark

intermittent claudication
Slagelse Hospital600 enrolled1 locationNCT06299956
Recruiting
Phase 1

The Effects of ATLAS Therapy on Nitric Oxide Bioavailability in Patients With Intermittent Claudication

Peripheral Vascular DiseasesPeripheral Artery DiseaseClaudication, Intermittent
Louis Messina10 enrolled1 locationNCT04800692
Recruiting
Not Applicable

Additional Hyperbaric Oxygen After Lower Extremity Amputation

OsteomyelitisDiabetes MellitusAmputation+6 more
Oslo University Hospital120 enrolled2 locationsNCT03594344
Recruiting
Not Applicable

Home-based Exercice Therapy for Patients With Intermittent Claudication Using a New Smartphone Application

intermittent claudication
CHU de Reims52 enrolled1 locationNCT05457738
Recruiting
Not Applicable

Study of the R3 Vascular Drug-Eluting Bioresorbable Scaffold in Treating Below the Knee Arterial Disease

Peripheral Arterial DiseaseAtherosclerotic LesionLower Extremity Ischemia+1 more
R3 Vascular Inc.30 enrolled7 locationsNCT04912323