Comfort Clinical Trials

54 recruitingLast updated: June 18, 2026

There are 54 actively recruiting comfort clinical trials across 22 countries. Studies span Not Applicable, Phase 4, Phase 2. Top locations include San Francisco, California, United States, Beijing, Beijing Municipality, China, Amiens, France. Updated daily from ClinicalTrials.gov.


Comfort Trials at a Glance

54 actively recruiting trials for comfort are listed on ClinicalTrialsFinder across 6 cities in 22 countries. The largest study group is Not Applicable with 32 trials, with the heaviest enrollment activity in San Francisco, Beijing, and Amiens. Lead sponsors running comfort studies include Brien Holden Vision Institute, The University of Sydney, and Ankara Yildirim Beyazıt University.

Browse comfort trials by phase

Treatments under study

About Comfort Clinical Trials

Looking for clinical trials for Comfort? There are currently 6 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Comfort trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Comfort clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 54 trials

Recruiting
Not Applicable

Refitting Satisfied INFUSE One-Day Multifocal Wearers to DAILIES TOTAL1 Multifocal Contact Lenses

PresbyopiaContact Lens Comfort and Successful Refitting
Gordon Schanzlin New Vision30 enrolled1 locationNCT07638943
Recruiting
Not Applicable

J-Tip Use for Paracentesis in Adults With Ascites

Evaluate Patient Comfort Level During Paracentesis by Numbing Skin With a Needle-less Device, Instead of Using a Needle to Numb the Skin
Northwestern University110 enrolled1 locationNCT06996379
Recruiting
Not Applicable

Effect of Yoga and Values Clarification on Stress, Comfort, and Emotional Regulation in Parents of Children With Special Needs

StressEmotional RegulationComfort
Ankara Yildirim Beyazıt University66 enrolled1 locationNCT07628569
Recruiting
Not Applicable

Effects of Rectal Indomethacin Suppository on Postoperative CRBD in Patients Undergoing LRP

Prostate Cancer (Post Prostatectomy)Perioperative AnestheticCatheter-related Bladder Discomfort (CRBD)
Zhejiang University130 enrolled1 locationNCT07607990
Recruiting
Not Applicable

Compliance With PROMs Detection Through Digital Support and Correlation Compared Standard to Outpatient Detection in Knee Prosthetics

Knee DiscomfortApproach-Approach Conflict
Istituto Ortopedico Rizzoli50 enrolled1 locationNCT04752761
Recruiting
Not Applicable

Comparison of Patient-reported Pain After Initial Archwire Placement

Pain, OrofacialOrthodontic Discomfort
University of Colorado, Denver126 enrolled1 locationNCT03906422
Recruiting
Not Applicable

NT-II™ Collagen for Joint Discomfort and Function

Joint DiscomfortActivity-Related Knee DiscomfortFunctional Joint Pain+2 more
Hofseth Biocare ASA120 enrolled1 locationNCT07119645
Recruiting
Not Applicable

Comfort Intervention in PICU Children

Anxiety in childrenSleepFear+2 more
Ankara Yildirim Beyazıt University86 enrolled1 locationNCT07441668
Recruiting
Not Applicable

Evaluation of the Synergistic Effect of Combining a Prebiotic and a Postbiotic on Intestinal Discomfort

Intestinal DiscomfortAbdominal Pain/ Discomfort
Université Catholique de Louvain140 enrolled1 locationNCT07420231
Recruiting
Not Applicable

Exercise in Patients With Hypermobile Joints and Knee Pain

Hypermobility SyndromeKnee DiscomfortHypermobility, Joint
University of Southern Denmark90 enrolled2 locationsNCT06277401
Recruiting
Not Applicable

Efficacy of LcS-Fermented Milk on Constipation-Related Symptoms in Filipino Adults

Gastrointestinal DiscomfortConstipation
University of Santo Tomas60 enrolled1 locationNCT07083596
Recruiting
Not Applicable

The Impact of Image-Assisted Colonoscope on Patient Experience, Physician Workload, and Examination Quality

Colorectal Cancer ScreeningColonic Polyps/Colonoscopy/Colorectal NeoplasmsDifficult Colonoscopy+1 more
DONG WU200 enrolled1 locationNCT07541924
Recruiting
Not Applicable

Examining Olive Oil Extract on Knee Comfort and Function

Healthy Adult MaleJoint DiscomfortHealthy Adult Females
Applied Food Sciences Inc.168 enrolled1 locationNCT07514013
Recruiting

Quality Improvement Project to Reduce Preoperative Fasting Times Before Elective Procedures

DeliriumPreoperative FastingPostoperative Nausea and Vomiting (PONV)+2 more
University of Giessen1,000 enrolled1 locationNCT07488468
Recruiting

Tolerance, Use and Performance of the PEASY Urine Collection Device in Hospitalized Patients

Urinary IncontinenceMedical Device Discomfort
Centre Hospitalier Universitaire de Nīmes20 enrolled1 locationNCT07028996
Recruiting
Not Applicable

THE EFFECT OF REIKI ON BREASTFEEDING, PAIN AND COMFORT AFTER CESAREAN SECTION

Postpartum CarePostpartum ComfortBreastfeeding Self-Efficacy+5 more
Saglik Bilimleri Universitesi99 enrolled1 locationNCT07447609
Recruiting
Not Applicable

Assessing the Effects of Cool Roofs on Indoor Environments and Health

Sleep QualityDepressionDehydration+22 more
Aditi Bunker3,200 enrolled5 locationsNCT06579950
Recruiting
Not Applicable

Comparison of Outpatient Rehabilitation Versus Self-training for the Treatment and Prevention of Postpartum Pelvic Floor Dysfunction

Pelvic Floor DysfunctionPostpartum CarePostpartum Comfort+3 more
Vilnius University80 enrolled1 locationNCT07426770
Recruiting
Not Applicable

Evaluation of Gut-Related Well-Being and Mood Effects of a Daily Nutritional Food Ingredient From the Co-Fermentation of Fungal Mycelium (Pleurotus Pulmonarius) and Microalgae (Chlorella Vulgaris)

Gastrointestinal DiscomfortDigestive Well BeingGut-related Symptoms
Koralo GmbH80 enrolled1 locationNCT07407777
Recruiting
Not Applicable

EVALUATION OF THE EFFECT OF ACTIVE WARMING APPLIED TO THE MOTHER DURING CESAREAN SECTION ON POST-BREASTFEEDING OUTCOMES: A RANDOMIZED CONTROLLED STUDY

thermal comfortBreastfeedingCesarean Resection
Kutahya Health Sciences University68 enrolled1 locationNCT07331168