Comorbidities Clinical Trials

35 recruitingLast updated: June 18, 2026

There are 35 actively recruiting comorbidities clinical trials across 24 countries. Studies span Not Applicable, Phase 3, Phase 2. Top locations include Paris, France, Milan, Italy, Barcelona, Spain. Updated daily from ClinicalTrials.gov.


Comorbidities Trials at a Glance

35 actively recruiting trials for comorbidities are listed on ClinicalTrialsFinder across 6 cities in 24 countries. The largest study group is Not Applicable with 13 trials, with the heaviest enrollment activity in Paris, Milan, and Barcelona. Lead sponsors running comorbidities studies include Assistance Publique - Hôpitaux de Paris, Centre Hospitalier Universitaire, Amiens, and Aphaia Pharma US LLC.

Browse comorbidities trials by phase

Treatments under study

About Comorbidities Clinical Trials

Looking for clinical trials for Comorbidities? There are currently 6 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Comorbidities trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Comorbidities clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 35 trials

Recruiting

Access to Kidney Transplant of Obese Patients Beginning Dialysis

Obese PatientsComorbiditiesDialysis+1 more
Centre Hospitalier Universitaire, Amiens100 enrolled1 locationNCT04748770
Recruiting
Phase 2Phase 3

Evaluating Smoking Cessation Interventions for PWH in South Africa

Comorbidities and Coexisting ConditionsSmoking CessationHIV
Johns Hopkins University660 enrolled1 locationNCT05413122
Recruiting

BRAZILIAN REGISTRY OF CHRONIC NON-COMMUNICABLE DISEASES IN PEOPLE LIVING WITH HIV/AIDS

CancerChronic Kidney DiseaseCardiovascular and Cerebrovascular Diseases+2 more
Hospital Alemão Oswaldo Cruz743 enrolled9 locationsNCT07118683
Recruiting
Phase 3

COMMODITIES Trial: Initial Dual Oral Therapy vs Monotherapy in PAH With Cardiovascular Comorbidities

ComorbiditiesCardiovascular Disease (CVD)Pulmonary Arterial Hypertension PAH
Assistance Publique - Hôpitaux de Paris186 enrolled1 locationNCT07245680
Recruiting
Not Applicable

Spatial Scene Recognition Memory in Epilepsy Surgery

Medically refractory epilepsyMemory deficitsMemory Disorders+9 more
University of California, Davis620 enrolled2 locationsNCT07580183
Recruiting

Exploring Multimorbidity in Patients With Spinal Pain

Comorbidities and Coexisting ConditionsBack PainNeck Pain
Jacob Christiansen Gandløse2,000 enrolled1 locationNCT06402409
Recruiting

The Cancer Stage Shifting Initiative: Registry and Biorepository to Research and Address Health Disparities in Cancer Care

CancerCancer Comorbidities
National Minority Quality Forum100,000 enrolled2 locationsNCT07461493
Recruiting

Esketamine Nasal Spray in Real-World Settings in Treatment-Resistant Depression

AnxietyAnhedoniaCognition+5 more
Riccardo Guglielmo100 enrolled5 locationsNCT07146503
Recruiting
Phase 3

Efficacy and Safety of Tirzepatide Once Weekly Versus Placebo in Participants Who Are Either Obese or Overweight With Weight-Related Comorbidities (SURMOUNT-1)

ObesityOverweight (Without Type 2 Diabetes) With Weight-related Comorbidities
Hudson Biotech2,539 enrolled1 locationNCT07481747
Recruiting
Not Applicable

Human Immunodeficiency Virus (HIV) Food Insecurities

Type 2 Diabetes Mellitus (T2DM)PrediabetesHIV+2 more
Wake Forest University Health Sciences200 enrolled1 locationNCT04943861
Recruiting
Not Applicable

Streamlined Geriatric and Oncological Evaluation Based On IC Technology

Breast CancerColorectal, CancerProstate Cancer+2 more
Institut Bergonié720 enrolled10 locationsNCT05720910
Recruiting
Phase 3

A Study of IBI362 in Chinese Adolescents With Obesity or Overweight

Adolescents With Obesity or Overweight With Weight-Related Comorbidities
Innovent Biologics (Suzhou) Co. Ltd.180 enrolled1 locationNCT07255209
Recruiting
Not Applicable

Tailored Stapled SADI-S: Initial Report and Preliminary Results

Bariatric SurgeryMalnutritionComorbidities+1 more
El-Sahel Teaching Hospital40 enrolled1 locationNCT07289555
Recruiting

Headache Registration and Followup Initiated by Tongji Hospital, HUST

ComorbiditiesHeadache
Tongji Hospital50,000 enrolled1 locationNCT07269561
Recruiting
Not Applicable

Comorbidity Management in Rheumatic Disease.

Comorbidities and Coexisting ConditionsRheumatoid Arthritis
Western University, Canada199 enrolled1 locationNCT06579222
Recruiting
Not Applicable

Association of a Digital Signature of Physical Activity and Sedentary Lifestyle With the Development of Multimorbidities in Chronic Diseases (eMOB)

ExerciseComorbidities and Coexisting ConditionsSedentary Behavior+4 more
University Hospital, Clermont-Ferrand700 enrolled1 locationNCT05578495
Recruiting
Phase 2

A Study to Investigate the Efficacy and Safety of Two Different Doses of Twice Daily Distal Jejunal-release Dextrose Beads Formulations Combined With a Gel Composition Compared to Placebos in Obese Subjects With Weight Related Comorbidities

Obese Patients (BMI ≥ 30 kg/m²)Obese With Comorbidities
Aphaia Pharma US LLC102 enrolled6 locationsNCT07008456
Recruiting
Not Applicable

Conversion to SADI-S, RYGB or OAGB After Failed Sleeve

Comorbidities and Coexisting ConditionsWeight LossBariatric Surgery Candidate+1 more
General Committee of Teaching Hospitals and Institutes, Egypt234 enrolled1 locationNCT05608772
Recruiting

Association of POCD With Circulating Biomarkers in Patients Undergoing TUR of Bladder Tumor

Cognitive DeclineUrinary Bladder CancerGeneral Anesthesia+8 more
Osijek University Hospital42 enrolled1 locationNCT07165236
Recruiting

Frailty in Outpatient Digestive Endoscopy

Comorbidities and Coexisting ConditionsComplicationFrailty
Parc de Salut Mar1,474 enrolled1 locationNCT06507527