Critically Ill Patients Clinical Trials

24 recruitingLast updated: May 13, 2026

There are 24 actively recruiting critically ill patients clinical trials across 14 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3. Top locations include Leuven, Belgium, Graz, Austria, Haifa, Israel. Updated daily from ClinicalTrials.gov.


Critically Ill Patients Trials at a Glance

24 actively recruiting trials for critically ill patients are listed on ClinicalTrialsFinder across 6 cities in 14 countries. The largest study group is Not Applicable with 4 trials, with the heaviest enrollment activity in Leuven, Graz, and Haifa. Lead sponsors running critically ill patients studies include Assistance Publique - Hôpitaux de Paris, Intensive Care Unit, John Hunter Hospital, and Universitaire Ziekenhuizen KU Leuven.

Browse critically ill patients trials by phase

Treatments under study

About Critically Ill Patients Clinical Trials

Looking for clinical trials for Critically Ill Patients? There are currently 10 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Critically Ill Patients trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Critically Ill Patients clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 24 trials

Recruiting
Not Applicable

Reliability of Minimally Trained Operator's Velocity-Time Integral Measurement Guided by Artificial Intelligence VTI

Critically Ill PatientsVelocity-time Integral MeasurementTissue Hypoperfusion
Assistance Publique - Hôpitaux de Paris100 enrolled3 locationsNCT06486467
Recruiting
Not Applicable

Stepwise Enteral Nutritional Algorithm and Patient Outcomes in Pediatric Intensive Care Units

enteral nutritionEnteral Nutrition FeedingEnteral Nutrition Intolerance in Critically Ill Patients
Ain Shams University80 enrolled1 locationNCT07307027
Recruiting

Disease Severity, Mortality Risk, and Muscle Function in Intensive Care Unit Patients

Critically Ill Patients
Istinye University45 enrolled1 locationNCT07124442
Recruiting
Not Applicable

Reaching a Caloric Goal Using a Gastric Sonar Versus Aspiration of Gastric Contents in Critically Ill Patients Receiving Nasogastric Enteral Nutrition

Enteral Nutrition Intolerance in Critically Ill Patients
Meir Medical Center50 enrolled1 locationNCT06557629
Recruiting
Phase 2

Pulse Study: Peripheral Use of Low-dose Vasopressors for Safety and Efficacy in the Intensive Care Unit

Central venous catheterizationShockPeripheral Venous Catheterization+1 more
Kingston Health Sciences Centre50 enrolled1 locationNCT06920173
Recruiting

Secondary Sclerosis Cholangitis Prospective

Secondary Sclerosis Cholangitis in Critically Ill Patients
Medical University of Graz380 enrolled1 locationNCT03566797
Recruiting

Clearance of Vasoactive Metabolites With Blood Purification

Critically Ill Patients
Assistance Publique - Hôpitaux de Paris30 enrolled3 locationsNCT06109142
Recruiting

the Multi-modal Evaluation of Agitation in Critically Ill Patients Based on Remote Video-Ultra-sensitive Detection Wave

Critically Ill Patients
Second Affiliated Hospital, School of Medicine, Zhejiang University580 enrolled2 locationsNCT06543602
Recruiting

Impact of Capillary Leak and Hypoalbuminemia on PK/PD of Anidulafungin and Caspofungin in Critically Ill Patients

Critically Ill Patients
Universitaire Ziekenhuizen KU Leuven60 enrolled1 locationNCT04045366
Recruiting

Pharmacokinetics of Liposomal Amphotericin B in Critically Ill vs. Non-critically Ill Hematological Patients: Exploration of Covariates

Critically Ill PatientsPharmacokineticsLiposomal Amphotericin B
Universitaire Ziekenhuizen KU Leuven60 enrolled1 locationNCT03529617
Recruiting
Not Applicable

Intensive Versus Conventional Hyperglycemic Control in Hospitalized Non-critically Ill Patients

Diabetes MellitusNon-critically Ill Patients
Rabin Medical Center600 enrolled2 locationsNCT03510078
Recruiting

Continuous Subcutaneous Glucose Monitoring in Critical Patients

DiabetesHyperglycemiaHypoglycemia+2 more
Universidad Europea de Madrid245 enrolled1 locationNCT06234787
Recruiting

A pilot multicenter randomized study comparing an approach of individualized blood pressure targets to standard care among critically ill patients with shock

Critically ill patients with shock
Intensive Care Unit, John Hunter Hospital50 enrolled5 locationsACTRN12618000571279
Recruiting

A feasibility study comparing an approach of individualized blood pressure targets to standard care among critically ill patients with shock

Critically ill patients with shockRelative hypotension
Intensive Care Unit, John Hunter Hospital60 enrolled2 locationsACTRN12617001459314
Recruiting

Comparing glucose control in the critically ill patient through two methods - conventional insulin sliding scale as compared to computerised automated insulin delivery ( enhanced model predictive control).

Critically ill patients admitted to the intensive care unit with blood glucose > 8.9mmol/l
University Malaya60 enrolled1 locationACTRN12616001450404
Recruiting
Phase 3

The SuDDICU Study of Antibiotic Prophylaxis in Critical Illness

Known or suspected infection in critically ill patients in the Intensive Care Unit (ICU)
The George Institute for Global Health15,000 enrolled18 locationsACTRN12615000411549
Recruiting

Right Ventricular Clearance Index (RVCI): A Simple New Parameter To Assess The Right Ventricular Systolic Function Using Contrast Echocardiography In Critically Ill Patients

Right Ventricular Dysfunction Assessment In Critically Ill Patients
Military Hospital Of Tunis35 enrolled1 locationACTRN12613001339741
Recruiting
Phase 2

Feasibility and safety of conservative versus liberal oxygen targets in the mechanically ventilated patients.

Critically ill patients requiring invasive mechanical ventilation
John Hunter100 enrolled4 locationsACTRN12613000505707
Recruiting

Analgesic, Sedative and Antibiotic Pharmacokinetics during Extracorporeal Membrane Oxygenation: Understanding altered pharmacokinetics to improve patient outcomes.

Alterations to the pharmacokinetics of broad spectrum antibiotics (ceftriaxone, cefepime, meropenem, gentamicin, ciprofloxacin, ticarcillin-clavulanate, piperacillin-tazobactum, vancomycin, linezolid, caspofungin, fluconazole, voriconazole, oseltamivir/oseltamivir carboxylate) in critically ill patients receiving ECMO.Alterations to the pharmacokinetics of sedative and analgesic drugs and their metabolites (morphine - morphine 3 glucorunide, morphine 6 glucuronide, midazolam - 1 and 4 hydroxy midazolam, fentanyl - norfentanyl, dexmedetiomedine, propofol, thiopentone) in critically ill patients receiving ECMO.
Critical Care Research Group160 enrolled4 locationsACTRN12612000559819
Recruiting

Continuous glucose monitoring in ICU

blood glucose control in critically ill patients
University of Canterbury80 enrolled1 locationACTRN12612000130864