Phase 1 Dementia Clinical Trials
26 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 26 trials
Recruiting
Phase 1
PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
DementiaParkinson's Disease
National Institute of Mental Health (NIMH)184 enrolled1 locationNCT04396873
Recruiting
Phase 1Phase 2
A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN)
Frontotemporal DementiaFTDDementia, Frontotemporal+1 more
AviadoBio Ltd18 enrolled19 locationsNCT06064890
Recruiting
Phase 1Phase 2
Rifaximin SSD in Dementia Trial
Dementia Alzheimer TypeDementia Associated With Cerebrovascular Disease
Jasmohan Bajaj20 enrolled1 locationNCT06718686
Recruiting
Phase 1
[18F]F-DOPA Imaging in Patients With Autonomic Failure
Multiple System AtrophyParkinson DiseaseDementia With Lewy Bodies+2 more
Daniel Claassen40 enrolled1 locationNCT04246437
Recruiting
Phase 1
Exploration of an Online Education Program to Support Caregivers' Knowledge Transfer
Dementia
Texas Christian University60 enrolled2 locationsNCT07377331
Recruiting
Phase 1Phase 2
Deep Repetitive Transcranial Magnetic Stimulation (rTMS) of the Precuneus for Alzheimer Disease (AD)
Alzheimer DiseaseAlzheimer&Amp;Amp;#39;s DiseaseDementia Alzheimer Type+4 more
University of California, Los Angeles54 enrolled1 locationNCT06597942
Recruiting
Phase 1
Innate Immunity Stimulation Via TLR9 in Early AD
Mild Cognitive ImpairmentAlzheimer Dementia
NYU Langone Health18 enrolled1 locationNCT05606341
Recruiting
Phase 1
A Trial to Test Intermittent Deep Brain Stimulation of Nucleus Basalis of Meynert to Treat Alzheimers.
Alzheimer Dementia (AD)
Augusta University12 enrolled1 locationNCT07218081
Recruiting
Phase 1Phase 2
A Study of PBFT02 in Participants With FTD and Mutations in the Granulin Precursor (GRN) or C9ORF72 Genes
Frontotemporal DementiaFTDFTD-GRN
Passage Bio, Inc.30 enrolled10 locationsNCT04747431
Recruiting
Phase 1
A Robot-assisted Tailored Activity Programme for People With Dementia and Their Caregivers
DementiaPhysical ActivityCaregiver
The Hong Kong Polytechnic University60 enrolled1 locationNCT07239869
Recruiting
Phase 1
Door-Through-Door Companion Rideshare Technology for Individuals With Alzheimer's Disease and Related Dementias (AD/ADRD)
DementiaCognitive DeclineAlzheimer Disease or Associated Disorder
Onward Health, Inc120 enrolled1 locationNCT06850870
Recruiting
Phase 1Phase 2
Phase 2 Trial of Tributyrin in People With Parkinson's Disease and Cognitive Impairments
Parkinson DiseaseParkinson Disease Dementia
Prabesh Kanel45 enrolled1 locationNCT07154511
Recruiting
Phase 1Phase 2
Ferritin and Iron Burden in SAH sIRB
DementiaSAH
Duke University66 enrolled2 locationsNCT03754725
Recruiting
Phase 1Phase 2
Assess Fibrin in Brains With AD/ADRD
Alzheimer DiseaseDementia of Alzheimer Type
Massachusetts General Hospital30 enrolled1 locationNCT05336695
Recruiting
Phase 1
Veri-T: A Trial of Verdiperstat in Patients With svPPA Due to TDP-43 Pathology
Semantic Dementia
Peter Ljubenkov, MD64 enrolled5 locationsNCT05184569
Recruiting
Phase 1
Safety Of Nrtis for Alzheimer's Therapeutic Advancement in Singapore Study
Mild Cognitive Impairment (MCI)Alzheimer Dementia (AD)
National University Hospital, Singapore48 enrolled1 locationNCT07210528
Recruiting
Phase 1Phase 2
SV2A & TSPO PET Imaging Measures to Reveal Mechanisms of HIV Neuropathogenesis During Antiretroviral Therapy
HealthyHIV Associated Neurocognitive DisorderHIV Dementia+1 more
Yale University70 enrolled1 locationNCT05586581
Recruiting
Phase 1Phase 2
The Effect of Repetitive Transcranial Magnetic Stimulation on Cognitive Improvement in Dementia With Lewy Bodies
Dementia With Lewy Bodies
Korea University Anam Hospital10 enrolled1 locationNCT07122908
Recruiting
Phase 1
Repurposing Nucleoside Reverse Transcriptase Inhibitors for Treatment of AD
Alzheimer Disease, Early OnsetMild Cognitive ImpairmentModerate Dementia
Butler Hospital35 enrolled2 locationsNCT04500847
Recruiting
Phase 1Phase 2
First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia
DementiaAlzheimer DiseaseFrontotemporal Dementia
David Wilson102 enrolled1 locationNCT05374278