Phase 1 Diabetes Mellitus Clinical Trials
60 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 60 trials
Recruiting
Phase 1
A Clinical Study Comparing the Relative Bioavailability and Safety of SHR-3167 Injection
Diabetes Mellitus
Jiangsu HengRui Medicine Co., Ltd.60 enrolled1 locationNCT07489482
Recruiting
Phase 1
Investigating How NNC0487-0111 Regulates Insulin of Adults With Type 2 Diabetes
Diabetes Mellitus
Novo Nordisk A/S80 enrolled1 locationNCT07535307
Recruiting
Phase 1Phase 2
A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM
Type 2 Diabetes Mellitus (T2DM)Obese or Overweight Healthy Volunteers
Alnylam Pharmaceuticals144 enrolled20 locationsNCT06845202
Recruiting
Phase 1
A Study to Evaluate the Effect of Fasting Duration and Tirzepatide Withholding on the Amount of Food and Fluid in the Stomach in Participants With Type 2 Diabetes Mellitus and Participants With Overweight or Obesity Without Type 2 Diabetes Mellitus
ObesityDiabetes Mellitus, Type 2Overweight
Eli Lilly and Company40 enrolled1 locationNCT07299084
Recruiting
Phase 1
Phase I Study to Evaluate the Pharmacokinetics and Safety After Co-administration of L03RD1 and L03RD2 or Administration of L03TD1 in Healthy Volunteers
Type 2 Diabetes Mellitus (T2DM)
Celltrion48 enrolled1 locationNCT07533539
Recruiting
Phase 1Phase 2
A First-In-Human Study of ARO-ALK7 in Adults With Obesity With and Without Type 2 Diabetes Mellitus
ObesityDiabetes Mellitus, Type 2
Arrowhead Pharmaceuticals138 enrolled8 locationsNCT06937203
Recruiting
Phase 1
A Study of GNTI-122 in Adults Recently Diagnosed With T1D
Type 1 Diabetes MellitusType 1 Diabetes (T1D)
GentiBio, Inc16 enrolled10 locationsNCT06919354
Recruiting
Phase 1
Cellular Therapy for Type 1 Diabetes Using Mesenchymal Stem Cells
Diabetes Mellitus, Type 1
Medical University of South Carolina60 enrolled1 locationNCT04061746
Recruiting
Phase 1Phase 2
cfMSC Therapy for Diabetes
Type II Diabetes Mellitus
Shenzhen Geno-Immune Medical Institute30 enrolled1 locationNCT07495956
Recruiting
Phase 1
A Study of REGEND003 on Patients With Type 2 Diabetes Mellitus (T2DM) and Chronic Kidney Disease (CKD)
Type 2 Diabetes Mellitus (T2DM) and Chronic Kidney Disease (CKD)
Regend Therapeutics15 enrolled1 locationNCT07275788
Recruiting
Phase 1
Study to Evaluate if Exposure to Drug is Impacted in Participants With Renal Insufficiency
Type II Diabetes Mellitus
Sun Pharmaceutical Industries Limited40 enrolled3 locationsNCT07385547
Recruiting
Phase 1
A Study to Evaluate the Effect of RO7204239 on Insulin Sensitivity and Muscle Composition in Participants With Type 2 Diabetes Mellitus (T2DM) and Overweight or Obesity
ObesityOverweightType 2 Diabetes Mellitus
Hoffmann-La Roche30 enrolled1 locationNCT07137585
Recruiting
Phase 1
A Study of LY4057996 in Healthy Participants and Participants With Type 1 and Type 2 Diabetes
Diabetes Mellitus, Type 2Diabetes Mellitus, Type 1
Eli Lilly and Company124 enrolled1 locationNCT06945406
Recruiting
Phase 1Phase 2
CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)
Type 1 DiabetesType 1 Diabetes MellitusType 1 Diabetes Mellitis+7 more
COUR Pharmaceutical Development Company, Inc.72 enrolled31 locationsNCT06783309
Recruiting
Phase 1Phase 2
Safety, Tolerability, and Efficacy of Immunomodulation With A Monoclonal Antibody Against CD40L in Combination With Transplanted Islet Cells in Adults With Brittle Type 1 Diabetes Mellitus (T1D)
Type 1 Diabetes Mellitus
University of Chicago70 enrolled1 locationNCT06305286
Recruiting
Phase 1
A Study to Evaluate the Effect of Retatrutide on Insulin Secretion and Insulin Sensitivity in Adult Participants With Type 2 Diabetes Mellitus
Diabetes MellitusInsulin Sensitivity
Eli Lilly and Company95 enrolled1 locationNCT06982859
Recruiting
Phase 1Phase 2
A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus
Metabolic DiseaseDiabetes Mellitus, Type 1Type 1 Diabetes+14 more
Otsuka Pharmaceutical Factory, Inc.13 enrolled1 locationNCT06575426
Recruiting
Phase 1Phase 2
Improving Islet Transplantation Outcomes With Gastrin for Type I Diabetes
Diabetes Mellitus, Type 1
City of Hope Medical Center20 enrolled1 locationNCT03746769
Recruiting
Phase 1
A Study to Evaluate the Effect of AZD6793 on the Pharmacokinetics and Pharmacodynamics of Metformin in Participants With Type 2 Diabetes Mellitus
Type 2 Diabetes Mellitus
AstraZeneca28 enrolled1 locationNCT07433062
Recruiting
Phase 1Phase 2
Safety and Efficacy of CELZ-201 in Patients With Recent Onset Type 1 Diabetes
Diabetes Mellitus, Type 1Type 1 Diabetes
Creative Medical Technology Holdings Inc18 enrolled1 locationNCT05626712