Phase 1 Epilepsy Clinical Trials
28 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 28 trials
Recruiting
Phase 1
Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy
Epilepsy
National Institute of Neurological Disorders and Stroke (NINDS)40 enrolled1 locationNCT02531880
Recruiting
Phase 1
Understanding Ketamine's Dissociative Effects (KD Study)
Epilepsy
Stanford University20 enrolled1 locationNCT04861051
Recruiting
Phase 1
Microelectrode Recordings From the Vagus Nerve in Awake Humans
Epilepsy
University of Minnesota60 enrolled1 locationNCT06016686
Recruiting
Phase 1Phase 2
A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patients With Drug-resistant Epilepsy
EpilepsyDrug Resistant EpilepsySeizures, Focal
NaviFUS Corporation8 enrolled3 locationsNCT06388707
Recruiting
Phase 1Phase 2
AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy
Mesial Temporal Lobe Epilepsy
UniQure Biopharma B.V.12 enrolled18 locationsNCT06063850
Recruiting
Phase 1Phase 2
Tianasen (ASO-GNAO1) for GNAO1-Encephalopathy With Epilepsy and Movement Disorders.
EpilepsyHyperkinesisGNAO1
Pirogov Russian National Research Medical University5 enrolled1 locationNCT07363603
Recruiting
Phase 1Phase 2
A Phase 1/2 Study of NRTX-1001 Neuronal Cell Therapy in Drug-Resistant Bilateral Mesial Temporal Lobe Epilepsy (MTLE)
Epilepsy, Temporal Lobe
Neurona Therapeutics10 enrolled17 locationsNCT06422923
Recruiting
Phase 1
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of ABS-1230 Given Orally Compared With Placebo in Healthy Participants Aged 18 to 55 Years
KCNT1-Related Epilepsy
Actio Biosciences, Inc.74 enrolled1 locationNCT07156201
Recruiting
Phase 1
Study to Evaluate the Relative Bioavailability of a New Formulation of NPT 2042 Soft-Gelatin Capsules Compared to the Original Formulation of NPT 2042
EpilepsyAlzheimer DiseaseEpilepsy Intractable
NeuroPro Therapeutics, Inc.8 enrolled1 locationNCT07222878
Recruiting
Phase 1Phase 2
A Clinical Trial of PRAX-222 in Pediatric Participants With Early Onset SCN2A Developmental and Epileptic Encephalopathy
EpilepsySCN2A-DEE
Praxis Precision Medicines60 enrolled3 locationsNCT05737784
Recruiting
Phase 1
Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics And Pharmacodynamics of SIF001 in Healthy Subjects and in Epilepsy Patients
EpilepsyHealthy Volunteer
Suninflam Inc72 enrolled2 locationsNCT07051629
Recruiting
Phase 1
The Impact of Focused Ultrasound Thalamotomy of the Anterior Nucleus for Focal-Onset Epilepsy on Anxiety
AnxietyMedication-refractory Focal-onset Epilepsy
Ohio State University10 enrolled1 locationNCT05032105
Completed
Phase 1
A 2-part Phase I study to evaluate the safety, tolerability, pharmacokinetics and food effects of AXN-027
Epilepsy
Axonis Australia Pty Ltd80 enrolled1 locationACTRN12624001294549
Not Yet Recruiting
Phase 1
A Study in Healthy Males and Females to Test How Different Doses of OPC-224333 are Tolerated (Arm 1)
Epilepsy
Otsuka Pharmaceutical Development & Commercialization, Inc72 enrolled1 locationACTRN12622000460707
Completed
Phase 1
A Trial in Healthy Participants to Evaluate the Pharmacokinetics, Safety, Tolerability and Food Effects of PRAX-562
Epilepsy
Praxis Precision Medicines120 enrolled1 locationACTRN12620001292965
Completed
Phase 1
A Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Study to Assess the Safety and Pharmacokinetics of CHI-541 among Healthy Participants
Muscle SpasticityPainEpilepsy+1 more
10607410 CANADA INC. DBA Spectrum Therapeutics40 enrolled1 locationACTRN12619001723178
Not Yet Recruiting
Phase 1
A Phase 1 study to evaluate safety and tolerability of ES-481 in healthy volunteers
Epilepsy
ES Therapeutics LLC80 enrolled1 locationACTRN12619001591145
Completed
Phase 1
A Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Study to Assess the Safety and Pharmacokinetics of CHI-936 in Healthy Participants
Muscle SpasticityPainEpilepsy+1 more
10607410 CANADA INC. DBA Spectrum Therapeutics40 enrolled1 locationACTRN12619001450101
Completed
Phase 1
Investigation of the safety, tolerability and pharmacokinetics of Cannabidiol in Healthy Volunteers
Severe Intractable Epilepsy
Victorian State Government24 enrolled1 locationACTRN12618001424291
Completed
Phase 1
A Phase 1, Double-Blind, Placebo-Controlled, Randomized Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Multiple-Ascending Doses of PRAX-114 in Healthy Subjects
Epilepsy
Praxis Precision Medicines Australia Pty Ltd48 enrolled1 locationACTRN12618000650291