Phase 2 Epilepsy Clinical Trials
33 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 33 trials
Recruiting
Phase 2
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Clinical Activity of ABS-1230 in Pediatric Participants With KCNT1-related Epilepsy
KCNT1-Related Epilepsy
Actio Biosciences, Inc.45 enrolled1 locationNCT07600736
Recruiting
Phase 1Phase 2
AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy
Mesial Temporal Lobe Epilepsy
UniQure Biopharma B.V.12 enrolled18 locationsNCT06063850
Recruiting
Phase 2
A Study Evaluating NPT 2042 Versus Placebo in Subjects Aged 16-75 Years With Genetic Generalized Epilepsy (GGE) and Absence Seizures
Epilepsy, GeneralizedEpilepsy, Absence
NeuroPro Therapeutics, Inc.12 enrolled1 locationNCT06769659
Recruiting
Phase 2
Enhanced MRI Imaging in Healthy Participants and Participants With Epilepsy
Epilepsy, Temporal Lobe
University of Alberta50 enrolled1 locationNCT06483061
Recruiting
Phase 2Phase 3
A Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy
Focal Epilepsy
Biohaven Therapeutics Ltd.390 enrolled124 locationsNCT06132893
Not Yet Recruiting
Phase 2
A double-blind, placebo-controlled study to evaluate the safety, tolerability and potential antiseizure activity of adjunctive OV-329 in adult focal epilepsy patients.
Epilepsy
Ovid Therapeutics Australia Pty Ltd60 enrolled8 locationsACTRN12626000488303
Recruiting
Phase 2Phase 3
Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy
Focal Epilepsy
Biohaven Therapeutics Ltd.390 enrolled174 locationsNCT06309966
Recruiting
Phase 2
Safety and Tolerability Study of SPN-817 in Adult Patients With Treatment Resistant Epilepsy
EpilepsySeizures, Epileptic
Supernus Pharmaceuticals, Inc.60 enrolled10 locationsNCT05518578
Recruiting
Phase 1Phase 2
A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patients With Drug-resistant Epilepsy
seizureEpilepsyDrug Resistant Epilepsy+2 more
NaviFUS Corporation8 enrolled3 locationsNCT06388707
Recruiting
Phase 2
A Long-term Study of the Safety and Effectiveness of RAP-219 in Adults With Focal Onset Seizures
seizureEpilepsyRefractory Focal Epilepsy+3 more
Rapport Therapeutics Inc.30 enrolled7 locationsNCT07219407
Recruiting
Phase 2
Stopping TSC Onset and Progression 2B: Sirolimus TSC Epilepsy Prevention Study
EpilepsyTuberous Sclerosis Complex
Darcy Krueger64 enrolled11 locationsNCT05104983
Recruiting
Phase 1Phase 2
Tianasen (ASO-GNAO1) for GNAO1-Encephalopathy With Epilepsy and Movement Disorders.
EpilepsyHyperkinesisGNAO1
Pirogov Russian National Research Medical University5 enrolled1 locationNCT07363603
Recruiting
Phase 1Phase 2
A Phase 1/2 Study of NRTX-1001 Neuronal Cell Therapy in Drug-Resistant Bilateral Mesial Temporal Lobe Epilepsy (MTLE)
Epilepsy, Temporal Lobe
Neurona Therapeutics10 enrolled17 locationsNCT06422923
Recruiting
Phase 2
An Open-label Study to Evaluate Safety, Tolerability, and Efficacy of CB03-154 in Subjects Diagnosed With Epilepsy
Focal Epilepsy
Shanghai Zhimeng Biopharma, Inc.144 enrolled1 locationNCT07238868
Recruiting
Phase 1Phase 2
A Clinical Trial of PRAX-222 in Pediatric Participants With Early Onset SCN2A Developmental and Epileptic Encephalopathy
EpilepsySCN2A-DEE
Praxis Precision Medicines60 enrolled3 locationsNCT05737784
Recruiting
Phase 2
The Efficacy of a Subanesthetic Doses of IV Ketamine in the Treatment Drug Resistant Epilepsy
Refractory EpilepsyMedically refractory epilepsyDrug Resistant Epilepsy
Madeline Fields8 enrolled1 locationNCT05019885
Recruiting
Phase 2
BMB-101 in Absence Epilepsy and DEE
Dravet SyndromeLennox Gastaut SyndromeJeavons Syndrome+1 more
Bright Minds Biosciences Pty Ltd20 enrolled5 locationsNCT06401538
Recruiting
Phase 2
An Open Label Trial to Evaluate the Efficacy and Safety of PRAX-628 in Adults With Focal Onset or Tonic-Clonic Seizures
Focal Onset SeizurePrimary Generalized Epilepsy
Praxis Precision Medicines50 enrolled11 locationsNCT06908356
Recruiting
Phase 2Phase 3
Exogenous Ketone Esters for Drug Resistant Epilepsy
Drug Resistant Epilepsy
Sohag University60 enrolled1 locationNCT05670847
Active
Phase 2
Efficacy And Withdrawal Symptoms in Transition Between Cannabidivarin (CBDV) and Cannabidiol (CBD) in Children with Rett Syndrome and Refractory Epilepsy
Refractory EpilepsyRett Syndrome
Sydney Children's Hospital Network3 enrolled1 locationACTRN12624000948594