Phase 3 Epilepsy Clinical Trials

21 recruitingPhase 3

What is a Phase 3 trial?

Phase 3 trials compare the new treatment against the current standard of care in large groups, often hundreds to thousands of participants. Successful Phase 3 results are typically required for regulatory approval.

Showing 120 of 21 trials

Recruiting
Phase 3

Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1

EpilepsyFocal EpilepsyFocal Seizure
Rapport Therapeutics Inc.333 enrolled3 locationsNCT07563881
Recruiting
Phase 3

Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (EPIC (EPIlepsy Cell Therapy))

Mesial Temporal Lobe Epilepsy
Neurona Therapeutics88 enrolled35 locationsNCT05135091
Recruiting
Phase 3

Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures

EpilepsyFocal EpilepsyFocal Seizure
Rapport Therapeutics Inc.312 enrolled2 locationsNCT07594119
Recruiting
Phase 3

A Study to Evaluate the Safety, Efficacy, and PK of ONO-2017 in Japanese Patients With POS 2 to 17 Year Olds

Partial Epilepsy
Ono Pharmaceutical Co., Ltd.20 enrolled1 locationNCT07594158
Recruiting
Phase 3

Ketogenic Diet for New-Onset Absence Epilepsy

Ketogenic DietingEpilepsy, Absenceabsence epilepsy
Johns Hopkins University40 enrolled1 locationNCT04274179
Recruiting
Phase 2Phase 3

A Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy

Focal Epilepsy
Biohaven Therapeutics Ltd.390 enrolled124 locationsNCT06132893
Recruiting
Phase 2Phase 3

Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy

Focal Epilepsy
Biohaven Therapeutics Ltd.390 enrolled174 locationsNCT06309966
Recruiting
Phase 3

A Study to Test the Long-term Safety and Tolerability of Brivaracetam in Study Participants With Childhood Absence Epilepsy or Juvenile Absence Epilepsy

Childhood Absence EpilepsyJuvenile Absence Epilepsy
UCB Biopharma SRL120 enrolled23 locationsNCT06315322
Recruiting
Phase 3

Double-blind, Randomized Clinical Trial Evaluating the Efficacy and Safety of Vormatrigine in Adults With Focal Seizures

Focal Epilepsy
Praxis Precision Medicines300 enrolled7 locationsNCT07505004
Recruiting
Phase 3

Levetiracetam Three Times Daily in Epilepsy

Epilepsy
Waad Alkathiri120 enrolled1 locationNCT07490769
Recruiting
Phase 3

TAP-GRIN: Interventional Study on Patients With GRIN-related Neurodevelopmental Disorders

EpilepsyNeurodevelopmental Disorder (Diagnosis)GRIN-related Disorders+4 more
Meyer Children's Hospital IRCCS40 enrolled3 locationsNCT07377032
Recruiting
Phase 3

LEvetiracetam to Prevent Seizures in Symptomatic Alzheimer's Disease in Adults With Down Syndrome

EpilepsyAlzheimer DiseaseSeizures+7 more
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau120 enrolled5 locationsNCT07234695
Recruiting
Phase 3

A Study to Test the Safety and Tolerability of Brivaracetam in Children and Adolescents With Seizures

Epilepsy
UCB Biopharma SRL70 enrolled36 locationsNCT04715646
Recruiting
Phase 3

ONO-2017 Study Japanese Patients With Primary Generalized Tonic Clonic Seizures.

Epilepsy, Generalized
Ono Pharmaceutical Co., Ltd.15 enrolled25 locationsNCT06579573
Recruiting
Phase 3

Lemborexant Treatment of Insomnia Linked to Epilepsy

EpilepsySleep
University of Manitoba26 enrolled2 locationsNCT06262594
Recruiting
Phase 2Phase 3

Exogenous Ketone Esters for Drug Resistant Epilepsy

Drug Resistant Epilepsy
Sohag University60 enrolled1 locationNCT05670847
Recruiting
Phase 3

Biperiden Trial for Epilepsy Prevention

Brain Injury Traumatic SevereBrain Injury Traumatic ModeratePost Traumatic Epilepsy
Hospital Sirio-Libanes312 enrolled10 locationsNCT04945213
Terminated
Phase 3

Carisbamate Retention Study (CaReS): Comparative Study on the Long Term Effectiveness, Safety and Tolerability of Carisbamate Compared to Two Other Frequently Prescribed Anti-Epileptic Drugs (AEDs) in Patients With Epilepsy.

Epilepsy Seizures
Ortho-McNeil Janssen Scientific Affairs, LLC600 enrolled19 locationsACTRN12609000600246
Terminated
Phase 3

Open label extension study following a double-blind, randomized, placebo-controlled, multicenter study to assess the efficacy and safety of adjunctive zonisamide in primary generalized tonic-clonic seizures.

Epilepsy
Eisai Ltd154 enrolled12 locationsACTRN12608000516381
Terminated
Phase 3

A double blind, randomised, placebo controlled, multi centre study to assess the efficacy and safety of adjunctive zonisamide in myoclonic seizures associated with idiopathic generalised epilepsy.

Epilepsy
Eisai Ltd.110 enrolled12 locationsACTRN12608000097347