Phase 3 Epilepsy Clinical Trials
21 recruitingPhase 3
What is a Phase 3 trial?
Phase 3 trials compare the new treatment against the current standard of care in large groups, often hundreds to thousands of participants. Successful Phase 3 results are typically required for regulatory approval.
Showing 1–20 of 21 trials
Recruiting
Phase 3
Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1
EpilepsyFocal EpilepsyFocal Seizure
Rapport Therapeutics Inc.333 enrolled3 locationsNCT07563881
Recruiting
Phase 3
Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (EPIC (EPIlepsy Cell Therapy))
Mesial Temporal Lobe Epilepsy
Neurona Therapeutics88 enrolled35 locationsNCT05135091
Recruiting
Phase 3
Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures
EpilepsyFocal EpilepsyFocal Seizure
Rapport Therapeutics Inc.312 enrolled2 locationsNCT07594119
Recruiting
Phase 3
A Study to Evaluate the Safety, Efficacy, and PK of ONO-2017 in Japanese Patients With POS 2 to 17 Year Olds
Partial Epilepsy
Ono Pharmaceutical Co., Ltd.20 enrolled1 locationNCT07594158
Recruiting
Phase 3
Ketogenic Diet for New-Onset Absence Epilepsy
Ketogenic DietingEpilepsy, Absenceabsence epilepsy
Johns Hopkins University40 enrolled1 locationNCT04274179
Recruiting
Phase 2Phase 3
A Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy
Focal Epilepsy
Biohaven Therapeutics Ltd.390 enrolled124 locationsNCT06132893
Recruiting
Phase 2Phase 3
Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy
Focal Epilepsy
Biohaven Therapeutics Ltd.390 enrolled174 locationsNCT06309966
Recruiting
Phase 3
A Study to Test the Long-term Safety and Tolerability of Brivaracetam in Study Participants With Childhood Absence Epilepsy or Juvenile Absence Epilepsy
Childhood Absence EpilepsyJuvenile Absence Epilepsy
UCB Biopharma SRL120 enrolled23 locationsNCT06315322
Recruiting
Phase 3
Double-blind, Randomized Clinical Trial Evaluating the Efficacy and Safety of Vormatrigine in Adults With Focal Seizures
Focal Epilepsy
Praxis Precision Medicines300 enrolled7 locationsNCT07505004
Recruiting
Phase 3
Levetiracetam Three Times Daily in Epilepsy
Epilepsy
Waad Alkathiri120 enrolled1 locationNCT07490769
Recruiting
Phase 3
TAP-GRIN: Interventional Study on Patients With GRIN-related Neurodevelopmental Disorders
EpilepsyNeurodevelopmental Disorder (Diagnosis)GRIN-related Disorders+4 more
Meyer Children's Hospital IRCCS40 enrolled3 locationsNCT07377032
Recruiting
Phase 3
LEvetiracetam to Prevent Seizures in Symptomatic Alzheimer's Disease in Adults With Down Syndrome
EpilepsyAlzheimer DiseaseSeizures+7 more
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau120 enrolled5 locationsNCT07234695
Recruiting
Phase 3
A Study to Test the Safety and Tolerability of Brivaracetam in Children and Adolescents With Seizures
Epilepsy
UCB Biopharma SRL70 enrolled36 locationsNCT04715646
Recruiting
Phase 3
ONO-2017 Study Japanese Patients With Primary Generalized Tonic Clonic Seizures.
Epilepsy, Generalized
Ono Pharmaceutical Co., Ltd.15 enrolled25 locationsNCT06579573
Recruiting
Phase 3
Lemborexant Treatment of Insomnia Linked to Epilepsy
EpilepsySleep
University of Manitoba26 enrolled2 locationsNCT06262594
Recruiting
Phase 2Phase 3
Exogenous Ketone Esters for Drug Resistant Epilepsy
Drug Resistant Epilepsy
Sohag University60 enrolled1 locationNCT05670847
Recruiting
Phase 3
Biperiden Trial for Epilepsy Prevention
Brain Injury Traumatic SevereBrain Injury Traumatic ModeratePost Traumatic Epilepsy
Hospital Sirio-Libanes312 enrolled10 locationsNCT04945213
Terminated
Phase 3
Carisbamate Retention Study (CaReS): Comparative Study on the Long Term Effectiveness, Safety and Tolerability of Carisbamate Compared to Two Other Frequently Prescribed Anti-Epileptic Drugs (AEDs) in Patients With Epilepsy.
Epilepsy Seizures
Ortho-McNeil Janssen Scientific Affairs, LLC600 enrolled19 locationsACTRN12609000600246
Terminated
Phase 3
Open label extension study following a double-blind, randomized, placebo-controlled, multicenter study to assess the efficacy and safety of adjunctive zonisamide in primary generalized tonic-clonic seizures.
Epilepsy
Eisai Ltd154 enrolled12 locationsACTRN12608000516381
Terminated
Phase 3
A double blind, randomised, placebo controlled, multi centre study to assess the efficacy and safety of adjunctive zonisamide in myoclonic seizures associated with idiopathic generalised epilepsy.
Epilepsy
Eisai Ltd.110 enrolled12 locationsACTRN12608000097347