Fatigue Syndrome, Chronic Clinical Trials

11 recruitingLast updated: June 18, 2026

There are 11 actively recruiting fatigue syndrome, chronic clinical trials across 7 countries. Studies span Not Applicable, Early Phase 1, Phase 2. Top locations include Bethesda, Maryland, United States, Boston, Massachusetts, United States, Boulogne-Billancourt, Île-de-France Region, France. Updated daily from ClinicalTrials.gov.


Fatigue Syndrome, Chronic Trials at a Glance

11 actively recruiting trials for fatigue syndrome, chronic are listed on ClinicalTrialsFinder across 6 cities in 7 countries. The largest study group is Not Applicable with 5 trials, with the heaviest enrollment activity in Bethesda, Boston, and Boulogne-Billancourt. Lead sponsors running fatigue syndrome, chronic studies include Centre Medical ISM (Integrative Systemic Medicine), Escuela Universitaria de Fisioterapia de la Once, and Centre Hospitalier Universitaire de Saint Etienne.

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Treatments under study

About Fatigue Syndrome, Chronic Clinical Trials

Looking for clinical trials for Fatigue Syndrome, Chronic? There are currently 11 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Fatigue Syndrome, Chronic trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Fatigue Syndrome, Chronic clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 111 of 11 trials

Recruiting

Photobiomodulation for Chronic Pain and Fatigue in Hypermobile Ehlers-Danlos Syndrome (PBM-SEDh-01)

Chronic PainFatigue Syndrome, ChronicEhlers-Danlos Syndrome, Hypermobile
Centre Medical ISM (Integrative Systemic Medicine)25 enrolled1 locationNCT07637084
Recruiting
Not Applicable

Is Post-exertional Symptom Exacerbation Specific to Patients With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome? A Study Comparing Patients With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome and Patients With Cardiac Diseases Who Underwent an Exercise Test.

Cardiovascular DiseasesFatigue Syndrome, Chronic
Hôpital Européen Marseille80 enrolled1 locationNCT07491315
Recruiting
Early Phase 1

Functional Neuroimaging to Detect the Neural Signatures of the Unpleasantness of Pain and Effort

Fatigue Syndrome, Chronic
National Institute of Neurological Disorders and Stroke (NINDS)47 enrolled1 locationNCT06472622
Recruiting
Not Applicable

Improving Post COVID-19 Syndrome With Hyperbaric Oxygen Treatments

Post COVID-19 ConditionFatigueCOVID-19+3 more
Sunnybrook Health Sciences Centre40 enrolled1 locationNCT06082518
Recruiting

Cognitive Performance, Sleep Disturbances and Fatigue in Multiple Sclerosis

Multiple SclerosisPrimary Progressive Multiple SclerosisRemitting-Relapsing Multiple Sclerosis+3 more
Heinrich-Heine University, Duesseldorf837 enrolled2 locationsNCT07426991
Recruiting
Not Applicable

Research for Pathophysiology of Cancer Related Fatigue (CRF) and Chronic Fatigue (CFS/ME)

Cancer-related FatigueFatigue Syndrome, Chronic
Universität des Saarlandes150 enrolled1 locationNCT03773003
Recruiting

Assessment of Exercise Response in Chronic Fatigue Syndrome / Myalgic Encephalomyelitis.

Fatigue Syndrome, Chronic
Escuela Universitaria de Fisioterapia de la Once22 enrolled1 locationNCT03675087
Recruiting
Phase 2

Testosterone Replacement in Male Cancer Survivors With Fatigue and Low Testosterone

Hypogonadism, MaleFatigue Syndrome, Chronic
Seattle Institute for Biomedical and Clinical Research240 enrolled2 locationsNCT04049331
Recruiting

Chronic Fatigue in the Internal Medicine Outpatient Clinic: a Mixed-methods Quantitative and Qualitative Study

FatigueFatigue SymptomFatigue Syndrome, Chronic
Flevoziekenhuis100 enrolled1 locationNCT06775262
Recruiting
Not Applicable

Effectiveness of Acceptance Commitment Therapy or Micro Breaks in Patients with Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis

Fatigue Syndrome, Chronic
Sarah Schiebler90 enrolled1 locationNCT05168124
Recruiting
Not Applicable

Effects of a Personalized Physical Training to Reduce Fatigue

Fatigue Syndrome, Chronic
Centre Hospitalier Universitaire de Saint Etienne130 enrolled1 locationNCT05899595