Frail Clinical Trials

243 recruitingLast updated: July 11, 2026

There are 243 actively recruiting frail clinical trials across 43 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4, Early Phase 1. Top locations include Singapore, Singapore, Chicago, Illinois, United States, Milan, Italy. Updated daily from ClinicalTrials.gov.


Frail Trials at a Glance

243 actively recruiting trials for frail are listed on ClinicalTrialsFinder across 6 cities in 43 countries. The largest study group is Not Applicable with 125 trials, with the heaviest enrollment activity in Singapore, Chicago, and Milan. Lead sponsors running frail studies include McGill University Health Centre/Research Institute of the McGill University Health Centre, National University of Singapore, and Nova Scotia Health Authority.

Treatments under study

About Frail Clinical Trials

Looking for clinical trials for Frail? There are currently 10 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Frail trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Frail clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 243 trials

Recruiting

Orthopedic Procedures and Postoperative Delirium in Older Adults in the Czech Republic

Hip ArthroplastyOlder AdultsCognitive Impairment+2 more
Tomas Bata Hospital, Czech Republic400 enrolled7 locationsNCT07432009
Recruiting

The Better, Harder, Faster, Stronger Study

Ovarian CancerEndometrial CancerNeoadjuvant Chemotherapy+2 more
Wake Forest University Health Sciences35 enrolled1 locationNCT07220512
Recruiting

Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)

Healthy VolunteersFrailNon-Healthy/Non-Frail
National Institute on Aging (NIA)900 enrolled1 locationNCT02339012
Recruiting
Not Applicable

Resilience Enhancement Using Electronic Frailty Index-Directed Care Pathway

ChemotherapyCancerFrail
Wake Forest University Health Sciences32 enrolled2 locationsNCT07175376
Recruiting
Not Applicable

Perioperative Prehabilitation on Markers of Fitness and Frailty in Patients Undergoing Elective Surgery

Frailty
University of Alberta50 enrolled1 locationNCT05977556
Recruiting
Not Applicable

SAGE-Heart : Senior Assessment fraGility and Post-opErative QALYs 1 Year After Emergency HEART Surgery for Patients Aged 75 and Older

FrailtyCardiac SurgeryQALYs
University Hospital, Bordeaux265 enrolled1 locationNCT07677319
Recruiting

Impact of Auditory Stimulation in Eating Pleasure (EDERE 2021)

AnorexiaFrailtyMalnutrition+2 more
Centre Hospitalier Universitaire de Nice100 enrolled1 locationNCT04923087
Recruiting

Can Serum Lumican Level Identify a Hidden Fragility Phenotype Beyond Bone Mineral Density in Postmenopausal Women?

postmenopausal osteoporosisOsteoporosisFrailty+1 more
Kanuni Sultan Suleyman Training and Research Hospital98 enrolled1 locationNCT07677072
Recruiting
Not Applicable

Non-invasive Brain Stimulation on Functional Capacity in Prefrail Older Adults

Prefrail Elderly
University of Valencia120 enrolled1 locationNCT07346989
Recruiting
Not Applicable

Health Ahead Comparative Effectiveness Study

Cardiovascular DiseasesMetabolic SyndromeCognitive Dysfunction+12 more
William Brandenburg, MD1,000,000 enrolled1 locationNCT07669168
Recruiting
Not Applicable

A Partnered Evaluation to Improve the Identification and Management of Functional Impairment and Frailty Among Older Veterans in Primary Care Settings

FrailtyFunctional Impairment
VA Office of Research and Development10,000 enrolled1 locationNCT06404970
Recruiting
Not Applicable

Effect of Using a Reminder to Encourage Patients to be Active During Their Hospital Stay.

FrailInpatients
Groupe Hospitalier du Havre204 enrolled4 locationsNCT07492745
Recruiting

Preoperative Oral Nutrition And Outcomes In Frail Elderly Patients With Femur Fractures

FrailtyMalnutritionFemoral Fractures
Duzce University228 enrolled1 locationNCT07463352
Recruiting

100-Year Human Aging Study

Disability PhysicalNeoplasmsCardiovascular Diseases+12 more
Longevity Metrics, Inc.1,000,000 enrolled1 locationNCT07563777
Recruiting

Human Observatory Study

Musculoskeletal DiseaseDisability PhysicalNeoplasms+16 more
Longevity Metrics, Inc.1,000,000 enrolled1 locationNCT07646782
Recruiting
Not Applicable

Clinical Efficacy of a Multicomponent Exercise and Comprehensive Geriatric Assessment Program (FRAIL+AP) in Frail Older Adults Within Primary Care: A Randomized Controlled Trial

Frail Elderly
Universidad Europea de Madrid200 enrolled1 locationNCT07643064
Recruiting
Not Applicable

Catheter Ablation Plus LAAO Versus Anticoagulation in Frail Elderly Patients With Atrial Fibrillation

StrokeFrailtyAtrial Fibrillation (AF)+4 more
Guangdong Provincial People's Hospital200 enrolled1 locationNCT07441382
Recruiting
Not Applicable

Assisted Ambulation to Improve Health Outcomes for Older Medical Inpatients

Mobility LimitationFrailtyHospital Acquired Condition+1 more
The Cleveland Clinic3,000 enrolled5 locationsNCT05725928
Recruiting

The Relationship Between Preoperative Anxiety Level and Frailty Score in Elderly Patients Scheduled for Elective Hip Arthroplasty: A Prospective Observational Study

Hip ArthroplastyAnxiety PreoperativeFraility
Başakşehir Çam & Sakura City Hospital142 enrolled1 locationNCT07633483
Recruiting
Not Applicable

Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults

Mobility LimitationCognitive DysfunctionFrail Elderly
University of Florida120 enrolled2 locationsNCT05830942