Frail Clinical Trials

236 recruitingLast updated: June 18, 2026

There are 236 actively recruiting frail clinical trials across 43 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4, Early Phase 1. Top locations include Singapore, Singapore, Chicago, Illinois, United States, Milan, Italy. Updated daily from ClinicalTrials.gov.


Frail Trials at a Glance

236 actively recruiting trials for frail are listed on ClinicalTrialsFinder across 6 cities in 43 countries. The largest study group is Not Applicable with 121 trials, with the heaviest enrollment activity in Singapore, Chicago, and Milan. Lead sponsors running frail studies include McGill University Health Centre/Research Institute of the McGill University Health Centre, National University of Singapore, and Nova Scotia Health Authority.

Treatments under study

About Frail Clinical Trials

Looking for clinical trials for Frail? There are currently 10 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Frail trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Frail clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 236 trials

Recruiting

100-Year Human Aging Study

Disability PhysicalNeoplasmsCardiovascular Diseases+12 more
Longevity Metrics, Inc.1,000,000 enrolled1 locationNCT07563777
Recruiting

Human Observatory Study

Musculoskeletal DiseaseDisability PhysicalNeoplasms+16 more
Longevity Metrics, Inc.1,000,000 enrolled1 locationNCT07646782
Recruiting
Not Applicable

Clinical Efficacy of a Multicomponent Exercise and Comprehensive Geriatric Assessment Program (FRAIL+AP) in Frail Older Adults Within Primary Care: A Randomized Controlled Trial

Frail Elderly
Universidad Europea de Madrid200 enrolled1 locationNCT07643064
Recruiting
Not Applicable

Catheter Ablation Plus LAAO Versus Anticoagulation in Frail Elderly Patients With Atrial Fibrillation

StrokeFrailtyAtrial Fibrillation (AF)+4 more
Guangdong Provincial People's Hospital200 enrolled1 locationNCT07441382
Recruiting
Not Applicable

Assisted Ambulation to Improve Health Outcomes for Older Medical Inpatients

Mobility LimitationFrailtyHospital Acquired Condition+1 more
The Cleveland Clinic3,000 enrolled5 locationsNCT05725928
Recruiting

The Relationship Between Preoperative Anxiety Level and Frailty Score in Elderly Patients Scheduled for Elective Hip Arthroplasty: A Prospective Observational Study

Hip ArthroplastyAnxiety PreoperativeFraility
Başakşehir Çam & Sakura City Hospital142 enrolled1 locationNCT07633483
Recruiting

Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)

Healthy VolunteersFrailNon-Healthy/Non-Frail
National Institute on Aging (NIA)900 enrolled1 locationNCT02339012
Recruiting
Not Applicable

Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults

Mobility LimitationCognitive DysfunctionFrail Elderly
University of Florida120 enrolled2 locationsNCT05830942
Recruiting
Not Applicable

Pharyngeal Exercise (Plus Protein)

Pre-Frail Older Adults
NYU Langone Health120 enrolled2 locationsNCT05963113
Recruiting
Not Applicable

Prehabilitation for Ovarian Cancer Patients

ExerciseOvarian CancerPrehabilitation+4 more
Nova Scotia Health Authority108 enrolled1 locationNCT05364879
Recruiting

Ultrasound, Nutritional Status, and Outcomes in Surgical ICU

FrailtyNutritional StatusMuscle Thickness of the Quadriceps Femoris
Osijek University Hospital50 enrolled1 locationNCT07475767
Recruiting
Not Applicable

The Impact of Geriatric Assessment on the Treatment Plan of Elderly Patients With T2DM

Geriatric AssessmentFrailtyType2diabetes+1 more
Hospital de Clinicas de Porto Alegre220 enrolled1 locationNCT06469437
Recruiting
Not Applicable

Optimizing Prevention of Hospital-Acquired Disability Through Multidomain Interventions

Frailty SyndromeAging
University of Milano Bicocca288 enrolled1 locationNCT06611228
Recruiting
Not Applicable

Resilience Enhancement Using Electronic Frailty Index-Directed Care Pathway

ChemotherapyCancerFrail
Wake Forest University Health Sciences32 enrolled2 locationsNCT07175376
Recruiting

Preoperative Oral Nutrition And Outcomes In Frail Elderly Patients With Femur Fractures

FrailtyMalnutritionFemoral Fractures
Duzce University228 enrolled1 locationNCT07463352
Recruiting
Not Applicable

Investigating the Combined Effects of Protein, Blueberries, and Exercise on Cardiovascular Health and Frailty in Older Nova Scotians

Cardiovascular DiseaseFrailty
Nova Scotia Health Authority240 enrolled1 locationNCT06693271
Recruiting

Frailty in Older Adults With Prostate Cancer: a Prospective Cohort Study

Prostate CancerFrailty at Older Adults
University of Limerick80 enrolled1 locationNCT07605936
Recruiting
Phase 2

Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV

FrailtyAgingHIV-1-infection+2 more
Massachusetts General Hospital100 enrolled2 locationsNCT06554717
Recruiting

Effect of Sarcopenia and Frailty on Rocuronium Pharmacodynamics in Geriatric Patients

SarcopeniaFrailtyNeuromuscular Blockade+2 more
Konya Meram State Hospital100 enrolled1 locationNCT07580144
Recruiting
Phase 2

TCM Formula vs. HMB in Pre-Frail Elders: Muscle Strength and Bone Status

pre frailtySarcopeniaOsteoporosis+2 more
Tri-Service General Hospital90 enrolled1 locationNCT07597850