Phase 1 Gastrointestinal Cancer Clinical Trials
19 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–19 of 19 trials
Recruiting
Phase 1Phase 2
Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients
Pancreatic CancerGastric CancerColon Cancer+2 more
National Cancer Institute (NCI)110 enrolled1 locationNCT03190941
Recruiting
Phase 1Phase 2
Study of Patritumab Deruxtecan in Participants With Gastrointestinal Cancers (MK-1022-011) (HERTHENA-PanTumor02)
Gastrointestinal Cancer
Merck Sharp & Dohme LLC180 enrolled62 locationsNCT06596694
Recruiting
Phase 1Phase 2
Dose-defining Study of Tirapazamine Combined With Embolization in Liver Cancer
Hepatocellular CarcinomaNeuroendocrine TumorsGastrointestinal Cancer Metastatic
Teclison Ltd.25 enrolled2 locationsNCT02174549
Recruiting
Phase 1
Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies
Ovarian CancerPeritoneal CarcinomatosisGastrointestinal Cancer+3 more
National Cancer Institute (NCI)60 enrolled1 locationNCT04847063
Recruiting
Phase 1
Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple Myeloma
Breast CancerOvarian CancerProstate Cancer+6 more
Nammi Therapeutics Inc100 enrolled10 locationsNCT06582017
Recruiting
Phase 1
A Study to Test Different Doses of BI 765049 Alone and in Combination With Ezabenlimab in Asian People With Advanced Cancer (Solid Tumours) Positive for B7-H6
Pancreatic CancerLung CancerGastrointestinal Cancer
Boehringer Ingelheim97 enrolled7 locationsNCT06091930
Recruiting
Phase 1Phase 2
Remote Resistance Exercise Powering Survivors - Gastrointestinal Oncology
Gastrointestinal Cancer
H. Lee Moffitt Cancer Center and Research Institute100 enrolled1 locationNCT05664178
Recruiting
Phase 1
Autologous T-cells Genetically Engineered to Express Receptors Reactive Against KRAS Mutations in Conjunction With a Vaccine Directed Against These Antigens in Participants With Metastatic Cancer
Breast CancerColorectal, CancerOvarian Cancer+4 more
National Cancer Institute (NCI)210 enrolled1 locationNCT06253520
Recruiting
Phase 1
Safety, Tolerance and Preliminary Efficacy of XH001 Injection Combined With Neoantigen Vaccine-induced Tumor-specific T-cell Injection in Advanced Gastrointestinal Cancer
Gastrointestinal Cancer
Beijing GoBroad Hospital18 enrolled1 locationNCT07329894
Recruiting
Phase 1Phase 2
Evaluation of the Preliminary Efficacy and Safety of DR30206 in Combination With Standard Therapy in Patients With Gastrointestinal Cancer
Gastrointestinal Cancer
Zhejiang Doer Biologics Co., Ltd.186 enrolled1 locationNCT07056777
Recruiting
Phase 1
Sacituzumab Govitecan in Combination With Capecitabine for Advanced Gastrointestinal Cancers After Progression on Standard Therapy
Gastrointestinal Cancer
Henry Ford Health System20 enrolled1 locationNCT06065371
Recruiting
Phase 1
A Study of GC203 TIL in Advanced Malignant Solid Tumors
Breast CancerLung CancerSolid Tumor+2 more
Shanghai Juncell Therapeutics18 enrolled1 locationNCT06375187
Recruiting
Phase 1
Neratinib and Fam-Trastuzumab Deruxtecan in Advanced Gastro-esophageal Cancer Patients
Gastric CancerGastrointestinal CancerHER2 Gene Mutation
Fox Chase Cancer Center18 enrolled3 locationsNCT05274048
Recruiting
Phase 1Phase 2
Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 Patients
Pancreatic CancerGastric CancerColon Cancer+2 more
National Cancer Institute (NCI)70 enrolled1 locationNCT03745326
Recruiting
Phase 1Phase 2
Optimizing and Personalising Azacitidine Combination Therapy for Treating Solid Tumours QPOP and CURATE.AI
Breast CancerSolid TumorGastrointestinal Cancer
National University Hospital, Singapore10 enrolled1 locationNCT05381038
Recruiting
Phase 1
Treatment of Cabotamig (ARB202) in Advanced Gastrointestinal Cancer Patients
Liver CancerPancreatic CancerGastric Cancer+6 more
Arbele Pty Ltd68 enrolled3 locationsNCT05411133
Recruiting
Phase 1Phase 2
OH2 Oncolytic Viral Therapy in Solid Tumors
Solid TumorGastrointestinal Cancer
Binhui Biopharmaceutical Co., Ltd.300 enrolled1 locationNCT03866525
Not Yet Recruiting
Phase 1
A study to assess if pantoprazole affects the absorption of capecitabine in patients with breast and gastrointestinal cancers.
Breast CancerGastrointestinal Cancer
Auckland District Health Board20 enrolled1 locationACTRN12620001317987
Completed
Phase 1
Ibudilast for the prevention of nerve symptoms caused by oxalipatin chemotherapy, in patients with metastatic gastrointestinal cancer
Metastatic gastrointestinal cancerAcute neurotoxicity
Concord Cancer Centre20 enrolled1 locationACTRN12618000232235