Phase 1 GBM Clinical Trials
19 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–19 of 19 trials
Recruiting
Phase 1
Sonodynamic Therapy in Patients With Recurrent GBM
GBMGlioblastoma MultiformeRecurrent Glioblastoma
Shayan Moosa, MD11 enrolled1 locationNCT06039709
Recruiting
Phase 1Phase 2
A Phase 1/2 Study of the Safety and Tolerability of MT-125 in GBM Patients
Glioblastoma (GBM)
Myosin Therapeutics Inc.36 enrolled3 locationsNCT07185880
Recruiting
Phase 1Phase 2
Early Phase Study of KESONOTIDE™in Participants With Solid Tumours
Breast CancerLung CancersOvarian Cancer+4 more
Filamon LTD80 enrolled3 locationsNCT06926075
Recruiting
Phase 1Phase 2
5G-PEARL: Paxalisib in Malignant Brain Tumours
Glioblastoma Multiforme (GBM)Malignant Primary Gliomas
Institute of Cancer Research, United Kingdom64 enrolled1 locationNCT07391215
Recruiting
Phase 1
A Study to Evaluate the Safety of a Stem Cell-Based Gene and Cell Therapy in Patients With Newly Diagnosed Glioblastoma
Glioblastoma (GBM)Newly Diagnosed Glioblastoma Multiforme
CHA University10 enrolled1 locationNCT07143812
Recruiting
Phase 1Phase 2
5G-RUBY: Avutometinib and Defactinib in Malignant Brain Tumours
Glioblastoma Multiforme (GBM)Malignant Primary GliomasGlioblastoma Multiform (Grade IV Astrocytoma)+1 more
Institute of Cancer Research, United Kingdom182 enrolled3 locationsNCT06630260
Recruiting
Phase 1
Study of Low-Intensity Focused Ultrasound in Combination With Immunotherapy in Newly Diagnosed Unmethylated Glioblastoma
Glioblastoma (GBM)
University of Virginia12 enrolled1 locationNCT07343986
Recruiting
Phase 1Phase 2
Clinical Study of Oncolytic Virus in Glioblastoma
Glioblastoma (GBM)
Mianyang Central Hospital20 enrolled1 locationNCT07145047
Recruiting
Phase 1
Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.
Brain TumorBrain CancerGlioblastoma+6 more
Henry Ford Health System18 enrolled1 locationNCT05686798
Recruiting
Phase 1
Focused Ultrasound Blood-Brain Barrier Disruption for the Treatment of High-Grade Glioma in Patients Undergoing Standard Chemotherapy
Glioblastoma Multiforme (GBM)GBMGlioma+5 more
Sunnybrook Health Sciences Centre10 enrolled1 locationNCT07179328
Recruiting
Phase 1Phase 2
Clinical Study on the Treatment of Malignant Brain Glioma by QH104 Cell Injection
GBMHigh-Grade GliomasBrain Gliomas
Dushu Lake Hospital Affiliated to Soochow University25 enrolled1 locationNCT06018363
Recruiting
Phase 1
BC008-1A Injection for Recurrent CNS WHO G4 Glioma
GliomaGlioblastoma WHO Grade IVGlioma Tumor Recurrence+2 more
Sichuan Luzhou Buchang Biopharmaceutical Co., Ltd.40 enrolled1 locationNCT06773481
Recruiting
Phase 1
Evaluation of Eflornithine Plus Temozolomide in Patients With Newly Diagnosed Glioblastoma or Astrocytoma
GlioblastomaGBMGlioblastoma Multiforme+4 more
Orbus Therapeutics, Inc.66 enrolled8 locationsNCT05879367
Recruiting
Phase 1
5G-EMERALD: Amivantamab in Malignant Brain Tumours
Glioblastoma Multiforme (GBM)Malignant Primary GliomasGlioblastoma Multiform (Grade IV Astrocytoma)+1 more
Institute of Cancer Research, United Kingdom12 enrolled2 locationsNCT06632236
Recruiting
Phase 1Phase 2
Super-selective Intra-arterial Repeated Infusion of Cetuximab for the Treatment of Newly Diagnosed Glioblastoma
Brain TumorBrain CancerGlioblastoma+4 more
Northwell Health33 enrolled1 locationNCT02861898
Recruiting
Phase 1Phase 2
Oral Capecitabine and Temozolomide (CAPTEM) for Newly Diagnosed GBM
CancerBrain TumorBrain Cancer+6 more
Northwell Health67 enrolled1 locationNCT03213002
Recruiting
Phase 1Phase 2
Study of LP-184 in Patients With Advanced Solid Tumors
Advanced Solid TumorMetastatic Solid TumorTNBC - Triple-Negative Breast Cancer+4 more
Lantern Pharma Inc.175 enrolled9 locationsNCT05933265
Not Yet Recruiting
Phase 1
Valproic acid and Metformin to treat patients with brain tumours
Brain tumours - Glioblastoma multiforme (GBM)
Flinders Centre for Innovation in Cancer, Flinders University/Flinders Medical centre12 enrolled1 locationACTRN12612001050842
Completed
Phase 1
Phase I Trial of Dendritic Cell Vaccination and Temozolomide for Recurrent Glioblastoma Multiforme
Glioblastoma Multiforme (GBM)
Malaghan Institute of Medical Research17 enrolled1 locationACTRN12611000029998