Human Papillomavirus Clinical Trials

45 recruitingLast updated: July 26, 2026

There are 45 actively recruiting human papillomavirus clinical trials across 21 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 4. Top locations include Houston, Texas, United States, Birmingham, Alabama, United States, Atlanta, Georgia, United States. Updated daily from ClinicalTrials.gov.


Human Papillomavirus Trials at a Glance

45 actively recruiting trials for human papillomavirus are listed on ClinicalTrialsFinder across 6 cities in 21 countries. The largest study group is Not Applicable with 19 trials, with the heaviest enrollment activity in Houston, Birmingham, and Atlanta. Lead sponsors running human papillomavirus studies include National Cancer Institute (NCI), Mayo Clinic, and M.D. Anderson Cancer Center.

Browse human papillomavirus trials by phase

Treatments under study

About Human Papillomavirus Clinical Trials

Looking for clinical trials for Human Papillomavirus? There are currently 7 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Human Papillomavirus trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Human Papillomavirus clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 45 trials

Recruiting
Not Applicable

Evaluation of the Q-Pad hrHPV Test System for Identifying Precancer

Cervical Cancer ScreeningHPV InfectionHPV+8 more
Qurasense450 enrolled3 locationsNCT07281599
Recruiting
Phase 2

Treatment of Recurrent Genital Warts by Combination of CO2 Laser and Geniwa Gel

HPV (Human Papillomavirus)-AssociatedGenital warts
KTH Biopharma70 enrolled1 locationNCT07698886
Recruiting
Phase 1

Decitabine in Combination With Standard of Care Therapy for the Treatment of Surgically Resectable HPV-Negative Head and Neck Cancer

Resectable Head and Neck Squamous Cell CarcinomaHuman Papillomavirus-Negative Neck Squamous Cell CarcinomaResectable Human Papillomavirus-Independent Head and Neck Mucosal Squamous Cell Carcinoma+1 more
Mayo Clinic32 enrolled1 locationNCT06997094
Recruiting
Phase 1Phase 2

A Phase I/IIa Clinical Trial to Investigate BVAC-E6E7 in Subjects With HPV Positive HNSCC.

Head and Neck Squamous Cell Carcinoma (HNSCC)HPV Positive Oropharyngeal Squamous Cell CarcinomaHPV (Human Papillomavirus)-Associated Carcinoma
Cellid Co., Ltd.37 enrolled2 locationsNCT06797986
Recruiting
Not Applicable

Self-collection for HPV Testing to Improve Cervical Cancer Prevention (SHIP) Trial (LMI-001-A-S04)

Cervical CarcinomaHuman Papillomavirus Infection
National Cancer Institute (NCI)500 enrolled18 locationsNCT07281430
Recruiting

Natural History, Epidemiology and Pathogenesis of Severe HPV-Related Diseases (Neptune)

Human Papillomavirus
National Institute of Allergy and Infectious Diseases (NIAID)850 enrolled1 locationNCT05026138
Recruiting
Phase 1

HPV DNA Vaccine Via Electroporation for HPV16 Positive Cervical Neoplasia

Human Papillomavirus Type 16Cervical Intraepithelial Neoplasia Grade IICervical Intraepithelial Neoplasia, Grade III
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins48 enrolled2 locationsNCT04131413
Recruiting
Not Applicable

Secondary Cervical Cancer Prevention of Vulnerable Women With HPV and HIV Co-infection in India

Cervical CancerHuman Papillomavirus (HPV) InfectionHuman Immunodeficiency Virus (HIV) Infection
University of California, Irvine348 enrolled3 locationsNCT07209917
Recruiting
Phase 1

Testing RG1-VLP Vaccine to Prevent HPV-related Cancers

Human Papillomavirus-Related Carcinoma
National Cancer Institute (NCI)18 enrolled5 locationsNCT05985681
Recruiting
Phase 2

Phase II Trial of Neoadjuvant Chemotherapy (NAC) Alone or in Combination With Immunotherapy Vaccine PRGN-2009 in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal (Head and Neck) Cancer

Squamous Cell Carcinoma of the Head and NeckDrug TherapyOropharynx+2 more
National Cancer Institute (NCI)70 enrolled1 locationNCT06223568
Recruiting

Evaluation of a Novel Point-of-Care Diagnostic Test for Human Papillomavirus (HPV)

Human Papillomavirus
M.D. Anderson Cancer Center600 enrolled1 locationNCT06434337
Recruiting
Phase 2

De-Escalated Adjuvant and Definitive Radiation Therapy Informed by DART 2.0 ctHPV-DNA

Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8+4 more
Mayo Clinic455 enrolled3 locationsNCT05541016
Recruiting
Not Applicable

Investigating Facilitator-driven, Multi-level Implementation Strategies in Federally Qualified Health Centers to Improve Provider Recommendation and HPV Vaccination Rates Among Latino/a Adolescents

Human Papillomavirus Infection
The University of Texas Health Science Center, Houston225 enrolled1 locationNCT06598475
Recruiting
Phase 2

Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN)

Head and Neck CancerLaryngeal CancerOral Cavity Cancer+6 more
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins75 enrolled1 locationNCT07209189
Recruiting
Not Applicable

Digital Telecytology for Triage of HPV-Positive Women in Cameroon

Human Papillomavirus InfectionCervical Cancer Screening MethodsCervical Intraepithelial Neoplasia Grade 2 (CIN2)
University Hospital, Geneva1,800 enrolled2 locationsNCT07550010
Recruiting
Not Applicable

Self-collection for HPV Testing to Improve Cervical Cancer Prevention (SHIP) Trial (LMI-001-A-S01)

Cervical CarcinomaHuman Papillomavirus Infection
National Cancer Institute (NCI)750 enrolled15 locationsNCT06498661
Recruiting
Not Applicable

The Effect of a Transtheoretical Model-Based Educational Intervention on First-Year Nursing Students' HPV Knowledge, Health Beliefs, and Vaccination Behavior Intentions

Health Knowledge, Attitudes, PracticeHealth BehaviorHuman Papillomavirus (HPV)+2 more
Cukurova University88 enrolled2 locationsNCT07248904
Recruiting
Not Applicable

Self-sampling for Non-attenders to Cervical Cancer Screening

Cervical CancerCervical DysplasiaHuman Papillomavirus Infection
The Institute of Molecular and Translational Medicine, Czech Republic15,000 enrolled1 locationNCT04226313
Recruiting

The Role of Circulating Tumour DNA in Head and Neck Cancer

Oropharyngeal Squamous Cell CarcinomaHuman Papillomavirus (HPV)
University of Edinburgh250 enrolled5 locationsNCT05539638
Recruiting
Not Applicable

Point of Care - Triage and Treatment for Cervical Pre-cancer

Cervical Intraepithelial NeoplasiaHuman Papillomavirus InfectionCervical Precancer
Basic Health International, Inc.5,000 enrolled1 locationNCT07461818