Phase 1 Hypertension Clinical Trials
51 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 51 trials
Recruiting
Phase 1
A Study of LY3971297 in Healthy Participants
ObesityHypertensionHealthy
Eli Lilly and Company225 enrolled7 locationsNCT06148272
Recruiting
Phase 1
Study of Intravenous ZMA001 in Healthy Subjects
Pulmonary Arterial Hypertension PAH
National Heart, Lung, and Blood Institute (NHLBI)96 enrolled1 locationNCT05967299
Recruiting
Phase 1
Metabolic Effects of Angiotensin-(1-7)
ObesityInsulin ResistanceHypertension+1 more
Vanderbilt University26 enrolled1 locationNCT02646475
Recruiting
Phase 1Phase 2
A Phase Ⅰb/Ⅱa Clinical Study of IMC-003 Injection for the Treatment of Pulmonary Arterial Hypertension Receiving Background Therapy.
Pulmonary Arterial Hypertension PAH
ImmuneCare Biopharmaceuticals (Shanghai) Co., Ltd.120 enrolled32 locationsNCT07593027
Recruiting
Phase 1
Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease
AsthmaCOPDCystic Fibrosis+4 more
Mario Castro, MD, MPH260 enrolled1 locationNCT04624490
Recruiting
Phase 1Phase 2
A Study to Learn About the Treatment LTP001 in Healthy Participants (Part A) and in Participants With PAH (Part B)
Healthy Volunteers, Pulmonary Arterial Hypertension
Novartis Pharmaceuticals232 enrolled85 locationsNCT06649110
Recruiting
Phase 1
A Study Evaluating the Safety and Tolerability of Artesunate in Patients With Pulmonary Arterial Hypertension
Pulmonary Arterial Hypertension PAH
Joseph C. Wu15 enrolled1 locationNCT06872112
Recruiting
Phase 1Phase 2
Feasibility of Semaglutide in Advanced Lung Disease
ObesityChronic Obstructive Pulmonary DiseaseInterstitial Lung Disease+2 more
University of Pennsylvania8 enrolled1 locationNCT05746039
Not Yet Recruiting
Phase 1
Phase 1, Open-label, Proof-of Concept Study to Evaluate the Effect of SDS089 Nasal Spray on the Pulmonary Vascular Resistance (PVR) from right hand catheterisation of newly diagnosed and untreated Pulmonary Arterial Hypertension (PAH) patients.
Pulmonary Arterial Hypertension
LTR Pharma Ltd6 enrolled1 locationACTRN12626000434392
Recruiting
Phase 1
Chronic Hypertension and Pregnancy 2 (CHAP2) Pilot Project
Hypertension in Pregnancy
University of Alabama at Birmingham74 enrolled1 locationNCT05989581
Recruiting
Phase 1
Safety and Efficacy of SC101 Via Perirenal Fat Injection for Resistant Hypertension in Patients With Moderate to Severe Chronic Kidney Disease
Resistant Arterial HypertensionChronic Kidney Disease (Stage 3-4)
The First Affiliated Hospital with Nanjing Medical University3 enrolled1 locationNCT07483372
Recruiting
Phase 1
Bridge to Lung Transplant With Trans-septal Extra-corporeal Membrane Oxygenation (ECMO) for Right Heart Failure From Pulmonary Hypertension
Lung TransplantPulmonary Hypertension
Mayo Clinic4 enrolled1 locationNCT06770023
Recruiting
Phase 1Phase 2
EUS Guided Portal-systemic Pressure Gradient Measurement
CirrhosisPortal Hypertension
Chinese University of Hong Kong30 enrolled1 locationNCT04633356
Recruiting
Phase 1Phase 2
AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension
Open Angle GlaucomaOcular Hypertension
AbbVie96 enrolled49 locationsNCT04499248
Recruiting
Phase 1
A Study on the Efficacy and Safety of Empagliflozin in the Treatment of Pulmonary Arterial Hypertension
Pulmonary Arterial Hypertension
China National Center for Cardiovascular Diseases72 enrolled1 locationNCT06554301
Recruiting
Phase 1
Preliminary Human Trials of F230 Tablets
Pulmonary Hypertension
Beijing Continent Pharmaceutical Co, Ltd.136 enrolled1 locationNCT06899815
Recruiting
Phase 1
Study of KK3910 in Healthy Volunteers and Patients With Essential Hypertension
Healthy Volunteers Essential Hypertension
Kyowa Kirin Co., Ltd.160 enrolled3 locationsNCT06823947
Recruiting
Phase 1Phase 2
Umbilical Cord Blood CD19-BCMA CART Cell Therapy for SLE-LN, SSc, andpSS PAH.
Refractory Lupus NephritisSystemic SclerosisPrimary Sjogren's Syndrome Combined With Pulmonary Hypertension
Beijing GoBroad Hospital45 enrolled1 locationNCT06947473
Recruiting
Phase 1Phase 2
CD19-BCMA CART Cell Therapy for Refractory SLE-LN, SSc, and pSS-PAH
Refractory Lupus NephritisSystemic SclerosisPrimary Sjogren's Syndrome Combined With Pulmonary Hypertension
Beijing GoBroad Hospital45 enrolled1 locationNCT06947460
Recruiting
Phase 1Phase 2
Sympathetic Mechanisms in Obesity-Crossover Design
ObesityHypertension
Vanderbilt University Medical Center12 enrolled1 locationNCT05312892