Phase 1 Intestinal Cancer Clinical Trials
23 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 23 trials
Recruiting
Phase 1Phase 2
Study of Patritumab Deruxtecan in Participants With Gastrointestinal Cancers (MK-1022-011) (HERTHENA-PanTumor02)
Gastrointestinal Cancer
Merck Sharp & Dohme LLC180 enrolled62 locationsNCT06596694
Recruiting
Phase 1Phase 2
SL-28 for Advanced Solid Tumours
Breast CancerLiver CancerColorectal, Cancer+15 more
Second Life Therapeutics60 enrolled1 locationNCT07341737
Recruiting
Phase 1
Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies
Colorectal, CancerOvarian CancerPeritoneal Carcinomatosis+4 more
National Cancer Institute (NCI)60 enrolled1 locationNCT04847063
Recruiting
Phase 1Phase 2
Phase 1/2 Study of BHB810 in Advanced Gastric and GEJ Adenocarcinoma
Pancreatic CancerGastric CancerGastric (Stomach) Cancer+11 more
BigHat Biosciences, Inc.164 enrolled1 locationNCT07529808
Recruiting
Phase 1Phase 2
Evaluation of the Preliminary Efficacy and Safety of DR30206 in Combination With Standard Therapy in Patients With Gastrointestinal Cancer
Gastrointestinal Cancer
Zhejiang Doer Biologics Co., Ltd.186 enrolled1 locationNCT07056777
Recruiting
Phase 1Phase 2
Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients
Pancreatic CancerGastric CancerColon Cancer+2 more
National Cancer Institute (NCI)110 enrolled1 locationNCT03190941
Recruiting
Phase 1Phase 2
A Study of DB-1324 in Advanced/Metastatic Gastrointestinal Tumors
Gastrointestinal Cancer
DualityBio Inc.127 enrolled9 locationsNCT07263594
Recruiting
Phase 1Phase 2
Dose-defining Study of Tirapazamine Combined With Embolization in Liver Cancer
Hepatocellular CarcinomaNeuroendocrine TumorsGastrointestinal Cancer Metastatic
Teclison Ltd.25 enrolled2 locationsNCT02174549
Recruiting
Phase 1
Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple Myeloma
Breast CancerOvarian CancerProstate Cancer+6 more
Nammi Therapeutics Inc100 enrolled10 locationsNCT06582017
Recruiting
Phase 1Phase 2
Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
Colorectal, CancerPancreatic Ductal AdenocarcinomaMetastatic Pancreatic Ductal Adenocarcinoma+3 more
Revolution Medicines, Inc.1,130 enrolled32 locationsNCT06445062
Recruiting
Phase 1
A Study to Test Different Doses of BI 765049 Alone and in Combination With Ezabenlimab in Asian People With Advanced Cancer (Solid Tumours) Positive for B7-H6
Pancreatic CancerLung CancerGastrointestinal Cancer
Boehringer Ingelheim97 enrolled7 locationsNCT06091930
Recruiting
Phase 1Phase 2
Remote Resistance Exercise Powering Survivors - Gastrointestinal Oncology
Gastrointestinal Cancer
H. Lee Moffitt Cancer Center and Research Institute100 enrolled1 locationNCT05664178
Recruiting
Phase 1
Autologous T-cells Genetically Engineered to Express Receptors Reactive Against KRAS Mutations in Conjunction With a Vaccine Directed Against These Antigens in Participants With Metastatic Cancer
Breast CancerColorectal, CancerOvarian Cancer+4 more
National Cancer Institute (NCI)210 enrolled1 locationNCT06253520
Recruiting
Phase 1
Safety, Tolerance and Preliminary Efficacy of XH001 Injection Combined With Neoantigen Vaccine-induced Tumor-specific T-cell Injection in Advanced Gastrointestinal Cancer
Gastrointestinal Cancer
Beijing GoBroad Hospital18 enrolled1 locationNCT07329894
Recruiting
Phase 1
Sacituzumab Govitecan in Combination With Capecitabine for Advanced Gastrointestinal Cancers After Progression on Standard Therapy
Gastrointestinal Cancer
Henry Ford Health System20 enrolled1 locationNCT06065371
Recruiting
Phase 1
A Study of GC203 TIL in Advanced Malignant Solid Tumors
Breast CancerLung CancerSolid Tumor+2 more
Shanghai Juncell Therapeutics18 enrolled1 locationNCT06375187
Recruiting
Phase 1
Neratinib and Fam-Trastuzumab Deruxtecan in Advanced Gastro-esophageal Cancer Patients
Gastric CancerGastrointestinal CancerHER2 Gene Mutation
Fox Chase Cancer Center18 enrolled3 locationsNCT05274048
Recruiting
Phase 1Phase 2
Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 Patients
Pancreatic CancerGastric CancerColon Cancer+2 more
National Cancer Institute (NCI)70 enrolled1 locationNCT03745326
Recruiting
Phase 1Phase 2
Optimizing and Personalising Azacitidine Combination Therapy for Treating Solid Tumours QPOP and CURATE.AI
Breast CancerSolid TumorGastrointestinal Cancer
National University Hospital, Singapore10 enrolled1 locationNCT05381038
Recruiting
Phase 1
Treatment of Cabotamig (ARB202) in Advanced Gastrointestinal Cancer Patients
Liver CancerPancreatic CancerGastric Cancer+6 more
Arbele Pty Ltd68 enrolled3 locationsNCT05411133