Phase 1 Knee Clinical Trials
29 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 29 trials
Recruiting
Phase 1Phase 2
COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty
Total Knee AnthroplastyOsteoarthritis PrimaryBilateral Knee Osteoarthritis+1 more
Unity Health Toronto60 enrolled1 locationNCT06809998
Recruiting
Phase 1
Methylene Blue in Total Knee Arthroplasty (TKA)
Total Knee ArthroplastyProsthetic joint infectionIrrigation
University of Miami20 enrolled1 locationNCT07324954
Recruiting
Phase 1
Study to Assess the Safety and Pharmacokinetics of AVD275 Injection in Patients With Osteoarthritis of the Knee
Osteoarthritis of the knee
Avidence Therapeutics15 enrolled1 locationNCT07338266
Recruiting
Phase 1
A Phase Ib Study to Evaluate the Efficacy and Safety of HRS-2129 in Patients With Knee Osteoarthritis
Moderate Pain in Knee OsteoarthritisSevere Pain in Knee Osteoarthritis
Shandong Suncadia Medicine Co., Ltd.200 enrolled1 locationNCT07351968
Recruiting
Phase 1Phase 2
Recombinant Human Growth Hormone (rHGH) for Knee Osteoarthritis (KORR)
Knee Osteoarthritis (Knee OA)Knee osteoarthritis (OA)
Dr. David Wasserstein34 enrolled1 locationNCT07036003
Recruiting
Phase 1Phase 2
The Role of Vitamin K on Knee Osteoarthritis Outcomes
Osteo Arthritis Knee
Boston University55 enrolled1 locationNCT06385275
Recruiting
Phase 1
A Clinical Study to Evaluate the Safety, Tolerability and Efficacy of BBM-A101 in the Treatment of Knee Osteoarthritis.
Knee Osteoarthritis
Belief BioMed (Beijing) Co., Ltd81 enrolled2 locationsNCT07198555
Recruiting
Phase 1
FiH Safety and Feasibility Study Assessing Intra-articular Administration of aeGF in Patients With Knee Osteoarthritis
Osteoarthritis, Knee
Scarcell Therapeutics S.A.S.15 enrolled1 locationNCT06690710
Recruiting
Phase 1Phase 2
CBD for Knee Osteoarthritis
Osteoarthritis, Knee
University of Florida30 enrolled1 locationNCT06414473
Not Yet Recruiting
Phase 1
Study on RUNX1 mRNA for Safety in Osteoarthritis Patients scheduled for Knee Replacement Surgery
knee replacement
PrimRNA AU Pty Ltd12 enrolled1 locationACTRN12625000800426
Recruiting
Phase 1
Oral Steroid Taper After Total Knee Arthroplasty
Osteoarthritis, Knee
Columbia University130 enrolled1 locationNCT07070882
Recruiting
Phase 1Phase 2
Intraosseous (IO) Cefazolin and Vancomycin in Primary Total Knee Arthroplasty (TKA)
Total Knee Arthroplasty
The Methodist Hospital Research Institute40 enrolled1 locationNCT06640491
Recruiting
Phase 1
Use of Extracellular Vesicles (EV) for Knee Osteoarthrosis
Knee Osteoarthrosis
University of Jordan50 enrolled1 locationNCT06937528
Recruiting
Phase 1
Optimal Anesthetic for Corticosteroid Injections for Knee Osteoarthritis
Knee Osteoarthritis
Foundation for Orthopaedic Research and Education75 enrolled1 locationNCT05906433
Recruiting
Phase 1
Phase I Clinical Trial of UC-MSCs in the Treatment of Knee Osteoarthritis
Knee Osteoarthritis
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology18 enrolled1 locationNCT06463847
Recruiting
Phase 1Phase 2
Allogenic Mesenchymal Stem Cell Intraarticular Injection for Knee Osteoarthritis Therapy
Knee Osteoarthritis
Aarhus University Hospital80 enrolled1 locationNCT05933434
Recruiting
Phase 1
Six-month Performance of Meniscal Wall Infiltration Under Ultrasound to Treat Stable Degenerative Meniscal Injuries.
Osteoarthritis, Knee
Centre Hospitalier Universitaire de Nīmes70 enrolled1 locationNCT05235854
Recruiting
Phase 1
Bioequivalence Assessment of Topical Smartech 2% Diclofenac Sodium Solution Compared to a Reference Product When Applied to the Knees of Healthy Male and Female Participants
Osteoarthritis of the knee
Smartech Topical AU Pty Ltd90 enrolled1 locationACTRN12624000341527
Recruiting
Phase 1Phase 2
Mitigation of Arthrofibrosis After Total Knee Arthroplasty Using Losartan
Knee Arthroplasty, Total
Steadman Philippon Research Institute120 enrolled1 locationNCT06108063
Completed
Phase 1
A Phase I, Open-Label Study to Evaluate the Safety and Pharmacokinetics of APC201 in Healthy Volunteers
AnaesthesiologyPain associated with osteoarthritis of the knee
Andros Pharmaceuticals Pty Ltd10 enrolled1 locationACTRN12623000261617