Liver Diseases Clinical Trials

45 recruitingLast updated: June 18, 2026

There are 45 actively recruiting liver diseases clinical trials across 31 countries. Studies span Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3. Top locations include Philadelphia, Pennsylvania, United States, Chicago, Illinois, United States, Los Angeles, California, United States. Updated daily from ClinicalTrials.gov.


Liver Diseases Trials at a Glance

45 actively recruiting trials for liver diseases are listed on ClinicalTrialsFinder across 6 cities in 31 countries. The largest study group is Not Applicable with 21 trials, with the heaviest enrollment activity in Philadelphia, Chicago, and Los Angeles. Lead sponsors running liver diseases studies include Assistance Publique - Hôpitaux de Paris, Arbor Research Collaborative for Health, and Anhui Provincial Hospital.

Browse liver diseases trials by phase

Treatments under study

About Liver Diseases Clinical Trials

Looking for clinical trials for Liver Diseases? There are currently 39 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Liver Diseases trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Liver Diseases clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 45 trials

Recruiting
Phase 1

A Study to Assess the Safety and Pharmacokinetics of INCB123667 When Administered Orally to Adult Participants With Moderate or Severe Hepatic Impairment

Liver DiseasesHepatic Insufficiency
Incyte Corporation16 enrolled4 locationsNCT07559474
Recruiting

Primary Sclerosing Cholangitis in Children

Liver DiseasesPrimary Sclerosing CholangitisCholangitis, Sclerosing
Arbor Research Collaborative for Health1,000 enrolled12 locationsNCT04181138
Recruiting
Not Applicable

Comparison of Inflammatory Profiles and Regenerative Potential in Alcoholic Liver Disease

Liver DiseasesAcute on Chronic Hepatic Failure
University Hospital, Lille450 enrolled1 locationNCT03773887
Recruiting

China Metastatic Liver Cancer Clinical Registry Cohort Database

Liver CancerLiver MetastasesNeoplasms+3 more
Anhui Provincial Hospital2,000 enrolled3 locationsNCT07602504
Recruiting
Phase 4

The Treatment of Liver Injury After Liver Resection With Polyene Phosphatidylcholine

Hepatocellular Carcinoma (HCC)Liver Diseases
Anhui Provincial Hospital96 enrolled1 locationNCT07150624
Recruiting

Impact of Iron Overload on the Incidence of Liver Complications in Long-Term Survivors (≥10 Years) of Allogeneic Hematopoietic Stem-Cell Transplantation.

Liver DiseasesHematopoietic Stem Cell Transplantation (HSCT)Iron Overload+1 more
Assistance Publique - Hôpitaux de Paris500 enrolled1 locationNCT07028112
Recruiting
Not Applicable

Assessing Declined Liver Grafts With Normothermic Machine Perfusion to Reduce Transplant Waiting Time

SurgeryLiver DiseasesLiver Transplantation
Charite University, Berlin, Germany186 enrolled10 locationsNCT06874296
Recruiting

DILIN - Prospective Study

Liver Diseases
Duke University4,000 enrolled6 locationsNCT00345930
Recruiting
Phase 2

A Study to Investigate the Safety and Efficacy of GSK4532990 Compared With Placebo in Adult Participants Aged 18 to 70 Years With Alcohol-related Liver Disease

Liver Diseases, Alcoholic
GlaxoSmithKline393 enrolled131 locationsNCT06613698
Recruiting
Not Applicable

Development of a FibroScan Liver Examination Using a Single Probe

Liver Diseases
Echosens309 enrolled4 locationsNCT07400289
Recruiting
Not Applicable

Veteran-Centered Care for Advanced Liver Disease (Vet-CALD)

Liver Diseases
VA Office of Research and Development450 enrolled8 locationsNCT06068491
Recruiting
Not Applicable

Enhancing Alcohol Treatment Engagement in Associated Liver Disease (ALD) Patients

Liver DiseasesAlcohol-related Liver Disease
Henry Ford Health System268 enrolled1 locationNCT06269510
Recruiting
Phase 1Phase 2

RTX001 Autologous Engineered Macrophages for Liver Cirrhosis

Liver DiseasesCirrhosis, LiverDecompensated Liver Cirrhosis+5 more
Resolution Therapeutics Limited30 enrolled14 locationsNCT06823713
Recruiting

MAsS Scan as a Predictor of Morbidity and Mortality in Patients With Liver Disease

Liver Diseases
University of Chicago1,200 enrolled1 locationNCT05264051
Recruiting

Prediction of Decompensation and HCC Development in Advanced Chronic Liver Disease

Hepatocellular CarcinomaHepatocarcinomaLiver Diseases+1 more
University Hospital Muenster600 enrolled1 locationNCT06523608
Recruiting
Not Applicable

Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial

Insulin Sensitivity/ResistanceObesityInsulin Resistance+16 more
Pichamol Jirapinyo, MD, MPH132 enrolled2 locationsNCT06138821
Recruiting
Not Applicable

Alcohol Misuse Treatment to Patients Newly Diagnosed With Alcohol-related Liver Disease: a Randomized Controlled Trial

AlcoholismAlcohol Use DisorderTreatment Adherence+2 more
Zealand University Hospital221 enrolled1 locationNCT06493773
Recruiting
Phase 1

The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) Trial

Liver DiseasesCirrhosis, LiverLiver Failure
University of Chicago24 enrolled1 locationNCT06871111
Recruiting
Not Applicable

A Trial of Post-Discharge Transitional Care for Patients With Chronic Liver Disease

Liver Diseases
Indiana University1,000 enrolled4 locationsNCT05733832
Recruiting

Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs

Liver Transplant; ComplicationsLiver CirrhosisLiver Diseases+1 more
European Foundation for Study of Chronic Liver Failure3,000 enrolled106 locationsNCT04613921