Liver Metastasis Clinical Trials

39 recruitingLast updated: June 18, 2026

There are 39 actively recruiting liver metastasis clinical trials across 13 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3, Early Phase 1. Top locations include London, Ontario, Canada, Oslo, Norway, Amsterdam, North Holland, Netherlands. Updated daily from ClinicalTrials.gov.


Liver Metastasis Trials at a Glance

39 actively recruiting trials for liver metastasis are listed on ClinicalTrialsFinder across 6 cities in 13 countries. The largest study group is Not Applicable with 13 trials, with the heaviest enrollment activity in London, Oslo, and Amsterdam. Lead sponsors running liver metastasis studies include Amsterdam UMC, location VUmc, Francesco De Cobelli, and Leiden University Medical Center.

Browse liver metastasis trials by phase

Treatments under study

About Liver Metastasis Clinical Trials

Looking for clinical trials for Liver Metastasis? There are currently 7 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Liver Metastasis trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Liver Metastasis clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 39 trials

Recruiting
Not Applicable

Preoperative Ketogenic Diet for Reduction of Hepatic Steatosis

Liver Metastasis Colon CancerLiver SteatosesNAFLD
Anton Skaro124 enrolled1 locationNCT05884723
Recruiting
Early Phase 1

Botensilimab, Balstilimab, and SBRT in Colorectal Cancer

Non-MSI-H or pMMR Colorectal Cancer With Liver Metastasis
Massachusetts General Hospital15 enrolled1 locationNCT07128355
Recruiting

GUIDE.MRD-01-CRC: Clinical Validation and Benchmarking of Top Performing ctDNA Diagnostics - Colorectal Cancer

Liver Metastasis Colon CancerColorectal Cancer Stage III
Claus Lindbjerg Andersen590 enrolled15 locationsNCT06111105
Recruiting
Phase 2

Fruquintinib Combined With Sintilimab ± Radiotherapy for Third-line Treatment of Colorectal Cancer With Liver Metastases

Colorectal, CancerRadiotherapyTargeted Therapy+2 more
Shandong Cancer Hospital and Institute62 enrolled1 locationNCT06356584
Recruiting
Not Applicable

Scout Dose of Resin Microspheres

Hepatocellular Carcinoma (HCC)Intrahepatic Cholangiocarcinoma (Icc)Liver Metastasis+1 more
Seoul National University Hospital30 enrolled1 locationNCT07476651
Recruiting
Not Applicable

Electrochemotherapy (ECT) in Patients With Primary Visceral Tumors and/or Secondary Visceral Localizations, of Any Histotype

Liver CancerMelanomaMerkel Cell Carcinoma+9 more
Istituto Oncologico Veneto IRCCS24 enrolled1 locationNCT06753136
Recruiting
Phase 1

LDRT Combined With Immunochemotherapy for Colorectal Cancer With Liver Metastasis

Colorectal, CancerLiver MetastasisLDRT
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University9 enrolled2 locationsNCT06848465
Recruiting

Advanced Therapies for Liver Metastases

Pancreatic Ductal Adenocarcinoma (PDAC)Colorectal Cancer (CRC)Liver Metastasis+1 more
IRCCS San Raffaele625 enrolled1 locationNCT04622423
Recruiting

Biopsy After Radioembolization to Identify Changes in Tumor Cells From the Radiation

Colorectal, CancerColon CancerLiver Metastasis Colon Cancer+3 more
Memorial Sloan Kettering Cancer Center80 enrolled1 locationNCT04668872
Recruiting

Prospective Validation of an AI Model for Predicting Liver Metastasis in Colorectal Cancer

Colorectal Cancer Liver Metastasis
Tongji Hospital160 enrolled1 locationNCT07392567
Recruiting

The Use of Artificial Intelligence for the Prediction of Recurrence After Resection of Colorectal Liver Metastases

Colorectal Liver Metastasis (CRLM)Liver ResectionHepatectomy+1 more
Francesco De Cobelli1,000 enrolled1 locationNCT07385521
Recruiting

Selective Internal Radiation Therapy With 90Y Resin Micropheres for Refractory Colorectal Cancer Liver Metastases

Liver Metastasis Colon Cancer
Aarhus University Hospital30 enrolled1 locationNCT04491929
Recruiting

Feasibility of Circulating Tumour DNA (ctDNA) Analysis Using Automated Capillary Blood Sampling

Colorectal Cancer (Diagnosis)Colorectal Liver Metastasis (CRLM)Circulating Tumor DNA (ctDNA)
Erasmus Medical Center35 enrolled1 locationNCT07310537
Recruiting
Phase 2

Phase II Trial of Albumin-Bound Paclitaxel Combined With Nedaplatin (TP) Via Hepatic Arterial Infusion for Advanced Breast Cancer Patients With Liver Metastases After Failure of Standard Therapy

Hepatic Artery InfusionLiver Metastasis of Breast Cancer
Zhejiang Cancer Hospital30 enrolled1 locationNCT07284836
Recruiting

Comparison of the Resection Site Order in Simultaneous Approach of Colorectal Liver Metastasis

Colorectal Liver Metastasis
Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria500 enrolled1 locationNCT07272928
Recruiting
Not Applicable

LDLT in Non Resectable Colo-rectal Cancer Liver Metastasis

Liver Metastasis Colon CancerColon Adenocarcinoma
Azienda Ospedaliero-Universitaria di Modena25 enrolled1 locationNCT05186116
Recruiting

FDG PET-CT in Advanced Breast Cancer

Histologically Confirmed Metastatic or Locally Advanced Breast Cancer With no Radical Topical Treatment AvailableIf There is Liver Metastasis, Which the Researcher Believes Will be Difficult to Evaluate the Response Accurately With Bone Metastasis or CT
Samsung Medical Center100 enrolled1 locationNCT07173868
Recruiting

Prospective Cohort Study on Thermal Ablation of Malignant Liver Tumors

Liver CancerHepatocellular CarcinomaLiver Metastases+1 more
Leiden University Medical Center1,500 enrolled1 locationNCT06179602
Recruiting

Multi-Reader Multi-Case Trial Evaluating Computer-Aided Tool for Prognostic Prediction of Colorectal Liver Metastases

Colorectal Liver Metastasis (CRLM)
Cancer Institute and Hospital, Chinese Academy of Medical Sciences166 enrolled1 locationNCT07027605
Recruiting
Not Applicable

Simultaneous vs. Staged Resection of Colorectal Cancer With Synchronous Liver Metastases

Colorectal, CancerLiver MetastasesLiver Metastasis Colon Cancer+1 more
Oslo University Hospital80 enrolled1 locationNCT06200831