Phase 2 Malaria Clinical Trials
17 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–17 of 17 trials
Recruiting
Phase 2
Safety and Efficacy of Imatinib in Combination With Artemether-Lumefantrine for Uncomplicated Malaria
Malaria (Plasmodium Falciparum)
Victoria Biomedical Research Institute1,116 enrolled1 locationNCT07559370
Recruiting
Phase 2
Dose Finding Trial of R21/Matrix-M in School Children
Malaria (Plasmodium Falciparum)
University of Oxford40 enrolled1 locationNCT07074665
Recruiting
Phase 2
L9LS in Women of Childbearing Potential in Mali
Malaria
National Institute of Allergy and Infectious Diseases (NIAID)290 enrolled3 locationsNCT07060508
Recruiting
Phase 2
Pfs230D1 + R21 in Matrix-M1 in African School Children and Adults
Prevention of Malaria Transmission and Clinical Malaria
Serum Institute of India Pvt. Ltd.1,200 enrolled1 locationNCT07147400
Recruiting
Phase 2
A Study to Assess the Safety and Immunogenicity of a Vaccine Against Malaria in Healthy Children Aged 5-60 Months
Malaria
GlaxoSmithKline238 enrolled2 locationsNCT07036159
Recruiting
Phase 2
Infant Malaria Vaccine Schedule Optimization
Malaria Vaccines
PATH1,200 enrolled2 locationsNCT06879327
Recruiting
Phase 1Phase 2
DON in Pediatric Cerebral Malaria
Malaria, Cerebral
Douglas Postels, MD, MS152 enrolled2 locationsNCT05478720
Recruiting
Phase 1Phase 2
A Study to Test Experimental Blood Stage Malaria Vaccine in Burkina Faso.
Malaria,Falciparum
University of Oxford480 enrolled1 locationNCT05790889
Recruiting
Phase 2
Evaluating the safety, tolerability and anti-parasitic immunity boosting activity of ruxolitinib when co-administered with artemether-lumefantrine in adults with Plasmodium falciparum Induced Blood Stage Malaria
Malaria
QIMR Berghofer Medical Research Institute26 enrolled1 locationACTRN12621000866808
Completed
Phase 2
Defining the effectiveness of Piperaquine in early Plasmodium falciparum malaria infection in healthy volunteers.
Malaria
Queensland Institute of Medical Research24 enrolled1 locationACTRN12613000565741
Completed
Phase 2
An experimental study to characterize the effectiveness of OZ439 against early Plasmodium falciparum blood stage infection in healthy volunteers.
Malaria
Queensland Institute of Medical Research24 enrolled1 locationACTRN12612000814875
Recruiting
Phase 2
A randomised phase 2a trial of safety, efficacy, pharmacokinetics and pharmacodynamics of L-Arginine in severe falciparum malaria
Severe falciparum malaria
Menzies School of Health Research57 enrolled1 locationACTRN12612000571875
Completed
Phase 2
An experimental study to characterize the effectiveness of Lariam (Registered Trademark) (Mefloquine) against early malaria blood stage infection in healthy volunteers.
Malaria
The Queensland Institute of Medical Research24 enrolled1 locationACTRN12612000323820
Completed
Phase 2
Immune response in a human malaria challenge system.
Malaria
Queensland Institute of Medical Research16 enrolled1 locationACTRN12611001203943
Recruiting
Phase 2
A pilot study comparing the efficacy of artesunate alone and artesunate plus azithromycin for the treatment of Plasmodium falciparum malaria in central Vietnam
Malaria infection
Australian Army Malaria Institute60 enrolled1 locationACTRN12610000546055
Not Yet Recruiting
Phase 2
Multiple-dose pharmacokinetics and ex vivo pharmacodynamics of the fixed-dosed artemisinin based combination therapies (ACTs) of the antimalarial drugs Artequick (artemisinin-piperaquine) and Coarsucam (artesunate-amodiaquine) in healthy male Vietnamese volunteers
Characterization of the pharmacokinetics (absorption, metabolism, distribution and elimination) of the components of the antimalarial drugs Artequick and Coarsucam in healthy Vietnamese volunteers will provide important data for dose optimization and measurement of interindividual variability in plasma drug concentrations.
Australian Department of Defence44 enrolled1 locationACTRN12609000846224
Completed
Phase 2Phase 3
Evaluation of Tafenoquine for the Post-Exposure Prophylaxis of Vivax Malaria (Southwest Pacific Type) in Non-Immune Australian Soldiers
Malaria
GlaxoSmithKline600 enrolled1 locationACTRN12607000588493