Phase 3 Malaria Clinical Trials
18 recruitingPhase 3
What is a Phase 3 trial?
Phase 3 trials compare the new treatment against the current standard of care in large groups, often hundreds to thousands of participants. Successful Phase 3 results are typically required for regulatory approval.
Showing 1–18 of 18 trials
Recruiting
Phase 3
Safety of Antimalarials in the FIRst trimEster
Malaria, PregnancyMalaria, AntepartumMalaria (Uncomplicated)
Liverpool School of Tropical Medicine1,510 enrolled3 locationsNCT06962319
Recruiting
Phase 3
FocaL Mass Drug Administration for Vivax Malaria Elimination
Plasmodium Vivax MalariaMalaria
University of California, San Francisco7,530 enrolled1 locationNCT05690841
Recruiting
Phase 3
An Interventional Study to Compare the Efficacy and Safety of Tafenoquine (TQ) and Primaquine (PQ) When Either Are Taken Together With Chloroquine (CQ) for the Treatment of P. Vivax Malaria in Indian Participants Aged 2 Years and Older
Malaria, Vivax
GlaxoSmithKline300 enrolled4 locationsNCT06666491
Recruiting
Phase 3
Monoclonal Antibodies in Children With Severe Anaemia or Severe Malaria to Prevent Malaria After Hospital Discharge
MalariaSevere MalariaSevere Anaemia+1 more
Liverpool School of Tropical Medicine398 enrolled2 locationsNCT07082205
Recruiting
Phase 3
Seasonal R21 Mass Vaccination for Malaria Elimination
Malaria
London School of Hygiene and Tropical Medicine16,200 enrolled2 locationsNCT06578572
Active
Phase 3
Benefits and safety of IRon supplementation with MAlaria chemoprevention to children in Malawi (IRMA) - A randomised controlled trial
Impaired child cognitive developmentStuntingMalaria+2 more
College of Medicine, University of Malawi2,168 enrolled1 locationACTRN12620000386932
Completed
Phase 3Phase 4
The 3-Day Malarone Schedule: Acceptability and Tolerability for Malaria Prophylaxis in Adults Travelling to Malaria Endemic Areas.
Malaria
Colleen Lau222 enrolled1 locationACTRN12616000640404
Not Yet Recruiting
Phase 3Phase 4
Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in the Kobeni site (provide of Hodh El Gharbi) and Timbedra (Hodgh Echargui province), Mauritania
Malaria
Ministry of Health120 enrolled2 locationsACTRN12614001107617
Recruiting
Phase 3Phase 4
Efficacy and safety of artemether-lumefantrine (AL) combination therapy for the treatment of uncomplicated Plasmodium falciparum malaria in 4 sites in India Annuppur district, Madhya Pradesh, Jhabua district, Madhya Pradesh, Bastar district, Chhattisgarh and Palamudistrict, Jharkhand
Malaria
Indian Council of Medical Research, Ministry of Health & Family welfare352 enrolled4 locationsACTRN12614000765628
Recruiting
Phase 3Phase 4
Monitoring the therapeutic efficacy of antimalarial medicines across International borders of India.
Malaria
National Insititute of Malaria Research70 enrolled3 locationsACTRN12614000217606
Recruiting
Phase 3Phase 4
Efficacy and safety of artemether-lumefantrine and dihydroartemisinin-piperaquine phosphate for the treatment of uncomplicated Plasmodium falciparum malaria, and chloroquine for Plasmodium vivax in Ta Beik Kyin Township, Mandalay Region and dihydroartemisinin-piperaquine phosphate for the treatment of uncomplicated Plasmodium falciparum malaria in Ta-mu township, Sagaing Region
Malaria
Department of Medical Research (Upper Myanmar)160 enrolled2 locationsACTRN12614000216617
Recruiting
Phase 3
Efficacy of artesunate 7days therapy for the treatment of uncomplicated Plasmodium falciparum malaria in Pa-an (Mon State) in Myanmar.
Malaria
Clinical Research Unit ( Malaria), Defense Services General Hospital50 enrolled1 locationACTRN12614000215628
Recruiting
Phase 3Phase 4
Efficacy and safety of Dihydroartemisinine-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria, and chloroquine for Plasmodium vivax in Homalin (Sagaing Division), Lashio (Shan State) and Bokepyin (Tanintharyi Division).
Malaria
Clinical Research Unit (malaria), Defense Services General Hospital200 enrolled3 locationsACTRN12614000214639
Completed
Phase 3Phase 4
Artesunate-pyronaridine and artemisinin-naphthoquine combination therapies for Papua New Guinean children with uncomplicated malaria infections
Malaria
University of Western Australia637 enrolled3 locationsACTRN12610000913077
Completed
Phase 3
Pilot Study: Comparison of the efficacy of artemisinin plus piperaquine (Artequick), artesunate plus amodiaquine (Coarsucam) and artesunate plus azithromycin for the treatment of Plasmodium falciparum malaria in Vietnam
Malaria infection
Australian Army Malaria Institute180 enrolled1 locationACTRN12609000816257
Completed
Phase 2Phase 3
Evaluation of Tafenoquine for the Post-Exposure Prophylaxis of Vivax Malaria (Southwest Pacific Type) in Non-Immune Australian Soldiers
Malaria
GlaxoSmithKline600 enrolled1 locationACTRN12607000588493
Recruiting
Phase 3Phase 4
A comparison of artemisinin combination treatment in the form of Coartem® (artemether-lumefantrine) with sulfadoxine-pyrimethamine for treatment of uncomplicated malaria in Jhapa District, Nepal
Malaria
RTI International120 enrolled1 locationACTRN12605000551695
Recruiting
Phase 3Phase 4
Evaluation of new drug treatments including artemisinin combination therapy for uncomplicated malaria in children in Papua New Guinea
Malaria
University of Western Australia600 enrolled1 locationACTRN12605000550606