Phase 1 Malaria Clinical Trials
40 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 40 trials
Recruiting
Phase 1
Single Ascending Dose Study to Assess the Safety, Tolerability and Pharmacokinetics of LAI MMV055 Alone and in Combination With MMV371 in Healthy Participants
Malaria,Falciparum
Medicines for Malaria Venture72 enrolled1 locationNCT07011511
Recruiting
Phase 1
Induced Blood-Stage Malaria in Healthy Malaria-Naive Adults to Assess the Safety and Infectivity of Plasmodium Vivax Challenge Agent and Evaluate Transmission in Mosquito Feeding Assays
Malaria
National Institute of Allergy and Infectious Diseases (NIAID)300 enrolled1 locationNCT06607003
Recruiting
Phase 1
Safety, Tolerability and Efficacy Against Controlled Human Malaria Infection of PfSPZ-LARC2 Vaccine in Malaria-naïve Adults
Malaria,Falciparum
Sanaria Inc.58 enrolled1 locationNCT06862453
Recruiting
Phase 1
A Study to Investigate the Safety of GSK4024484 in Healthy Adult Participants
Malaria,Falciparum
GlaxoSmithKline156 enrolled1 locationNCT06171113
Recruiting
Phase 1
A Study to Assess the Experimental Malaria Vaccines R78C and RH5.1 Combined With R21/Matrix-M (a "Multi-stage" Malaria Vaccine)
Malaria,Falciparum
University of Oxford56 enrolled1 locationNCT06958198
Recruiting
Phase 1
A Study of Oral E1018 in Healthy Adult Participants
Healthy ParticipantsMalaria
Eisai Inc.32 enrolled1 locationNCT06854042
Recruiting
Phase 1Phase 2
DON in Pediatric Cerebral Malaria
Malaria, Cerebral
Douglas Postels, MD, MS152 enrolled2 locationsNCT05478720
Recruiting
Phase 1Phase 2
A Study to Test Experimental Blood Stage Malaria Vaccine in Burkina Faso.
Malaria,Falciparum
University of Oxford480 enrolled1 locationNCT05790889
Recruiting
Phase 1
A Study to Determine Safety, Tolerability, and Pharmacokinetics of Different Orally Administered Regimens of the Combination ZY19489-Ferroquine in Adult Asymptomatic Plasmodium Falciparum Carriers
uncomplicated malariaAsymptomatic ConditionFalciparum; Malaria
Zydus Lifesciences Limited36 enrolled1 locationNCT05911828
Recruiting
Phase 1
A pilot study to characterize the safety and infectivity of a Plasmodium knowlesi parasite bank in healthy volunteers
Malaria
QIMR Berghofer Medical Research Institute4 enrolled1 locationACTRN12623001326684
Recruiting
Phase 1
Assessing transmission of Plasmodium falciparum 3D7-MBE008 parasites from healthy participants to mosquitoes
Malaria
QIMR Berghofer Medical Research Institute4 enrolled1 locationACTRN12622001097730
Completed
Phase 1
An Open-label, Single Ascending Dose Study of the Safety, Tolerability, and Pharmacokinetics of LYN-163 in Healthy Volunteers
Malaria
Lyndra®Therapeutics, Inc. (Lyndra)25 enrolled1 locationACTRN12621001218886
Completed
Phase 1
Blood stage antimalarial activity of tafenoquine in healthy subjects infected with Plasmodium falciparum
Malaria
QIMR Berghofer Medical Research Institute60 enrolled1 locationACTRN12620000995976
Completed
Phase 1
Effect of high-fat meal followed by a single-dose oral administration of ZY-19489 in healthy adult volunteers
Malaria
Cadila Healthcare Limited8 enrolled1 locationACTRN12619001466134
Completed
Phase 1
Anti-malarial activity of increasing doses of ZY-19489 in healthy volunteers
Malaria
Cadila Healthcare Limited24 enrolled1 locationACTRN12619001215112
Completed
Phase 1
A pilot study to characterise the in vivo safety and infectivity of a Plasmodium falciparum 3D7-GL master cell bank in healthy subjects
Malaria
QIMR Berghofer Medical Research Institute2 enrolled1 locationACTRN12619001085167
Completed
Phase 1
A pilot study to increase the in vivo safety and infectivity of an in vitro expanded Plasmodium falciparum 3D7-MBE008 master cell bank in healthy subjects
Malaria
QIMR Berghofer Medical Research Institute2 enrolled1 locationACTRN12619001079134
Completed
Phase 1
Safety and immunogenicity of ACT-1239 in healthy volunteers
Malaria
Artificial Cell Technologies, Inc.50 enrolled1 locationACTRN12619001022156
Completed
Phase 1
Safety and tolerability of increasing doses of ZY-19489 compared to placebo in healthy volunteers.
Malaria
Cadila Healthcare Limited88 enrolled1 locationACTRN12619000127101
Not Yet Recruiting
Phase 1
An efficacy study in humans for chemically attenuated malaria parasites
Malaria
Griffith University36 enrolled1 locationACTRN12618001314213