Metastatic Malignant Neoplasm Clinical Trials

2 recruiting

Metastatic Malignant Neoplasm Trials at a Glance

62 actively recruiting trials for metastatic malignant neoplasm are listed on ClinicalTrialsFinder across 6 cities in 17 countries. The largest study group is Phase 2 with 19 trials, with the heaviest enrollment activity in Houston, Rochester, and Los Angeles. Lead sponsors running metastatic malignant neoplasm studies include M.D. Anderson Cancer Center, Mayo Clinic, and City of Hope Medical Center.

Browse metastatic malignant neoplasm trials by phase

Treatments under study

About Metastatic Malignant Neoplasm Clinical Trials

Looking for clinical trials for Metastatic Malignant Neoplasm? There are currently 2 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Metastatic Malignant Neoplasm trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Metastatic Malignant Neoplasm clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 62 trials

Recruiting
Phase 1Phase 2

Radiation Medication (Radium-223 Dichloride) Versus Radium-223 Dichloride Plus Radiation Enhancing Medication (M3814) Versus Radium-223 Dichloride Plus M3814 Plus Avelumab (a Type of Immunotherapy) for Advanced Prostate Cancer Not Responsive to Hormonal Therapy

Stage IVB Prostate Cancer AJCC v8Metastatic Malignant Neoplasm in the BoneMetastatic Castration-Resistant Prostate Carcinoma+1 more
National Cancer Institute (NCI)90 enrolled32 locationsNCT04071236
Recruiting
Phase 2

Single-Fraction SBRT Versus Standard Palliative Radiation Therapy in Treating Patients With Metastatic Cancer

Metastatic Malignant Neoplasm
Roswell Park Cancer Institute1,500 enrolled3 locationsNCT04068649
Recruiting
Phase 3

Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

Stage IV Lung Cancer AJCC v8Metastatic Malignant Neoplasm in the BrainMetastatic Lung Small Cell Carcinoma+1 more
NRG Oncology200 enrolled227 locationsNCT04804644
Recruiting
Not Applicable

Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial

Metastatic Malignant Solid NeoplasmMetastatic MelanomaMetastatic Renal Cell Carcinoma+15 more
M.D. Anderson Cancer Center40 enrolled1 locationNCT04693377
Recruiting

Blood Tests and Questionnaires in Studying Adherence to Preventative Swallowing Exercises in Participants With Metastatic Head and Neck Cancer

Carcinoma of Unknown PrimaryMetastatic Malignant Neoplasm in the Uterine CervixClinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8+28 more
M.D. Anderson Cancer Center471 enrolled1 locationNCT03010150
Recruiting
Phase 2

SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial

Metastatic Malignant Solid NeoplasmMetastatic Malignant Neoplasm in the Brain
Mayo Clinic90 enrolled7 locationsNCT05222620
Recruiting
Not Applicable

Vertebroplasty With Radiation Therapy for Spine Metastatic Cancer Patients With Indeterminate Lesion (SINS Criteria)

Malignant Solid NeoplasmHematopoietic and Lymphoid Cell NeoplasmMetastatic Malignant Neoplasm in the Spine
Ohio State University Comprehensive Cancer Center200 enrolled1 locationNCT05178472
Recruiting
Phase 2

Robotic Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for Treatment of Gastric Cancer With Limited Peritoneal Metastasis, ROBO-CHIP Study

Gastroesophageal Junction AdenocarcinomaGastric AdenocarcinomaMetastatic Malignant Neoplasm in the Peritoneum
Mayo Clinic40 enrolled1 locationNCT05753306
Recruiting
Phase 3

Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

Anatomic Stage IV Breast Cancer AJCC v8Metastatic Breast CarcinomaMetastatic Lung Non-Small Cell Carcinoma+2 more
NRG Oncology115 enrolled58 locationsNCT06500481
Recruiting
Phase 3

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

Anatomic Stage IV Breast Cancer AJCC v8Metastatic Breast CarcinomaMetastatic Lung Non-Small Cell Carcinoma+7 more
NRG Oncology269 enrolled263 locationsNCT06500455
Recruiting
Not Applicable

Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or Lung Cancer

Anatomic Stage IV Breast Cancer AJCC v8Metastatic Breast CarcinomaStage IV Lung Cancer AJCC v8+2 more
Mayo Clinic5 enrolled1 locationNCT05746325
Recruiting
Phase 3

Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial

Metastatic Colorectal CarcinomaStage IV Colorectal Cancer AJCC v8Unresectable Colorectal Carcinoma+1 more
ECOG-ACRIN Cancer Research Group408 enrolled39 locationsNCT05863195
Recruiting
Phase 1Phase 2

Pulmonary Suffusion in Controlling Minimal Residual Disease in Patients With Sarcoma or Colorectal Metastases

Resectable SarcomaMetastatic Malignant Neoplasm in the LungMetastatic Bone Sarcoma+2 more
Roswell Park Cancer Institute99 enrolled1 locationNCT03965234
Recruiting
Phase 1

Pressurized Intraperitoneal Aerosolized Nab-Paclitaxel in Combination With Gemcitabine and Cisplatin for the Treatment of Biliary Tract Cancer Patients With Peritoneal Metastases

Intrahepatic CholangiocarcinomaGallbladder CarcinomaMetastatic Malignant Neoplasm in the Peritoneum+5 more
City of Hope Medical Center12 enrolled1 locationNCT05285358
Recruiting
Phase 2

Palbociclib and Pembrolizumab In Central Nervous System Metastases

Metastatic Malignant Neoplasm to BrainRecurrent Brain MetastasesProgressive Brain Metastases
Massachusetts General Hospital45 enrolled2 locationsNCT02896335
Recruiting
Phase 1

Intraperitoneal Oxaliplatin and Fluorouracil for the Treatment of Patients With Peritoneal Metastases From Colorectal Cancer

Metastatic Colorectal CarcinomaStage IV Colorectal Cancer AJCC v8Metastatic Malignant Neoplasm in the Peritoneum
Arjun Mittra24 enrolled2 locationsNCT06269978
Recruiting

Patient Perceptions Around Quality of Care Through Telemedicine in Neuro-Oncology

Central Nervous System NeoplasmMetastatic Malignant Neoplasm in the BrainPrimary Brain Neoplasm+1 more
M.D. Anderson Cancer Center200 enrolled1 locationNCT04988009
Recruiting
Phase 2

Gadolinium and Ferumoxytol MRI in Diagnosing Patients With Abnormalities in the Central Nervous System

Central Nervous System NeoplasmMetastatic Malignant Neoplasm in the BrainCranial Nerve Disorder
OHSU Knight Cancer Institute150 enrolled1 locationNCT03270059
Recruiting

Molecular Analysis of Suspected or High-Risk Lung Cancer to Drive Individualized Care (Interception for Suspected Lung Cancer)

Lung CarcinomaMetastatic Malignant Neoplasm in the Lung
Mayo Clinic40 enrolled1 locationNCT06482073
Recruiting
Phase 3

Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

OsteosarcomaMetastatic Malignant Neoplasm in the LungMetastatic Osteosarcoma
Children's Oncology Group62 enrolled232 locationsNCT05235165