Phase 2 Metastatic Malignant Neoplasm Clinical Trials
19 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–19 of 19 trials
Recruiting
Phase 1Phase 2
Radiation Medication (Radium-223 Dichloride) Versus Radium-223 Dichloride Plus Radiation Enhancing Medication (M3814) Versus Radium-223 Dichloride Plus M3814 Plus Avelumab (a Type of Immunotherapy) for Advanced Prostate Cancer Not Responsive to Hormonal Therapy
Stage IVB Prostate Cancer AJCC v8Metastatic Malignant Neoplasm in the BoneMetastatic Castration-Resistant Prostate Carcinoma+1 more
National Cancer Institute (NCI)90 enrolled32 locationsNCT04071236
Recruiting
Phase 2
Single-Fraction SBRT Versus Standard Palliative Radiation Therapy in Treating Patients With Metastatic Cancer
Metastatic Malignant Neoplasm
Roswell Park Cancer Institute1,500 enrolled3 locationsNCT04068649
Recruiting
Phase 2
SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial
Metastatic Malignant Solid NeoplasmMetastatic Malignant Neoplasm in the Brain
Mayo Clinic90 enrolled7 locationsNCT05222620
Recruiting
Phase 2
Robotic Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for Treatment of Gastric Cancer With Limited Peritoneal Metastasis, ROBO-CHIP Study
Gastroesophageal Junction AdenocarcinomaGastric AdenocarcinomaMetastatic Malignant Neoplasm in the Peritoneum
Mayo Clinic40 enrolled1 locationNCT05753306
Recruiting
Phase 1Phase 2
Pulmonary Suffusion in Controlling Minimal Residual Disease in Patients With Sarcoma or Colorectal Metastases
Resectable SarcomaMetastatic Malignant Neoplasm in the LungMetastatic Bone Sarcoma+2 more
Roswell Park Cancer Institute99 enrolled1 locationNCT03965234
Recruiting
Phase 2
Palbociclib and Pembrolizumab In Central Nervous System Metastases
Metastatic Malignant Neoplasm to BrainRecurrent Brain MetastasesProgressive Brain Metastases
Massachusetts General Hospital45 enrolled2 locationsNCT02896335
Recruiting
Phase 2
Gadolinium and Ferumoxytol MRI in Diagnosing Patients With Abnormalities in the Central Nervous System
Central Nervous System NeoplasmMetastatic Malignant Neoplasm in the BrainCranial Nerve Disorder
OHSU Knight Cancer Institute150 enrolled1 locationNCT03270059
Recruiting
Phase 1Phase 2
CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma
Recurrent Malignant Solid NeoplasmRefractory Malignant Solid NeoplasmRecurrent Lymphoma+7 more
Children's Oncology Group63 enrolled34 locationsNCT04870944
Recruiting
Phase 2
Dendritic Cell Vaccines Against Her2/Her3 and Pembrolizumab for the Treatment of Brain Metastasis From Triple Negative Breast Cancer or HER2+ Breast Cancer
Anatomic Stage IV Breast Cancer AJCC v8Metastatic Triple-Negative Breast CarcinomaPrognostic Stage IV Breast Cancer AJCC v8+1 more
Roswell Park Cancer Institute23 enrolled3 locationsNCT04348747
Recruiting
Phase 2
Intensity Modulated Proton or X-Ray Therapy After Surgery for Treatment of Head and Neck Cancer, the HEADLIGHT Study
Head and Neck CarcinomaSalivary Gland CarcinomaMetastatic Malignant Neoplasm in the Lymph Nodes+9 more
Mayo Clinic174 enrolled9 locationsNCT05075980
Recruiting
Phase 1Phase 2
Panitumumab-IRDye800 in Detecting Cancer in Participants With Lung Cancer During Surgery
Lung CarcinomaStage IV Lung Cancer AJCC v8Stage IVA Lung Cancer AJCC v8+2 more
Stanford University30 enrolled1 locationNCT03582124
Recruiting
Phase 1Phase 2
Phase I/II Randomized Study of NBTXR3 Activated by Abscopal or RadScopal Radiation in Combination With Immunotherapy (Anti-PD-1/L-1) for Patients With Advanced Solid Malignancies
Metastatic Malignant Solid NeoplasmAdvanced Malignant Solid NeoplasmMetastatic Malignant Neoplasm in the Liver+1 more
M.D. Anderson Cancer Center40 enrolled1 locationNCT05039632
Recruiting
Phase 1Phase 2
Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Brain
Clinical Stage IV Cutaneous Melanoma AJCC v8Metastatic MelanomaPathologic Stage IV Cutaneous Melanoma AJCC v8+1 more
Kari Kendra30 enrolled1 locationNCT05588453
Recruiting
Phase 2
Hyperthermic Intraperitoneal Chemotherapy for the Treatment of Pancreatic Cancer and Peritoneal Metastasis
Metastatic Pancreatic CarcinomaStage IV Pancreatic Cancer AJCC v8Metastatic Malignant Neoplasm in the Peritoneum
Mayo Clinic40 enrolled1 locationNCT04858009
Recruiting
Phase 2
Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors
Pancreatic Neuroendocrine TumorMetastatic Malignant Neoplasm in the LiverStage III Pancreatic Neuroendocrine Tumor AJCC v8+2 more
SWOG Cancer Research Network141 enrolled448 locationsNCT05040360
Recruiting
Phase 2
Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer
Anatomic Stage IV Breast Cancer AJCC v8Metastatic Breast CarcinomaMetastatic Lung Non-Small Cell Carcinoma+2 more
University of Washington22 enrolled2 locationsNCT06518057
Recruiting
Phase 2
Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer
Anatomic Stage IV Breast Cancer AJCC v8Metastatic Breast CarcinomaMetastatic Lung Non-Small Cell Carcinoma+2 more
City of Hope Medical Center35 enrolled2 locationsNCT06910761
Recruiting
Phase 2
Short Stitch Versus Traditional Suture for the Prevention of Incisional Hernia After Open Hepatectomy
Metastatic Malignant Neoplasm in the LiverLiver and Intrahepatic Bile Duct NeoplasmPrimary Malignant Liver Neoplasm
M.D. Anderson Cancer Center140 enrolled1 locationNCT04982653
Recruiting
Phase 2
A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases
Clinical Stage IV Cutaneous Melanoma AJCC v8Metastatic MelanomaPathologic Stage IV Cutaneous Melanoma AJCC v8+4 more
SWOG Cancer Research Network112 enrolled331 locationsNCT04511013