Phase 1 Neuroblastoma Clinical Trials
41 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 41 trials
Recruiting
Phase 1Phase 2
Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors
OsteosarcomaEwing SarcomaNeuroblastoma+10 more
University of Florida27 enrolled1 locationNCT06625190
Recruiting
Phase 1Phase 2
Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)
Diffuse Large B Cell LymphomaEwing SarcomaNeuroblastoma+2 more
Merck Sharp & Dohme LLC90 enrolled66 locationsNCT06395103
Recruiting
Phase 1Phase 2
Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors
OsteosarcomaEwing SarcomaNeuroblastoma+2 more
Milton S. Hershey Medical Center104 enrolled20 locationsNCT06541262
Recruiting
Phase 1Phase 2
Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas
OsteosarcomaEwing SarcomaNeuroblastoma+3 more
Milton S. Hershey Medical Center289 enrolled6 locationsNCT06465199
Recruiting
Phase 1
A Study of Avutometinib for People With Solid Tumor Cancers
Solid TumorSolid Tumor, AdultNeuroblastoma+12 more
Memorial Sloan Kettering Cancer Center23 enrolled2 locationsNCT06104488
Recruiting
Phase 1Phase 2
Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
Ovarian CarcinomaColorectal CarcinomaMelanoma+19 more
Children's Oncology Group147 enrolled21 locationsNCT04851119
Recruiting
Phase 1
Phase I Trial of rhIL-15 Plus Dinutuximab Plus Irinotecan/Temozolomide for Children and Young Adults With Relapsed/Refractory Neuroblastoma
Neuroblastoma
National Cancer Institute (NCI)34 enrolled1 locationNCT06995872
Recruiting
Phase 1Phase 2
SPEARHEAD-3 Pediatric Study
OsteosarcomaSynovial SarcomaMalignant Peripheral Nerve Sheath Tumor (MPNST)+1 more
USWM CT, LLC20 enrolled10 locationsNCT05642455
Recruiting
Phase 1Phase 2
Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma
Recurrent Malignant Solid NeoplasmRefractory Malignant Solid NeoplasmRecurrent Solid Tumor+19 more
St. Jude Children's Research Hospital90 enrolled10 locationsNCT04901702
Recruiting
Phase 1Phase 2
Apatinib Mesylate Combined With IT Regimen for the Treatment of Recurrent or Refractory Pediatric Neuroblastoma: A Single-arm, Phase I/II，Multi-center, Clinical Study.
Neuroblastoma
Sun Yat-sen University125 enrolled1 locationNCT05027386
Recruiting
Phase 1Phase 2
An Imaging Study of Anti-GD2-800CW in Patients With Neuroblastoma
Neuroblastoma
Princess Maxima Center for Pediatric Oncology22 enrolled1 locationNCT07399821
Recruiting
Phase 1
GPC2-CAR T Cell Therapy for Relapsed or Refractory Medulloblastoma in Children and Young Adults
Pediatric Brain TumorPineoblastomaMedulloblastoma+7 more
Stanford University18 enrolled1 locationNCT07087002
Recruiting
Phase 1
Selective Antigen Specific T Cells and CAR T Cells in Subjects With Relapsed/Refractory Embryonal Tumors (SABRE)
Ewing SarcomaNeuroblastomaRhabdomyosarcoma+1 more
Children's National Research Institute18 enrolled2 locationsNCT07172958
Recruiting
Phase 1Phase 2
A Multi-Arm, Platform Trial For Relapsed Neuroblastoma
Relapsed Neuroblastoma
University of Birmingham160 enrolled23 locationsNCT07334301
Recruiting
Phase 1Phase 2
Study of hALK.CAR T Cells for Patients With Relapsed/Refractory High-risk Neuroblastoma
High Risk NeuroblastomaRefractory NeuroblastomaRelapsed Neuroblastoma
Roberto Chiarle42 enrolled2 locationsNCT06803875
Recruiting
Phase 1
GPC2 CAR T Cells for Relapsed or Refractory Neuroblastoma and Metastatic Retinoblastoma
High Risk NeuroblastomaRetinoblastomaRefractory Neuroblastoma+2 more
Stephan Grupp MD PhD45 enrolled1 locationNCT05650749
Recruiting
Phase 1
PHOX2B PC-CAR T Cells for Relapsed Neuroblastoma
High Risk NeuroblastomaRefractory NeuroblastomaRelapsed Neuroblastoma
Stephan Grupp MD PhD38 enrolled1 locationNCT07007117
Recruiting
Phase 1
Allogeneic Expanded Gamma Delta T Cells With GD2 Chemoimmunotherapy in Relapsed /Refractory Neuroblastoma or Refractory/ Relapsed Osteosarcoma
NeuroblastomaRefractory OsteosarcomaRefractory Neuroblastoma+2 more
Emory University24 enrolled1 locationNCT05400603
Recruiting
Phase 1
Clinical Trial of GAIA-102 for Refractory/Relapse Neuroblastomas and Other Malignant Pediatric Solid Tumors
Pediatric Solid TumorsRefractory/Relapse Neuroblastoma
Kyushu University61 enrolled1 locationNCT05608148
Recruiting
Phase 1
A Clinical Study Evaluating the Safety of Peptide Receptor Radionuclide Therapy (PRRT) With 177Lu-DOTA0-Tyr3-Octreotate in Children With Refractory or Recurrent Neuroblastoma Expressing Somatostatin Receptors.
Neuroblastoma
Institut Claudius Regaud18 enrolled14 locationsNCT03966651