Neurocognitive Disorder Clinical Trials

58 recruitingLast updated: June 17, 2026

There are 58 actively recruiting neurocognitive disorder clinical trials across 32 countries. Studies span Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3. Top locations include Toronto, Ontario, Canada, Beijing, China, Montreal, Quebec, Canada. Updated daily from ClinicalTrials.gov.


Neurocognitive Disorder Trials at a Glance

58 actively recruiting trials for neurocognitive disorder are listed on ClinicalTrialsFinder across 6 cities in 32 countries. The largest study group is Not Applicable with 25 trials, with the heaviest enrollment activity in Toronto, Beijing, and Montreal. Lead sponsors running neurocognitive disorder studies include Xuanwu Hospital, Beijing, Sunnybrook Health Sciences Centre, and Centre Hospitalier Universitaire de Nice.

Browse neurocognitive disorder trials by phase

Treatments under study

About Neurocognitive Disorder Clinical Trials

Looking for clinical trials for Neurocognitive Disorder? There are currently 4 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Neurocognitive Disorder trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Neurocognitive Disorder clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 58 trials

Recruiting
Phase 2

Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV

Mild Neurocognitive DisorderMajor Depressive DisorderHIV
National Institute of Allergy and Infectious Diseases (NIAID)186 enrolled41 locationsNCT06705478
Recruiting

POCD After Major Gynecologic Surgery

Postoperative Cognitive DysfunctionPerioperative Neurocognitive Disorder
Fatihhan Zeytun72 enrolled1 locationNCT07589348
Recruiting
Not Applicable

Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia

DementiaAlzheimer DiseaseCommunication Disorders+11 more
Stephanie Grasso60 enrolled3 locationsNCT05741853
Recruiting

The Effects of Anesthesia on Postoperative Cognitive Functions in Patients Undergoing Sleeve Gastrectomy

Postoperative Neurocognitive DisorderCognitive FunctionsTotal Intravenous Anesthesia+6 more
Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital60 enrolled1 locationNCT07637357
Recruiting

Evaluation of the Link Between Carotid Arterial Wall Viscosity and Major Neurocognitive Disorders

Neurocognitive DisordersAlzheimer's Disease
University Hospital, Rouen140 enrolled1 locationNCT07205003
Recruiting
Not Applicable

Brain Stimulation and Cognitive Training for MCI

Mild Neurocognitive DisorderCognitive DysfunctionMild Cognitive Impairment (MCI)+2 more
Medical University of South Carolina50 enrolled1 locationNCT07526740
Recruiting

Integration of Neurocognitive Biomarkers Into a Neuro-Oncology Clinic

Neurocognitive Disorders
Baptist Health South Florida200 enrolled1 locationNCT05504681
Recruiting
Not Applicable

Digital Sleep Optimization for Brain Health Outcomes in Older Surgical Patients

Postoperative Neurocognitive DisorderInsomniaPostoperative Delirium+1 more
Massachusetts General Hospital50 enrolled1 locationNCT06375265
Recruiting
Not Applicable

Creation of an Ecological Tool Assessing Episodic Memory in Geriatrics

Memory DisordersNeurocognitive Disorders
Centre Hospitalier de Lens60 enrolled1 locationNCT05668598
Recruiting

Cognitive Disorders and Brain Pulse

Neurocognitive Disorders
University Hospital, Tours300 enrolled1 locationNCT05129150
Recruiting
Not Applicable

Endovascular Therapy Versus Best Medical Treatment for Acute Large Vessel Occlusion Stroke With Low NIHSS

Mild Neurocognitive DisorderThrombectomyAcute Ischemic Stroke
First Affiliated Hospital of Wannan Medical College264 enrolled1 locationNCT06143488
Recruiting
Not Applicable

Study to Evaluate the Efficacy and Safety of ATNC-MDD V1(TMS With Cognitive Training) in Mild Alzheimer's Dementia

DementiaBrain DiseasesCentral Nervous System Diseases+5 more
Advanced Technology & Communications180 enrolled11 locationsNCT06088121
Recruiting
Phase 2

Fisetin in Mild Alzheimer's Disease

Alzheimer DiseaseAlzheimer DementiaAlzheimer Dementia (AD)+4 more
Sunnybrook Health Sciences Centre5 enrolled1 locationNCT07279714
Recruiting
Not Applicable

rTMS for Apathy Clinical Trial

DementiaAlzheimer DiseaseMild Cognitive Impairment+3 more
Sunnybrook Health Sciences Centre10 enrolled1 locationNCT05561205
Recruiting

The Role of Neuroinflammation on Neurocognitive Outcome in Cardiac Surgery

Postoperative Neurocognitive DisorderQuality of recoveryElderly Patients+5 more
Ziekenhuis Oost-Limburg80 enrolled1 locationNCT07200726
Recruiting
Not Applicable

Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging

Cognitive ChangeAgingNeurocognitive Disorders, Mild
University of Florida68 enrolled1 locationNCT05457725
Recruiting
Phase 3

A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5)

DementiaBrain DiseasesCentral Nervous System Diseases+6 more
Eli Lilly and Company1,500 enrolled141 locationsNCT05508789
Recruiting
Not Applicable

Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders

Patient SatisfactionAlzheimer DiseaseCaregiver Burden+7 more
University of Michigan1,900 enrolled7 locationsNCT05929703
Recruiting

CONCEPTT Kids International Neurodevelopmental Outcomes Among Offspring of Women With Type 1 Diabetes

Neurocognitive Disorders
University of Manitoba225 enrolled10 locationsNCT05754567
Recruiting

Early Detection of Alzheimer's Disease and Affective Disorders by Automated Voice and Speech Analysis (PLATA)

Neurocognitive Disorders
Centre Hospitalier Universitaire de Nice100 enrolled1 locationNCT05943834