Phase 1 Obstructive Clinical Trials
34 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 34 trials
Recruiting
Phase 1Phase 2
Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia
Hypoxia, BrainBlood PressureStroke+5 more
University of Calgary12 enrolled1 locationNCT03255408
Recruiting
Phase 1Phase 2
Feasibility of Semaglutide in Advanced Lung Disease
ObesityChronic Obstructive Pulmonary DiseaseInterstitial Lung Disease+2 more
University of Pennsylvania8 enrolled1 locationNCT05746039
Recruiting
Phase 1Phase 2
Efficacy of Morphine in Reducing the Rate of Early Non-Invasive Ventilation Failure in Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Phase I/IIa
Chronic Obstructive Pulmonary Disease
University Hospital, Grenoble24 enrolled1 locationNCT04427826
Recruiting
Phase 1Phase 2
A Study to Test the Safety and Effects of Inhaled GDC-6988 in Participants With Muco-obstructive Disease
Chronic Obstructive Pulmonary DiseaseNon-cystic Fibrosis Bronchiectasis
Genentech, Inc.128 enrolled7 locationsNCT06603246
Recruiting
Phase 1Phase 2
cfMSC Stem Cell Therapy Targeting COPD
Chronic Obstructive Pulmonary Disease (COPD)
Shenzhen Geno-Immune Medical Institute30 enrolled1 locationNCT07477600
Recruiting
Phase 1
A Clinical Study to Evaluate the Safety, Tolerability and Pharmacokinetic Profile of TQC3302 Inhalation Spray in Healthy Adult Subjects
Chronic Obstructive Pulmonary Disease
Chia Tai Tianqing Pharmaceutical (Guangzhou) Co., Ltd.57 enrolled1 locationNCT07267130
Recruiting
Phase 1Phase 2
Atomoxetine and DAW2022 on OSA Severity
Obstructive Sleep Apnea
Brigham and Women's Hospital18 enrolled1 locationNCT05350215
Recruiting
Phase 1Phase 2
Low-Tech Treatments for Obstructive Sleep Apnea
Traumatic Brain Injury (TBI)Obstructive Sleep Apnea (OSA)
Uniformed Services University of the Health Sciences60 enrolled1 locationNCT07301710
Recruiting
Phase 1
Vascular Endothelial Dysfunction in Sleep Apnea
Obstructive Sleep Apnea of Adult
Columbia University110 enrolled1 locationNCT05289063
Recruiting
Phase 1
Investigation of Small Mobile Stem Cells (SMS Cells) in Participants With Chronic Obstructive Pulmonary Disease (COPD).
Chronic Obstructive Lung Disease
SMSbiotech18 enrolled2 locationsNCT06986070
Recruiting
Phase 1
A Study of BBT002 in Healthy Volunteers (HVs) and in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Chronic Obstructive Pulmonary Disease (COPD)
Bambusa Therapeutics68 enrolled11 locationsNCT07288554
Recruiting
Phase 1Phase 2
Intermittent Hypoxia-initiated Plasticity in Humans: A Multi-pronged Therapeutic Approach to Treat Sleep Apnea and Overlapping Co-morbidities
Obstructive Sleep Apnea
VA Office of Research and Development60 enrolled1 locationNCT05558501
Recruiting
Phase 1
Serial Amnioinfusions as Regenerative Therapy for Pulmonary Hypoplasia
Lower Urinary Tract Obstructive SyndromeRenal Failure CongenitalCongenital Renal Anomaly Nos+1 more
Mayo Clinic40 enrolled1 locationNCT03723564
Recruiting
Phase 1
Study Targeting Myocardial Perfusion and Symptom Relief in Women With SGLT2 Inhibitors (STRONG)
Angina Patients With Non-obstructive Coronary Artery Disease
University of Virginia150 enrolled1 locationNCT06600178
Recruiting
Phase 1
: Vascular Function in Health and Disease
Heart FailureHypertensionChronic Obstructive Pulmonary Disease+1 more
Russell Richardson420 enrolled1 locationNCT02966665
Recruiting
Phase 1Phase 2
DRonabinol Treatment of OSA
Obstructive Sleep Apnea
VA Office of Research and Development120 enrolled1 locationNCT06477952
Recruiting
Phase 1
Use of Passive Myofunctional Appliances for Snoring and Mild Obstructive Sleep Apnea
Sleep Apnea, Obstructive
University of Alberta40 enrolled1 locationNCT05497180
Recruiting
Phase 1
A Study for GSK3862995B in Healthy Participants and Participants With Chronic Obstructive Pulmonary Disease
Pulmonary Disease, Chronic Obstructive
GlaxoSmithKline130 enrolled32 locationsNCT06154837
Recruiting
Phase 1
A Study of BBT002 in Healthy Volunteers (HVs) and in Adult Patients With Chronic Obstructive Pulmonary Disease (COPD)
Chronic Obstructive Pulmonary Disease
Bambusa Therapeutics98 enrolled1 locationNCT06944925
Recruiting
Phase 1
Exploring the Use of Phototherapy to Improve CPAP Compliance
Obstructive Sleep Apnea
University of Alberta30 enrolled1 locationNCT06960161