orthopedic Clinical Trials

43 recruitingLast updated: May 13, 2026

There are 43 actively recruiting orthopedic clinical trials across 18 countries. Studies span Not Applicable, Phase 3, Phase 4, Phase 2. Top locations include Boston, Massachusetts, United States, Cairo, Egypt, Milan, Italy. Updated daily from ClinicalTrials.gov.


orthopedic Trials at a Glance

43 actively recruiting trials for orthopedic are listed on ClinicalTrialsFinder across 6 cities in 18 countries. The largest study group is Not Applicable with 21 trials, with the heaviest enrollment activity in Boston, Cairo, and Milan. Lead sponsors running orthopedic studies include Cairo University, I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio, and Ain Shams University.

Browse orthopedic trials by phase

Treatments under study

About orthopedic Clinical Trials

Looking for clinical trials for orthopedic? There are currently 1 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new orthopedic trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about orthopedic clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 43 trials

Recruiting
Not Applicable

Intrathecal Dexmedetomidine With Bupivacaine, in Patients Undergoing Knee Orthopedic Surgery

BupivacaineIntrathecal DexmedetomidineKnee Orthopedic Surgery
Cairo University120 enrolled1 locationNCT07522736
Recruiting

Adherence to Home-Based Exercises in Musculoskeletal Disorders

Musculoskeletal DiseaseExercise TrainingStroke+6 more
Konya Beyhekim Training and Research Hospital252 enrolled1 locationNCT07261553
Recruiting
Phase 4

Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients

Opioid UsePostoperative PainDepression+2 more
Texas Tech University Health Sciences Center90 enrolled2 locationsNCT06903819
Recruiting
Not Applicable

Web-based Mind-body Program to Improve Resilience Among Risky Substance Users With Persistent Upper Extremity Pain

Orthopedic DisorderNontraumatic InjuryUpper Extremity Pain+1 more
Jafar Bakhshaie50 enrolled1 locationNCT06991205
Recruiting

The Duration of Spinal Anaesthesia - a Prospective, Observational Cohort Study

Orthopedic Disorder
Nordsjaellands Hospital2,000 enrolled2 locationsNCT06459986
Recruiting

The Effect of Bruxism on Balance

BruxismOrthopedic Physical Therapy
Istinye University54 enrolled1 locationNCT07308145
Recruiting

Femoral Vein Diameter to Predict Intraoperative Hypotension in Geriatric Patients Undergoing Orthopedic Surgery Under Spinal Anesthesia

Intraoperative hypotensionSpinal AnesthesiaOrthopedic Surgery+1 more
Cairo University43 enrolled1 locationNCT07339475
Recruiting

Evaluation of Cerebral Oxygenation During Orthopedic Surgeries Performed in the Beach Chair Position Under General Anesthesia

Cerebral PerfusionCerebral OxygenationHemodynamic Monitoring+2 more
Akdeniz University40 enrolled2 locationsNCT07270341
Recruiting

Pediatric Orthopaedic Implant Safety & Efficacy

Pediatric ALLFractureLengthening; Leg+8 more
University of British Columbia4,000 enrolled1 locationNCT05361980
Recruiting
Not Applicable

Tranexamic Acid in Pediatric Undergoing Proximal Femoral Osteotomies and/or Acetabular Osteotomy

Orthopedic DisorderPediatricIntraoperative Blood loss.
Assiut University400 enrolled1 locationNCT04811313
Recruiting
Not Applicable

Right-Size Clinic Visits Using Memora Platform for PROMIS

Orthopedic Disorders
Boston Medical Center3,000 enrolled1 locationNCT04441567
Recruiting
Phase 3

Remimazolam vs. Midazolam for Sedation and Cognitive Outcomes in Orthopedic Surgery

Postoperative Pain ManagementPostoperative Cognitive DysfunctionHip Fracture+1 more
Romanian Society for Enteral and Parenteral Nutrition120 enrolled1 locationNCT07113483
Recruiting

CERAMENT™| Bone Void Filler Device Registry

Orthopedic Disorder
BONESUPPORT AB300 enrolled13 locationsNCT04244942
Recruiting

Clinical and Radiological Evaluation of Total Ankle Replacement (ProtesiTT)

Orthopedic Disorder
I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio100 enrolled1 locationNCT07168330
Recruiting

Hand & Wrist Pyrocarbon Implants Outcomes Clinical Study

Orthopedics
Stryker Trauma and Extremities417 enrolled4 locationsNCT04137237
Recruiting

SupraScapular Cuff Study: Assessing the Effects of Size and Type of Rotator Cuff Tear on Suprascapular Nerve Function

Orthopedic Disorder
University Hospitals of North Midlands NHS Trust250 enrolled1 locationNCT06002009
Recruiting
Not Applicable

Pre-operative Inspiratory Muscle Strength Training in Total Joint Surgery

Orthopedic DisorderArthropathy of KneeLower Extremity Fracture+1 more
University of Florida36 enrolled1 locationNCT05381818
Recruiting
Not Applicable

A Study to Compare Early and Partial Weight-bearing After Hallux Valgus Surgery

Hallux ValgusOrthopedic Disorder
Ente Ospedaliero Cantonale, Bellinzona122 enrolled1 locationNCT05534724
Recruiting
Not Applicable

TRabecular Metal Economic and Clinical Knee Trial

OrthopedicsTotal Knee Replacement
NHS Greater Glasgow and Clyde144 enrolled1 locationNCT04677907
Recruiting
Not Applicable

Ketamine for Preventing Post-Spinal Hypotension in Orthopedic Surgery

Orthopedic SurgeryPost-spinal HypotensionSpinal Aneshtesia
Ain Shams University30 enrolled1 locationNCT06995690