Acute Pain Clinical Trials

47 recruitingLast updated: June 19, 2026

There are 47 actively recruiting acute pain clinical trials across 18 countries. Studies span Not Applicable, Phase 4, Phase 2, Phase 3, Early Phase 1. Top locations include Newark, New Jersey, United States, Tallahassee, Florida, United States, Cairo, Egypt. Updated daily from ClinicalTrials.gov.


Acute Pain Trials at a Glance

47 actively recruiting trials for acute pain are listed on ClinicalTrialsFinder across 6 cities in 18 countries. The largest study group is Not Applicable with 26 trials, with the heaviest enrollment activity in Newark, Tallahassee, and Cairo. Lead sponsors running acute pain studies include Florida State University, Rutgers, The State University of New Jersey, and Samsun University.

Browse acute pain trials by phase

Treatments under study

About Acute Pain Clinical Trials

Looking for clinical trials for Acute Pain? There are currently 45 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Acute Pain trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Acute Pain clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 47 trials

Recruiting
Not Applicable

Conditioned Open-label Placebos to Facilitate Opioid Reduction in Patients With Subacute or Chronic Pain Pain: a Randomized Controlled Trial

Chronic PainSubacute Pain
Cosima Locher86 enrolled1 locationNCT06350786
Recruiting
Not Applicable

Ultrasound-Guided Regional Blocks for Postoperative Analgesia After Laparoscopic Cholecystectomy

Pain ManagementLaparoscopic CholecystectomyAcute Pain+1 more
Istanbul Medipol University Hospital90 enrolled1 locationNCT07321639
Recruiting
Not Applicable

Comparison of IV Analgesia Protocols After the Regional Block's Effect Diminishes in Thoracic Surgery

Postoperative PainThoracic Surgery, Video-assistedPatient-controlled Analgesia+2 more
Ankara Etlik City Hospital135 enrolled1 locationNCT07610408
Recruiting
Not Applicable

The 50:50 Nitrous Oxide vs 2% Lidocaine Challenge

AnxietyAcute PainCentral Venous Catheter
Institute for Oncology and Radiology of Serbia62 enrolled1 locationNCT07618676
Recruiting

Understanding the Acute Pain Phenotype in Patients Undergoing Surgery

Opioid UseAcute PainChronic post operative pain
Brigham and Women's Hospital1,000 enrolled1 locationNCT06466941
Recruiting
Not Applicable

Comparative Analysis of the Impact of Transversus Abdominis Plane Block on Post-Cesarean Pain Management Using Low Concentration Ropivacaine 0,2%

Postoperative acute painPostoperative Pain
Matild Keresztes70 enrolled1 locationNCT07604376
Recruiting
Phase 2

A Study of LY4515100 in Participants With Pain Following Third Molar Removal

Acute PainMolar, ThirdMolar+1 more
Eli Lilly and Company212 enrolled1 locationNCT07511816
Recruiting
Early Phase 1

The Role of NaV1.8 in Human Pain Models

PainHealthy Volunteer StudyAcute Pain
Medical University of Vienna66 enrolled1 locationNCT07511400
Recruiting
Not Applicable

Comparing the Postoperative Analgesic Efficacy of Anterior Iliac Block and Ilioinguinal-iliohypogastric Block in Inguinal Hernia Surgery

Acute Pain
Harran University60 enrolled1 locationNCT07290881
Recruiting
Not Applicable

Does Patient Testimonial Improve the Pain Relief Derived From a Brief Intervention

PainPain ManagementChronic Pain+1 more
Florida State University400 enrolled1 locationNCT07335159
Recruiting
Not Applicable

Virtual Reality Intervention to Reduce Pain in Women Undergoing Elective Oocyte Cryopreservation

Acute PainProcedure-Related Pain
Hadassah Medical Organization100 enrolled1 locationNCT07484815
Recruiting
Not Applicable

Comparison of Erector Spinae Plane Block (ESPB) With the Combination of Superficial Parasternal Intercostal Plane Block (SPIPB) and Serratus Anterior Plane Block (SAPB) in the Management of Postoperative Sternotomy Pain in Patients Undergoing Cardiac Surgery Via Sternotomy

Pain ManagementPostoperative PainCardiac Surgery+2 more
Uludag University50 enrolled1 locationNCT07472296
Recruiting
Not Applicable

Clinical Utility of the Numerical Verbal Scale (NVS) and the Pain and Functional Activity Scale (PFAS) in the Management of Rescue Analgesia in Acute Postoperative Pain. Randomized Study.

Post Operative PainAnalgesiaAcute Pain+1 more
Fundacin Biomedica Galicia Sur76 enrolled1 locationNCT07310953
Recruiting

Dexmedetomidine and Dexamethasone Added as Adjuvant Infraclavicular Brachial Plexus Block in Upper Limb Surgery

Post Operative PainAnesthesiaAcute Pain
Umraniye Education and Research Hospital44 enrolled1 locationNCT06779604
Recruiting
Not Applicable

Acute Effects of LLLT on Pain Threshold and Pain Tolerance

Pain ThresholdAcute PainLow-Level Laser Therapy+2 more
European University of Lefke52 enrolled1 locationNCT07422272
Recruiting
Phase 2

Effects Of Intravenous Oxytocin On Peripheral Sensory Afferents Using Microneurography

Acute Pain
Wake Forest University Health Sciences60 enrolled1 locationNCT07409753
Recruiting
Not Applicable

Quadro-Iliac vs Thoracolumbar Interfascial Plane Block for Analgesia After Single-Level Lumbar Disc Surgery

Spinal StenosisAcute Pain
Samsun University70 enrolled1 locationNCT07348419
Recruiting
Not Applicable

Comparison of the Postoperative Analgesic Efficacy of Classical and Modified Erector Spinae Plane Blocks After Lumbar Spinal Surgery

Acute PainSpinal Stenosis Lumbar
Samsun University60 enrolled1 locationNCT07348523
Recruiting
Not Applicable

Acute Preoperative Pain and Chronic Post-surgical Pain in Emergency Surgery

Emergency surgeryPostoperative PainRisk Factors+3 more
Centre Hospitalier Universitaire, Amiens693 enrolled1 locationNCT06555107
Recruiting

Characterization of Acute Pain

Postoperative PainAcute PainAcute Pain, Postoperative
Children's National Research Institute100 enrolled1 locationNCT07336264