Phase 1 Overweight Clinical Trials
72 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 72 trials
Recruiting
Phase 1
A Study in People With Overweight or Obesity to Compare How 2 Different Formulations of Survodutide Are Taken up by the Body
ObesityHealthyOverweight
Boehringer Ingelheim80 enrolled1 locationNCT07407348
Recruiting
Phase 1
A Study to Evaluate the Safety and Tolerability of Different Doses of CX11 Tablets
Obesity, Overweight
Corxel Pharmaceuticals90 enrolled2 locationsNCT07652047
Recruiting
Phase 1Phase 2
A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM
Type 2 Diabetes Mellitus (T2DM)Obese or Overweight Healthy Volunteers
Alnylam Pharmaceuticals144 enrolled22 locationsNCT06845202
Recruiting
Phase 1
A Study of Multiple Doses of Orally Administered RO7795081 in Otherwise Healthy Chinese Adult Participants With Obesity or Overweight
Healthy VolunteersOverweight or Obesity
Hoffmann-La Roche30 enrolled2 locationsNCT07499050
Recruiting
Phase 1
A Study Investigating the Safety of RO7795081 and the Effect of RO7795081 on How the Body Processes Pitavastatin and Rosuvastatin in Otherwise Healthy Overweight or Obese Adult Participants
ObesityOverweight
Hoffmann-La Roche40 enrolled1 locationNCT06982131
Recruiting
Phase 1
A Research Study Investigating How a New Medicine NNC0113-5840 Works in People With Overweight or Obesity
ObesityOverweight
Novo Nordisk A/S48 enrolled1 locationNCT07566390
Recruiting
Phase 1
A Research Study Investigating the Effect of NNC0497-0040 in Healthy Participants, Participants With Overweight or Obesity, and Participants With Type 1 Diabetes With Overweight or Obesity
ObesityHealthy VolunteersOverweight+1 more
Novo Nordisk A/S146 enrolled1 locationNCT07578584
Recruiting
Phase 1Phase 2
A Phase 1/2a Study of WVE-007 in Adults Living With Overweight or Obesity
Overweight and Obesity
Wave Life Sciences USA, Inc.296 enrolled6 locationsNCT06842186
Recruiting
Phase 1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Single Dose of IBIO-600 in Overweight or Obese Adults
Overweight/Obesity
iBio, Inc.32 enrolled1 locationNCT07487376
Recruiting
Phase 1
Study of ALV-100 to Assess Safety, Tolerability, and PK/PD in Overweight/Obese Participants With or Without T2D
Overweight or Obese AdultsOverweight or Obese, Type 2 Diabetes
Alveus Therapeutics, Inc.180 enrolled2 locationsNCT07399678
Not Yet Recruiting
Phase 1
A trial to assess the safety, tolerability and efficacy of RES-010 in overweight and obese adults without obesity-related comorbidities.
OverweightObesity (Mild)
Resalis Therapeutics Australia Pty Ltd36 enrolled1 locationACTRN12626000615381
Recruiting
Phase 1
A Research Study Looking Into How Cagrilintide Influences Food Intake and Appetite in People With Overweight or Obesity
ObesityOverweight
Novo Nordisk A/S120 enrolled1 locationNCT07557953
Recruiting
Phase 1Phase 2
Pilot Testing a Novel Approach to Pediatric Obesity Treatment
Obese AdolescentsOverweight Adolescents
Texas Tech University30 enrolled1 locationNCT06755827
Recruiting
Phase 1
A Study of SHR-2906 Injection in Healthy Subjects With a Single Dose and in Obese Patients With Multiple Doses
ObesityOverweight
Beijing Suncadia Pharmaceuticals Co., Ltd124 enrolled1 locationNCT07280936
Recruiting
Phase 1
A Study of LY4086940 in Healthy Participants and Participants With Overweight or Obesity, With or Without Type 2 Diabetes
ObesityHealthyOverweight+1 more
Eli Lilly and Company216 enrolled5 locationsNCT06945419
Recruiting
Phase 1Phase 2
A Trial to Learn How Safe AZD9550 Monotherapy and Combined With AZD6234 is in People With or Without Type 2 Diabetes Who Are Living With Obesity and Overweight
Overweight and Obesity
AstraZeneca160 enrolled15 locationsNCT06151964
Not Yet Recruiting
Phase 1
A First-in-Human, Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single and Multiple Ascending Dose Study on the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of EBMC-710GO in Healthy Adults who are Overweight or have Obesity
ObesityOverweight
Kalohexis120 enrolled1 locationACTRN12626000541303
Not Yet Recruiting
Phase 1
A First-in-Human, Phase 1, Open-Label, Crossover Study Evaluating the Effect of Food on the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of EBMC-710GO in Healthy Adults who are Overweight or have Obesity
ObesityOverweight
Kalohexis12 enrolled1 locationACTRN12626000540314
Recruiting
Phase 1
A Study of SYNT-101 to Test Safety, Tolerability and Pharmacodynamics of SYNT-101 in Healthy and Overweight Adults
HealthyOverweight and Obese Adults
Syntis Bio64 enrolled1 locationNCT07307274
Recruiting
Phase 1
Effect of Maridebart Cafraglutide on How Oral Contraceptives Are Absorbed and Processed in the Body in Postmenopausal Female Participants Living With Overweight or Obesity
ObesityOverweight
Amgen45 enrolled3 locationsNCT07523711