Phase 1 Overweight Clinical Trials
57 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 57 trials
Recruiting
Phase 1
A Study of SYNT-101 to Test Safety, Tolerability and Pharmacodynamics of SYNT-101 in Healthy and Overweight Adults
HealthyOverweight and Obese Adults
Syntis Bio64 enrolled1 locationNCT07307274
Recruiting
Phase 1
Effect of Maridebart Cafraglutide on How Oral Contraceptives Are Absorbed and Processed in the Body in Postmenopausal Female Participants Living With Overweight or Obesity
ObesityOverweight
Amgen45 enrolled3 locationsNCT07523711
Recruiting
Phase 1
A Research Study Looking Into How NNC0662-0419 Works With Birth Control Pills and Emptying of the Stomach in Women Not Able to Become Pregnant With Excess Body Weight
ObesityOverweight
Novo Nordisk A/S45 enrolled1 locationNCT07525791
Recruiting
Phase 1
A Study to Learn About the Effect of Study Medicine Called PF-08653944 on How Quickly the Stomach Empties Its Content in Healthy Adults With Overweight or Obesity
ObesityOverweightDrug Interaction+1 more
Pfizer20 enrolled1 locationNCT07508241
Recruiting
Phase 1
A Study of LY4064912 in Healthy Participants and With Overweight or Obesity
HealthyOverweight or Obesity
Eli Lilly and Company144 enrolled3 locationsNCT07152002
Recruiting
Phase 1
A Study of LY4086940 in Healthy Participants and Participants With Overweight or Obesity, With or Without Type 2 Diabetes
ObesityHealthyOverweight+1 more
Eli Lilly and Company216 enrolled6 locationsNCT06945419
Recruiting
Phase 1Phase 2
A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM
Type 2 Diabetes Mellitus (T2DM)Obese or Overweight Healthy Volunteers
Alnylam Pharmaceuticals144 enrolled20 locationsNCT06845202
Recruiting
Phase 1
A Study to Evaluate the Effect of Fasting Duration and Tirzepatide Withholding on the Amount of Food and Fluid in the Stomach in Participants With Type 2 Diabetes Mellitus and Participants With Overweight or Obesity Without Type 2 Diabetes Mellitus
ObesityDiabetes Mellitus, Type 2Overweight
Eli Lilly and Company40 enrolled1 locationNCT07299084
Recruiting
Phase 1
A Study of Brenipatide (LY3537031) in Healthy Participants With Overweight or Obesity
ObesityOverweight
Eli Lilly and Company150 enrolled3 locationsNCT07476118
Recruiting
Phase 1
A Study of Multiple Doses of Orally Administered RO7795081 in Otherwise Healthy Chinese Adult Participants With Obesity or Overweight
Healthy VolunteersOverweight or Obesity
Hoffmann-La Roche30 enrolled2 locationsNCT07499050
Recruiting
Phase 1
A Study Looking at How Weekly Injections of Two Hormones - GIP and Amylin - Affect Stomach-related Side Effects in People Who Are Overweight or Obese
OverweightObese
Novo Nordisk A/S100 enrolled1 locationNCT07411560
Recruiting
Phase 1
A Study of IBI3032 in Chinese Healthy Participants and Participants With Overweight or Obesity
Part A: Healthy Part B: Overweight or Obesity
Innovent Biologics Technology Limited (Shanghai R&D Center)104 enrolled1 locationNCT07160400
Recruiting
Phase 1
Human Models of Selective Insulin Resistance: Alpelisib, Part I
Insulin ResistanceNon-Alcoholic Fatty Liver DiseaseOverweight and Obesity+1 more
Columbia University32 enrolled1 locationNCT06354088
Recruiting
Phase 1
The Safety, Tolerability, and Pharmacokinetics of of SYH9017 in Chinese Participants With Overweight and Obesity
Overweight or Obesity
CSPC Baike (Shandong) Biopharmaceutical Co., Ltd.66 enrolled1 locationNCT06830343
Recruiting
Phase 1
A Study Investigating the Safety of RO7795081 and the Effect of RO7795081 on How the Body Processes Pitavastatin and Rosuvastatin in Otherwise Healthy Overweight or Obese Adult Participants
ObesityOverweight
Hoffmann-La Roche40 enrolled1 locationNCT06982131
Recruiting
Phase 1
A Study in People With Overweight or Obesity to Compare How 2 Different Formulations of Survodutide Are Taken up by the Body
ObesityHealthyOverweight
Boehringer Ingelheim80 enrolled1 locationNCT07407348
Recruiting
Phase 1
Understanding the Health Effect of a Bioactive Peptide From Egg: A Pilot Study
High Blood SugarOverweight and ObesityHigh Blood Pressure
University of Alberta28 enrolled1 locationNCT06555393
Recruiting
Phase 1
A Study to Evaluate the Effect of RO7204239 on Insulin Sensitivity and Muscle Composition in Participants With Type 2 Diabetes Mellitus (T2DM) and Overweight or Obesity
ObesityOverweightType 2 Diabetes Mellitus
Hoffmann-La Roche30 enrolled1 locationNCT07137585
Recruiting
Phase 1
A Study of LY4167586 in Participants With Obesity or Overweight Who Are Otherwise Healthy
ObesityOverweight
Eli Lilly and Company84 enrolled2 locationsNCT07225556
Recruiting
Phase 1
A Clinical Study of Semaglutide Nasal Spray in Overweight or Obese Adults
ObesityOverweight
Shanghai World Leader Pharmaceutical Co., Ltd.60 enrolled1 locationNCT07465965