Reflux Clinical Trials

78 recruitingLast updated: June 17, 2026

There are 78 actively recruiting reflux clinical trials across 36 countries. Studies span Not Applicable, Phase 4, Phase 3, Early Phase 1, Phase 2. Top locations include Kansas City, Missouri, United States, Naples, Italy, Milan, Italy. Updated daily from ClinicalTrials.gov.


Reflux Trials at a Glance

78 actively recruiting trials for reflux are listed on ClinicalTrialsFinder across 6 cities in 36 countries. The largest study group is Not Applicable with 34 trials, with the heaviest enrollment activity in Kansas City, Naples, and Milan. Lead sponsors running reflux studies include Mayo Clinic, IRCCS San Raffaele, and Federal State Budgetary Scientific Institution "Federal Research Centre of Nutrition, Biotechnology.

Browse reflux trials by phase

Treatments under study

About Reflux Clinical Trials

Looking for clinical trials for Reflux? There are currently 4 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Reflux trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Reflux clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 78 trials

Recruiting
Phase 4

The Bioavailability and Effect on Pouch pH of Esomeprazole After Gastric Bypass

ObesityGastric refluxUlcer, Gastric
Prof Urs Zingg50 enrolled1 locationNCT05320796
Recruiting
Not Applicable

High Resolution Manometry After Partial Fundoplication for Gastro-oesophageal Reflux

Gastroesophageal RefluxEsophageal Motility DisordersUpper Gastrointestinal Disorder
Prof Urs Zingg100 enrolled1 locationNCT05132816
Recruiting
Phase 4

Famotidine and Antacids for Treatment of Dyspepsia

DyspepsiaGERDAcid Reflux
Stony Brook University80 enrolled1 locationNCT06241183
Recruiting
Phase 3

A Study Comparing the Effect and Safety of Linaprazan Glurate to Lansoprazole in Participants With Erosive Esophagitis (EE) Due to Gastroesophageal Reflux Disease (GERD)

GERD (Gastroesophageal Reflux Disease)
Cinclus Pharma Holding AB500 enrolled75 locationsNCT07037875
Recruiting
Early Phase 1

Development of a Preparation for Supportive Supplementation of Probiotics in Patients With Reflux

MicrobiomeReflux DiseaseProbiotics Supplement
University Hospital Olomouc50 enrolled1 locationNCT07600008
Recruiting
Not Applicable

Deprescribing Inappropriate Proton Pump Inhibitors

inappropriate prescribingProton Pump InhibitorsReflux Disease
University of Bern400 enrolled2 locationsNCT06129474
Recruiting

Study on Hydrotalcite for Relief of Acid Symptoms Due to Acid Rebound After Stopping Long-Term PPI Therapy

Gastroesophageal Reflux
Bayer167 enrolled2 locationsNCT07291700
Recruiting
Not Applicable

Study on the Efficacy and Tolerance of a New Anti-regurgitation Infant Formula (STELLAR)

Gastroesophageal Reflux in Children
United Pharmaceuticals346 enrolled12 locationsNCT04358146
Recruiting

Esophageal and Gastric Registry and Biorepository

Gastro Esophageal Reflux
University of Louisville40 enrolled1 locationNCT05180253
Recruiting

Endoscopic Bariatric Therapies (EBTs): A Retrospective and Prospective Multicenter Registry

ObesityWeight LossGastro Esophageal Reflux+1 more
Weill Medical College of Cornell University9,999 enrolled1 locationNCT04494048
Recruiting
Not Applicable

Safety and Effectiveness of eGERD Device to Reduce Gastroesophageal Reflux Disease (GERD) Symptoms

GERD (Gastroesophageal Reflux Disease)
Gerd Care Medical Ltd84 enrolled4 locationsNCT06613438
Recruiting

Study of Gut Microbiota Diversity in Children Aged 1-3 Years on Prolonged Antibiotic Prophylaxis for Grade 3 or Higher Vesicoureteral Reflux Compared With 2 Age-matched Control Groups

Vesicoureteral Reflux 3
Centre Hospitalier Universitaire de Nīmes150 enrolled2 locationsNCT05319067
Recruiting
Phase 3

Domperidone in Treating Patients With Gastrointestinal Disorders

Nausea and VomitingGastroparesisDyspepsia+4 more
M.D. Anderson Cancer Center200 enrolled1 locationNCT01696734
Recruiting

Esophageal Cancer Risk Registry

Esophageal CancerEsophageal DiseasesEsophageal Achalasia+2 more
University of Pittsburgh7,000 enrolled1 locationNCT00260585
Recruiting
Not Applicable

Mechanistic and Clinical Outcomes of a Surgical Innovation Aimed at Minimizing GERD Associated With VSG (INNOVATE-VSG)

ObesityBariatric SurgeryGastroesophageal Reflux Disease+1 more
University of California, Irvine44 enrolled2 locationsNCT06783751
Recruiting
Not Applicable

Performance and Safety of Afluxin® in Patients With Gastroesophageal Reflux Disease

Gastroesophageal Reflux Disease (GERD)
Devintec Sagl208 enrolled7 locationsNCT06984484
Recruiting
Not Applicable

Validation of the C-mo System - Cough Monitoring

AsthmaChronic Obstructive Pulmonary DiseaseIdiopathic Pulmonary Fibrosis+5 more
Cough Monitoring Medical Solutions300 enrolled8 locationsNCT05989698
Recruiting
Not Applicable

Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty Versus Esophagogastric Anastomosis for Gastric Cancer

Gastric CancerProximal Gastric AdenocarcinomaGastroesophageal Reflux Disease
Nanchong Central Hospital60 enrolled1 locationNCT05514769
Recruiting
Not Applicable

Evaluating Medication Adherence of Patients With Gastroesophageal Reflux Disease With Support of the Smartphone Application GERDCare

GERD (Gastroesophageal Reflux Disease)
Institute of Gastroenterology and Hepatology, Vietnam380 enrolled1 locationNCT07125521
Recruiting
Not Applicable

Compassionate Use of Domperidone for Refractory Gastroparesis

GastroparesisGastroesophageal RefluxGERD
Jose Cocjin20 enrolled1 locationNCT04699591