Refractive Error Clinical Trials

19 recruitingLast updated: May 13, 2026

There are 19 actively recruiting refractive error clinical trials across 12 countries. Studies span Not Applicable. Top locations include Shanghai, Shanghai Municipality, China, Cleveland, Ohio, United States, Chennai, Tamil Nadu, India. Updated daily from ClinicalTrials.gov.


Refractive Error Trials at a Glance

19 actively recruiting trials for refractive error are listed on ClinicalTrialsFinder across 6 cities in 12 countries. The largest study group is Not Applicable with 14 trials, with the heaviest enrollment activity in Shanghai, Cleveland, and Chennai. Lead sponsors running refractive error studies include Essilor International, Queen's University, Belfast, and Shanghai Eye Disease Prevention and Treatment Center.

Browse refractive error trials by phase

Treatments under study

About Refractive Error Clinical Trials

Looking for clinical trials for Refractive Error? There are currently 3 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Refractive Error trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Refractive Error clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 119 of 19 trials

Recruiting

To Study the Effects of Refractive Surgery on OCT Measurements in the Eye

MyopiaOptical Coherence TomographyRefractive errors
University of Nebraska33 enrolled1 locationNCT05856786
Recruiting
Not Applicable

Cognitive Level Enhancement Through Vision Exams and Refraction

Refractive errors
Queen's University, Belfast820 enrolled1 locationNCT05458323
Recruiting

Morphological Characteristics of the Maxillomandibular Region in a 3D Representation and the Refractive Status of the Eye

Refractive errors
University of Zagreb120 enrolled1 locationNCT07460557
Recruiting
Not Applicable

An Evaluation of Myopia Control Lenses on Wearing Experience in Myopic Children

Refractive ErrorMyopia
Essilor International40 enrolled1 locationNCT07354945
Recruiting

Clinical Data Collection of Myopic Patients After PTK-PRK With CZM MEL 90 Excimer Laser

Refractive errors
London Vision Clinic150 enrolled2 locationsNCT06996353
Recruiting

Corneal Elastography and Patient Specific Modeling

KeratoconusCornea; EctasiaRefractive errors
The Cleveland Clinic60 enrolled1 locationNCT03030755
Recruiting
Not Applicable

Post Marketing Clinical Study on the Efficacy of Lenses From a New Prescription Protocol

Refractive ErrorAmetropia
Essilor International120 enrolled1 locationNCT07168564
Recruiting
Not Applicable

Optimizing Light Exposure for Myopia Prevention and Control (LightSPAN)

MyopiaMyopia; Refractive ErrorMyopia Progression+2 more
National University of Singapore396 enrolled5 locationsNCT06631339
Recruiting
Not Applicable

Measuring Changes In Choroidal Thickness Induced By Prototype Soft Contact Lenses Worn For 1 Hour

Myopia; Refractive Error
Myoptechs, Inc20 enrolled1 locationNCT07155551
Recruiting
Not Applicable

Algorithm-assisted Subjective Refraction Program Dedicated to Children

AstigmatismChildrenRefractive Disorders+3 more
Essilor International166 enrolled1 locationNCT07046065
Recruiting
Not Applicable

Clinical Study of SMILE 4.0-VISULYZE in Correcting Refractive Errors

Myopia; Refractive ErrorRefractive Surgery
Affiliated Hospital of Nantong University600 enrolled2 locationsNCT06982807
Recruiting
Not Applicable

The Objective of This Study is to Evaluate the Perfomance of a Photorefraction Device for Screening Ametropia in Children. Eligible Participants Will Undergo Multiple Refractive Error Measurements, Visual Acuity and Strabismus Assessments During a Single Evaluation Visit.

AmetropiaMyopia; Refractive ErrorMyopia; Astigmatism
Essilor International315 enrolled2 locationsNCT06882408
Recruiting
Not Applicable

Correcting Myopia Among Secondary School Children to Increase Academic High School Attendance Rates in Rural Communities

Refractive errors
Queen's University, Belfast10,000 enrolled3 locationsNCT04077086
Recruiting
Not Applicable

Minimum Power and Frequency of Repeated Low-level Red-light to Effectively Control Myopia Progression

MyopiaChoroidal thicknessRefractive Error - Myopia+1 more
Shanghai Eye Disease Prevention and Treatment Center108 enrolled1 locationNCT06717048
Recruiting
Not Applicable

Evaluate the Safety and Effectiveness of the AccuraSee™ IOPCL for Secondary Implantation in the Capsular Bag to Improve Near and/or Intermediate Vision Following Previous Cataract Surgery

Refractive SurgeryRefractive Error - Myopia
OnPoint Vision Inc10 enrolled1 locationNCT06625749
Recruiting
Not Applicable

Clinical Investigation for a Multifunction Ophthalmic Measurement Device

Dry EyeKeratoconusAccommodation Disorder+4 more
Essilor International378 enrolled1 locationNCT06565091
Recruiting
Not Applicable

Effect of Colour Temperature of Reading Lamp on Refractive Error Development

Refractive errors
The Hong Kong Polytechnic University798 enrolled1 locationNCT05733182
Recruiting
Not Applicable

Shanghai Eye Study for Adults

Blindness,Visual Impairment, Refractive Error, Cataract, High Myopia, Aging
Shanghai Eye Disease Prevention and Treatment Center1,000,000 enrolled1 locationNCT03455478
Recruiting

Using eye movements to measure vision in children

AnisometropiaStrabismusAmblyopia+1 more
University of Auckland120 enrolled2 locationsACTRN12617000338369