Phase 3 Replacement Clinical Trials
21 recruitingPhase 3
What is a Phase 3 trial?
Phase 3 trials compare the new treatment against the current standard of care in large groups, often hundreds to thousands of participants. Successful Phase 3 results are typically required for regulatory approval.
Showing 1–20 of 21 trials
Recruiting
Phase 3
Suzetrigine for Treatment and Reduction of Intense Discomfort After knEe Replacement PAIN
Total knee replacement surgeryPost Operative Pain
Icahn School of Medicine at Mount Sinai235 enrolled1 locationNCT07548385
Recruiting
Phase 3
Safety Evaluation of Prismocitrate 18 in Patients Receiving CRRT
Acute Kidney Injury (AKI)Regional Citrate Anticoagulation (RCA)Continuous Renal Replacement Therapy (CRRT)
Vantive Health LLC40 enrolled14 locationsNCT05399537
Recruiting
Phase 3
Suzetrigine in Total Hip Arthroplasty
Total Hip Replacement SurgeryPainPain Management+13 more
Hospital for Special Surgery, New York210 enrolled1 locationNCT07226700
Recruiting
Phase 3
Low INR to Minimize Bleeding With Mechanical Valves Trial
Bleeding Post-mechanical Valve ReplacementThromboembolism Post-mechanical Valve Replacement
Population Health Research Institute2,625 enrolled35 locationsNCT03636295
Recruiting
Phase 3
Post-Operative Urinary Retention on Revision Knee Arthroplasty: the Role of Intrathecal Morphine
Nerve BlockAnesthesia, SpinalArthroplasties, Knee Replacement+1 more
University of Toronto50 enrolled1 locationNCT07050277
Recruiting
Phase 2Phase 3
Antibiotic Impregnated Bone Graft to Reduce Infection in Hip Replacement.
Antibiotic Resistant InfectionOsteoarthritis, HipProsthetic joint infection+1 more
University Hospital, Linkoeping1,100 enrolled1 locationNCT05169229
Recruiting
Phase 3
Short Versus Long Antiplatelet Therapy After TAVI
Transcatheter Aortic Valve Replacement
University Hospital, Caen1,400 enrolled1 locationNCT06518317
Recruiting
Phase 2Phase 3
Low-intensity Versus Medium-intensity Continuous Kidney Replacement Therapy for Critically Ill Patients
Acute Kidney Injury Requiring Continuous Renal Replacement Therapy
Jikei University School of Medicine400 enrolled9 locationsNCT06014801
Not Yet Recruiting
Phase 2Phase 3
Dexmedetomidine as an adjuvant to levobupivacaine for spinal anaesthesia in elderly patients undergoing hip replacement surgery: Prospective, randomised, double-blinded study.
hip replacement surgery
University Hospital Centre Sestre Milosrdnice60 enrolled1 locationACTRN12623000153617
Active
Phase 3
Comparative effect of resuscitation with hypertonic saline versus normal saline after extracorporeal circulation during cardiovascular surgery in the Intensive Care Unit (ICU)
Crystalloid resuscitation after valve replacement surgery and coronary artery bypass surgery that underwent extracorporeal circulation
Ray Mendoza Franco102 enrolled1 locationACTRN12615000466549
Recruiting
Phase 3
Dexmeditomedine for mitral valve replacement
patients with tight mitral stenosis scheduled for mitral valve replacement
south valley university -Qena university hospital70 enrolled1 locationACTRN12613000495729
Not Yet Recruiting
Phase 3
Vitamin D status in heart surgery patients and effects on clinical outcomes
Elective cardiac surgery patients requiring either or both coronary artery bypass graft or valve repair or replacement
The Alfred100 enrolled1 locationACTRN12611000516987
Not Yet Recruiting
Phase 3
Study for the assessment of clinical non-inferiority and tolerability of Estrogenon (Sanval Comercio e Industria Ltda) in comparasion to Premarin (Wyeth Industria Farmaceutica Ltda) in women post menopause.
Study with the purpose of check clinical non- inferiority and tolerance of conjugated estrogen coated tablet manufactured by different manufacturesWomen in post menopause with indications for estrogens replacement therapy.
Sanval Comercio e Industria Ltda66 enrolled1 locationACTRN12610000119099
Not Yet Recruiting
Phase 3
Study for the assessment of clinical non-inferiority and tolerability of different conjugated estrogen vaginal cream ESTROGENON (Sanval Comercio e Industria Ltda) versus PREMARIN (Wyeth Industria Farmaceutica Ltda) in women post menopause.
Women in post menopause with indications for estrogen replacement therapy.Study with the purpose of check clinical non-inferiority and tolerance of two vaginal cream based on the conjugated estrogen manufactured by different manufacturers.
Sanval Comercio e Industria Ltda.66 enrolled1 locationACTRN12610000103066
Recruiting
Phase 3Phase 4
A prospective randomised trial to study the effect of intravenous iron infusion versus oral iron therapy in pre-operative anaemia
Pre-operative anaemia in elective surgery patients e.g. in orthoplasty (hip- and Knee replacement) and gynaecological elective surgery etc...
Clifford Craig Medical Research Trust120 enrolled1 locationACTRN12609000596202
Active
Phase 3
SNUG-2: Studying Neurons Using Glypromate® - Second Study
Cardiopulmonary bypass (CPB) procedures for coronary bypass grafting (CABG) and/or valve replacement/repair due to the significant incidence of neurocognitive changes following such surgery
Neuren Pharmaceuticals Ltd355 enrolled2 locationsACTRN12608000168358
Not Yet Recruiting
Phase 3
Prospective trial of selective ultrasound-guided obturator nerve blockade for total knee replacement.
Patients undergoing unilateral total knee replacement.
Timothy Lee40 enrolled1 locationACTRN12607000640404
Not Yet Recruiting
Phase 3
A study to assess the safety and efficacy of Navigator in post operative cardiac surgery patients versus conventional care.
Elective cardiac bypass grafting and / or heart valve repair or replacement whilst utilising heart lung perfusion pump.
Applied Physiology Pty Limited100 enrolled1 locationACTRN12607000085471
Completed
Phase 3
REgulation of Coagulation in ORthopedic Surgery to prevent DVT and PE, controlled, double-blind, randomized study of BAY 59-7939 in the extended prevention of VTE in patients undergoing elective total hip replacement.
Patients undergoing total hip replacement.
Bayer Australia Limited2,500 enrolled1 locationACTRN12606000069550
Completed
Phase 3
REgulation of Coagulation in ORthopedic Surgery to prevent DVT and PE, controlled, double-blind, randomized study of BAY 59-7939 in the extended prevention of VTE in patients undergoing elective total hip replacement.
Patients undergoing total hip replacement.
Bayer Australia Limited4,200 enrolled1 locationACTRN12606000068561