Respiratory distress Clinical Trials

201 recruitingLast updated: June 18, 2026

There are 201 actively recruiting respiratory distress clinical trials across 55 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 4, Phase 1, Early Phase 1. Top locations include Houston, Texas, United States, New York, New York, United States, Cleveland, Ohio, United States. Updated daily from ClinicalTrials.gov.


Respiratory distress Trials at a Glance

201 actively recruiting trials for respiratory distress are listed on ClinicalTrialsFinder across 6 cities in 55 countries. The largest study group is Not Applicable with 76 trials, with the heaviest enrollment activity in Houston, New York, and Cleveland. Lead sponsors running respiratory distress studies include Southeast University, China, Assistance Publique - Hôpitaux de Paris, and PPD Development, LP.

Browse respiratory distress trials by phase

Treatments under study

About Respiratory distress Clinical Trials

Looking for clinical trials for Respiratory distress? There are currently 9 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Respiratory distress trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Respiratory distress clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 201 trials

Recruiting
Phase 2

Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)

InfectionsAcute Respiratory Distress Syndrome
BioAegis Therapeutics Inc.600 enrolled70 locationsNCT05947955
Recruiting
Early Phase 1

A Single Dose, Dose Escalation Clinical Trial on the Safety, Tolerability and Efficacy of Lyophilized Powder for Inhalation of Recombinant Human Keratinocyte Growth Factor-2 (Rh-KGF-2) in The Treatment of Patients With Acute Respiratory Distress Syndrome

ARDS (Moderate or Severe)ARDS (Acute Respiratory Distress Syndrome)
Shanghai Zhongshan Hospital24 enrolled1 locationNCT07558538
Recruiting

Lung Injury is One of the Primary Causes of Morbidity and Mortality in Critically Ill Patients. These Patients Will be Monitored for: 1) Immune Cell Activation 2) Blood-based Biomarkers. In Vitro Models Derived From These Samples Will be Treated With Novel Agent PIP-2 to Evaluate Its Efficacy.

ARDS (Acute Respiratory Distress Syndrome)
University of Pennsylvania36 enrolled1 locationNCT07125079
Recruiting
Phase 1Phase 2

Study on Safety and Efficacy of Two Doses of PRS CK STORM in the Modulation of the Cytokine Storm in Patients With Acute Respiratory Infection Caused by SARS-Cov-2, Influenza A, Influenza B and Respiratory Syncytial Virus (RSV)

Systemic Inflammatory Response SyndromeSARS CoV-2Respiratory distress syndrome+2 more
PEACHES BIOTECH50 enrolled3 locationsNCT06684379
Recruiting
Phase 2Phase 3

Volatile Sedation for Patients With the Acute Respiratory Distress Syndrome

Mechanical Ventilation ComplicationAcute Respiratory Distress SyndromeSedation Complication
Guy's and St Thomas' NHS Foundation Trust20 enrolled1 locationNCT06014138
Recruiting
Phase 1

Pharmacokinetics and Placental Transfer of Caffeine

Apnea of PrematurityPremature BirthBronchopulmonary Dysplasia+2 more
Indiana University30 enrolled1 locationNCT07570121
Recruiting

Altitude and Outcomes in Pediatric ARDS: A Multicenter Study

High Altitude EffectsAltitude HypoxiaRespiratory Distress Syndrome, Pediatric
Latin American Pediatric Collaborative Network1,600 enrolled20 locationsNCT07193771
Recruiting
Not Applicable

Titration of Positive End-expiratory Pressure: Comparison Between Manual Thoracic or Abdominal Compression and Electrical Impedance Tomography

ARDS (Acute Respiratory Distress Syndrome)
Centre Hospitalier Saint Joseph Saint Luc de Lyon30 enrolled2 locationsNCT07623590
Recruiting

Pulmonary Overdistension Assessment With Electrical Impedance Tomography in Patients With Acute Respiratory Distress Syndrom in Prone Position.

Acute Respiratory Distress Syndrome (ARDS)
Centre Hospitalier de la côte Basque30 enrolled1 locationNCT07090460
Recruiting
Not Applicable

Surfactant Therapy Via Supraglottic Airway to Preterm Neonates With RDS in Vietnam

Respiratory Distress Syndrome in Premature Infant
Karolinska Institutet440 enrolled1 locationNCT07098910
Recruiting
Not Applicable

30% or 60% Oxygen at Birth to Improve Neurodevelopmental Outcomes in Very Low Birthweight Infants

Premature InfantRespiratory Distress Syndrome in Premature InfantNeurodevelopmental Outcome
University of Alberta1,200 enrolled21 locationsNCT03825835
Recruiting
Phase 2

Corticosteroids in Hyperinflammatory Phenotype of Critical Illness

SepsisAcute Respiratory Distress Syndrome
Bin Du150 enrolled1 locationNCT07511582
Recruiting
Phase 1

Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HT31-1 for Treating ARDS

ARDS (Acute Respiratory Distress Syndrome)
HTIC, Inc24 enrolled2 locationsNCT07449572
Recruiting

Predictive Value of Lung Ultrasound for Respiratory Decompensation in Late Preterm Neonates

Pre-TermPrematureRespiratory Distress of Newborn
Hackensack Meridian Health300 enrolled1 locationNCT07216053
Recruiting
Not Applicable

Effect of EIT-guided PEEP in ARDS Patients

ARDS (Acute Respiratory Distress Syndrome)
Southeast University, China2,400 enrolled3 locationsNCT06990477
Recruiting
Not Applicable

Optimising Breathing Support at Extubation in Very Preterm Infants: A Clinical Study

Respiratory Distress Syndrome in Premature InfantRespiratory Distress Syndrome, Newborn
Murdoch Childrens Research Institute134 enrolled2 locationsNCT07251790
Recruiting
Not Applicable

Amnioinfusion's Protective Effects on Respiratory and Longitudinal Pediatric Outcomes After Intrapartum Thick Meconium Exposure

Neonatal Brain Injuryperinatal morbidityMechanical Ventilation+10 more
Medical College of Wisconsin320 enrolled1 locationNCT07274527
Recruiting
Not Applicable

Effect of Continuous Prolonged Prone Position Versus Intermittent Daily Prone Position in ARDS

Acute Respiratory Distress Syndrome
Pontificia Universidad Catolica de Chile780 enrolled38 locationsNCT06854627
Recruiting

Study of the Immunological Pathophysiological Mechanisms Associated With Acute Respiratory Distress Syndrome

Acute Respiratory Distress Syndrome (ARDS)
Assistance Publique - Hôpitaux de Paris50 enrolled1 locationNCT07395076
Recruiting
Phase 3

Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome

Respiratory FailureAcute Respiratory Distress Syndrome
Beth Israel Deaconess Medical Center1,100 enrolled33 locationsNCT06066502