seizure Clinical Trials

80 recruitingLast updated: May 21, 2026

There are 80 actively recruiting seizure clinical trials across 37 countries. Studies span Not Applicable, Phase 2, Phase 3, Early Phase 1, Phase 1, Phase 4. Top locations include Madrid, Spain, Phoenix, Arizona, United States, Bethesda, Maryland, United States. Updated daily from ClinicalTrials.gov.


seizure Trials at a Glance

80 actively recruiting trials for seizure are listed on ClinicalTrialsFinder across 6 cities in 37 countries. The largest study group is Not Applicable with 22 trials, with the heaviest enrollment activity in Madrid, Phoenix, and Bethesda. Lead sponsors running seizure studies include Mayo Clinic, Supernus Pharmaceuticals, Inc., and Children's Hospital of Fudan University.

About seizure Clinical Trials

Looking for clinical trials for seizure? There are currently 8 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new seizure trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about seizure clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 80 trials

Recruiting
Phase 3

A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures

Primary Generalized Tonic-Clonic Seizures
Xenon Pharmaceuticals Inc.160 enrolled138 locationsNCT05667142
Recruiting
Phase 3

Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1

EpilepsyFocal EpilepsyFocal Seizure
Rapport Therapeutics Inc.333 enrolled1 locationNCT07563881
Recruiting
Phase 3

A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)

Focal Onset Seizures
Xenon Pharmaceuticals Inc.360 enrolled95 locationsNCT05716100
Recruiting
Phase 1

A Study to Evaluate the Efficacy and Safety of Cannabidiol Oral Solution (CBD-OS [GWP42003-P, JZP926]) for the Treatment of Focal-Onset Seizures

Focal Seizures
Jazz Pharmaceuticals100 enrolled24 locationsNCT07233239
Recruiting
Not Applicable

AI-Based Mobile Intervention on Medication Non-Adherence and Transition

seizureEpilepsy
University of Central Florida200 enrolled2 locationsNCT07445074
Recruiting
Phase 3

A Study to Test the Efficacy and Safety of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures

Stereotypical Prolonged Seizures
UCB Biopharma SRL350 enrolled183 locationsNCT05077904
Recruiting
Phase 2

Safety and Tolerability Study of SPN-817 in Adult Patients With Treatment Resistant Epilepsy

EpilepsySeizures, Epileptic
Supernus Pharmaceuticals, Inc.60 enrolled10 locationsNCT05518578
Recruiting
Not Applicable

A Pilot Study to Evaluate the Efficacy and Safety of NaviFUS™ System Neuromodulating Treatment for Patients With Drug Resistant Epilepsy

EpilepsyDrug Resistant EpilepsyEpilepsy, Temporal Lobe+1 more
NaviFUS Corporation16 enrolled1 locationNCT06492720
Recruiting
Phase 1Phase 2

A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patients With Drug-resistant Epilepsy

seizureEpilepsyDrug Resistant Epilepsy+2 more
NaviFUS Corporation8 enrolled3 locationsNCT06388707
Recruiting

Investigating Epilepsy: Screening and Evaluation

EpilepsySeizuresEpilepsy, Temporal Lobe+1 more
National Institute of Neurological Disorders and Stroke (NINDS)1,000 enrolled1 locationNCT03478852
Recruiting
Not Applicable

Thalamus Seizure Detection With a Deep Brain Stimulator System

Epilepsy; Seizure
Mayo Clinic5 enrolled1 locationNCT06700356
Recruiting
Not Applicable

Optimizing Therapy in Epilepsy Using Seizure Forecasts Via EEG and Wearables

Focal EpilepsyGeneralized SeizureDrug Refractory Epilepsy
Mayo Clinic12 enrolled1 locationNCT07012148
Recruiting
Phase 2

Prophylactic Anti-Seizure Medication vs No Anti-Seizure Medication for Patients With Primary Motor Cortex Brain Metastases

Brain Metastases, AdultBrain Metastases From Non-small Cell Lung Cancer (NSCLC)Brain Metastases From Extra-cranial Solid Tumors+2 more
Ayal A. Aizer, MD150 enrolled1 locationNCT07130786
Recruiting
Not Applicable

A Multi-site Feasibility Clinical Trial of Retraining and Control Therapy (ReACT), a Mind and Body Treatment for Pediatric Functional Seizures

Convulsion, Non-EpilepticFunctional Seizures
University of Alabama at Birmingham108 enrolled1 locationNCT05819268
Recruiting

Etiology and Treatment of Neonatal Seizure

SeizuresSeizure DisorderSeizure Newborn+1 more
Children's Hospital of Fudan University2,000 enrolled1 locationNCT03822741
Recruiting
Not Applicable

Cognitive Rehabilitation for Veterans With PNES

Psychogenic Nonepileptic Seizures (PNES)
VA Office of Research and Development47 enrolled1 locationNCT07316543
Recruiting
Not Applicable

Multimodal Clinical Study of Electroconvulsive Therapy and Magnetic Seizure Therapy

Major Depressive DisorderElectroconvulsive TherapyMagnetic Seizure Therapy
The Second Hospital of Anhui Medical University200 enrolled1 locationNCT07473648
Recruiting

Late-Onset Seizures: Trial of Vascular Risk Investigation and Treatment

seizureEpilepsy
Sahlgrenska University Hospital420 enrolled3 locationsNCT07116330
Recruiting
Phase 3

Short Versus Long-term Levetiracetam in Brain Tumors

SeizuresBrain TumorsAntiepileptics+1 more
Tata Memorial Centre604 enrolled2 locationsNCT06442748
Recruiting
Phase 2

A Long-term Study of the Safety and Effectiveness of RAP-219 in Adults With Focal Onset Seizures

seizureEpilepsyRefractory Focal Epilepsy+3 more
Rapport Therapeutics Inc.30 enrolled7 locationsNCT07219407