Focal Epilepsy Clinical Trials

22 recruitingLast updated: May 21, 2026

There are 22 actively recruiting focal epilepsy clinical trials across 28 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 4. Top locations include Houston, Texas, United States, Rochester, Minnesota, United States, New York, New York, United States. Updated daily from ClinicalTrials.gov.


Focal Epilepsy Trials at a Glance

22 actively recruiting trials for focal epilepsy are listed on ClinicalTrialsFinder across 6 cities in 28 countries. The largest study group is Not Applicable with 10 trials, with the heaviest enrollment activity in Houston, Rochester, and New York. Lead sponsors running focal epilepsy studies include Biohaven Therapeutics Ltd., Mayo Clinic, and Rapport Therapeutics Inc..

Browse focal epilepsy trials by phase

About Focal Epilepsy Clinical Trials

Looking for clinical trials for Focal Epilepsy? There are currently 19 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Focal Epilepsy trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Focal Epilepsy clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 22 trials

Recruiting
Phase 3

Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1

EpilepsyFocal EpilepsyFocal Seizure
Rapport Therapeutics Inc.333 enrolled1 locationNCT07563881
Recruiting
Not Applicable

Spatial Scene Recognition Memory in Epilepsy Surgery

Medically refractory epilepsyMemory deficitsMemory Disorders+9 more
University of California, Davis620 enrolled2 locationsNCT07580183
Recruiting
Phase 2Phase 3

A Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy

Focal Epilepsy
Biohaven Therapeutics Ltd.390 enrolled124 locationsNCT06132893
Recruiting
Phase 2Phase 3

Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy

Focal Epilepsy
Biohaven Therapeutics Ltd.390 enrolled174 locationsNCT06309966
Recruiting
Phase 3

Double-blind, Randomized Clinical Trial Evaluating the Efficacy and Safety of Vormatrigine in Adults With Focal Seizures

Focal Epilepsy
Praxis Precision Medicines300 enrolled7 locationsNCT07505004
Recruiting
Not Applicable

Optimizing Therapy in Epilepsy Using Seizure Forecasts Via EEG and Wearables

Focal EpilepsyGeneralized SeizureDrug Refractory Epilepsy
Mayo Clinic12 enrolled1 locationNCT07012148
Recruiting
Not Applicable

Psychological and Psychiatric Assessment in Patients Eligible for Epilepsy Surgery

Focal Epilepsy With and Without Secondary Generalization
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta180 enrolled1 locationNCT06792383
Recruiting
Not Applicable

Thalamic Recordings in Children Undergoing SEEG

Focal Epilepsy
Great Ormond Street Hospital for Children NHS Foundation Trust30 enrolled1 locationNCT06453759
Recruiting
Not Applicable

Study of Transcranial Direct Current Stimulation to Treat Epilepsy

Focal EpilepsyGeneralized Onset EpilepsySleep-related Epileptic Encephalopathy
Mayo Clinic30 enrolled1 locationNCT05673915
Recruiting
Phase 2

A Long-term Study of the Safety and Effectiveness of RAP-219 in Adults With Focal Onset Seizures

seizureEpilepsyRefractory Focal Epilepsy+3 more
Rapport Therapeutics Inc.30 enrolled7 locationsNCT07219407
Recruiting
Not Applicable

Evaluation of New Flexible High-density Intra-operative ECoG Electrodes for Epilepsy Surgery. ( EpiGrid )

Focal EpilepsyIntraoperative Monitoring
Neurosoft Bioelectronics SA12 enrolled1 locationNCT06205160
Recruiting
Phase 2

An Open-label Study to Evaluate Safety, Tolerability, and Efficacy of CB03-154 in Subjects Diagnosed With Epilepsy

Focal Epilepsy
Shanghai Zhimeng Biopharma, Inc.144 enrolled1 locationNCT07238868
Recruiting
Phase 4

Butylphthalide for Cognitive Impairment in Elderly Patients With Focal Epilepsy

Cognitive ImpairmentFocal Epilepsy
First Affiliated Hospital of Wenzhou Medical University220 enrolled1 locationNCT07193277
Recruiting

Real-world Clinical Response to Cenobamate Early add-on in France, Germany and Spain

Focal Epilepsy With and Without Secondary Generalization
Aziende Chimiche Riunite Angelini Francesco S.p.A300 enrolled1 locationNCT06716801
Recruiting
Not Applicable

Multi-level Approach of Brain Activity Using Intracranial Electrodes in Epileptic Patients

Cognitive FunctionFocal EpilepsyElectrodes, Implanted+1 more
Institut National de la Santé Et de la Recherche Médicale, France50 enrolled1 locationNCT04653012
Recruiting
Not Applicable

Sleep Architecture & Cognition in Focal Epilepsy

Focal Epilepsy
University of California, Davis40 enrolled1 locationNCT05794295
Recruiting
Not Applicable

Breathing Rescue for SUDEP Prevention

Focal Epilepsy
The University of Texas Health Science Center, Houston100 enrolled1 locationNCT05981755
Recruiting
Not Applicable

Diffusion MRI Methods to Minimize Postoperative Deficits in Pediatric Epilepsy Surgery

Focal Epilepsy
Wayne State University60 enrolled1 locationNCT04986683
Recruiting

Cognitive Impairment in Drug-resistant and Drug-responsive Focal Cryptogenic Epilepsy

EpilepsyFocal Epilepsy
IRCCS San Raffaele130 enrolled1 locationNCT06210022
Recruiting

Optimized Volumetry in Radiology: Interest in Pediatric Brain MRI in the Exploration of Focal Epilepsy

Focal Epilepsy
University Hospital, Tours240 enrolled5 locationsNCT05100771