Phase 1 Soft Tissue Clinical Trials
49 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 49 trials
Recruiting
Phase 1
Novel RNA-lipid Particle (RNA-LP) Vaccine for Anti-PD-1 Antibody Therapy Sensitization
Soft Tissue SarcomaMelanoma
University of Florida18 enrolled1 locationNCT05264974
Recruiting
Phase 1
A Phase I Study of Pazopanib in Combination With Trabectedin, Ipilimumab and Nivolumab (TraPIN) in Pediatric and Young Adult Patients With Recurrent Soft Tissue Sarcomas
Soft Tissue Sarcomas
M.D. Anderson Cancer Center18 enrolled1 locationNCT07444619
Recruiting
Phase 1Phase 2
Trial of Single Protein Encapsulated Doxorubicin, SPEDOX-6 in Advanced Malignancies
Triple-Negative Breast CancerOvarian CancerCervical Cancer+3 more
University of California, Irvine67 enrolled1 locationNCT07064018
Recruiting
Phase 1
Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases
Malignant Neoplasm of Bone and Articular CartilageMalignant Neoplasms of Female Genital OrgansMalignant Neoplasms of Independent (Primary) Multiple Sites+7 more
M.D. Anderson Cancer Center44 enrolled1 locationNCT03093909
Recruiting
Phase 1
Actinium Therapy for Late-stage Aggressive Sarcomas
Advanced Soft Tissue Sarcoma
Ratio Therapeutics, Inc.30 enrolled6 locationsNCT07156565
Recruiting
Phase 1Phase 2
Atezolizumab Plus Tivozanib in Immunologically Cold Tumor Types
Breast CancerOvarian CancerProstate Cancer+6 more
University of Florida29 enrolled1 locationNCT05000294
Recruiting
Phase 1
A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic Solid Tumors
Gastric CancerColon CancerTriple Negative Breast Cancer(TNBC)+8 more
SHY Therapeutics30 enrolled3 locationsNCT07705334
Recruiting
Phase 1
Zanzalintinib in Combination With Ipilimumab and Nivolumab in Patients With Metastatic Soft Tissue Sarcoma
Metastatic Soft Tissue Sarcoma
Washington University School of Medicine18 enrolled1 locationNCT06968988
Recruiting
Phase 1
Phase I Study of JFI447 [68Ga]Ga-DFC413 and Comparison to FFG233 [68Ga]Ga-NNS309 in Patients With Solid Tumors
Non-small Cell Lung Cancer (NSCLC)Triple Negative Breast Cancer(TNBC)Soft Tissue Sarcoma (STS)+4 more
Novartis Pharmaceuticals66 enrolled1 locationNCT07630961
Recruiting
Phase 1Phase 2
Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma
Metastatic Soft Tissue SarcomaMetastatic LeiomyosarcomaAdvanced Soft Tissue Sarcoma+5 more
National Cancer Institute (NCI)74 enrolled1 locationNCT06498648
Recruiting
Phase 1
Phase I Study of [177Lu]Lu-DFC413 in Patients With Solid Tumors
Triple-Negative Breast CancerColorectal, CancerSoft Tissue Sarcoma+3 more
Novartis Pharmaceuticals180 enrolled8 locationsNCT07261631
Recruiting
Phase 1
Tumor Neoantigen Vaccine SarVac Combined With Tumor Specific Lymphocyte Reinfusion in the Treatment of Advanced Sarcoma
OsteosarcomaSoft Tissue Sarcoma (STS)
Sun Yat-sen University16 enrolled1 locationNCT07648069
Recruiting
Phase 1
PET [89Zr]DFO-starPEG in Solid Tumors
Solid TumorSolid CarcinomaSoft Tissue Lesion
Robert Flavell, MD, PhD13 enrolled1 locationNCT06894745
Recruiting
Phase 1Phase 2
The Combination of Radiotherapy, Chemotherapy and Immunotherapy in High-Risk Localized Soft Tissue Sarcoma
High-Risk Localized Soft Tissue Sarcoma
Fudan University52 enrolled1 locationNCT05774275
Recruiting
Phase 1Phase 2
Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma
Recurrent Malignant Solid NeoplasmRefractory Malignant Solid NeoplasmRecurrent Solid Tumor+19 more
St. Jude Children's Research Hospital90 enrolled10 locationsNCT04901702
Recruiting
Phase 1
B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)
Soft Tissue SarcomaMelanomaCarcinoma+13 more
St. Jude Children's Research Hospital48 enrolled1 locationNCT04897321
Recruiting
Phase 1
A Study Evaluating the Safety, Pharmacokinetics and Early Efficacy of AVA6000 in Solid Tumours
Breast CancerUrothelial CarcinomaSoft Tissue Sarcoma+2 more
Avacta Life Sciences Ltd158 enrolled9 locationsNCT04969835
Recruiting
Phase 1
Safety and Efficacy of DIT309 in Advanced Bone and Soft Tissue Sarcomas
Soft Tissue SarcomaOsteosarcoma
Tcelltech Inc.15 enrolled1 locationNCT07052383
Recruiting
Phase 1
A First-In-Human Phase 1 Trial of T-Cell Membrane-Anchored Tumor Targeted Il12 (Attil12)- T-Cell Therapy in Subjects With Advanced/Metastatic Soft Tissue and Bone Sarcoma
Soft Tissue SarcomaBone Sarcoma
M.D. Anderson Cancer Center40 enrolled1 locationNCT05621668
Recruiting
Phase 1Phase 2
Retifanlimab (Anti-PD-1 Antibody) With Gemcitabine and Docetaxel in Patients With Advanced Soft Tissue Sarcoma
Soft Tissue SarcomaSarcomaSarcoma,Soft Tissue+1 more
Memorial Sloan Kettering Cancer Center98 enrolled1 locationNCT04577014