Phase 1 Soft Tissue Clinical Trials
44 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 44 trials
Recruiting
Phase 1Phase 2
Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma
Recurrent Malignant Solid NeoplasmRefractory Malignant Solid NeoplasmRecurrent Solid Tumor+19 more
St. Jude Children's Research Hospital90 enrolled10 locationsNCT04901702
Recruiting
Phase 1
Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases
Malignant Neoplasm of Bone and Articular CartilageMalignant Neoplasms of Female Genital OrgansMalignant Neoplasms of Independent (Primary) Multiple Sites+7 more
M.D. Anderson Cancer Center44 enrolled1 locationNCT03093909
Recruiting
Phase 1
B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)
Soft Tissue SarcomaMelanomaCarcinoma+13 more
St. Jude Children's Research Hospital48 enrolled1 locationNCT04897321
Recruiting
Phase 1
A Study Evaluating the Safety, Pharmacokinetics and Early Efficacy of AVA6000 in Solid Tumours
Breast CancerUrothelial CarcinomaSoft Tissue Sarcoma+2 more
Avacta Life Sciences Ltd158 enrolled9 locationsNCT04969835
Recruiting
Phase 1Phase 2
Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma
Metastatic Soft Tissue SarcomaMetastatic LeiomyosarcomaAdvanced Soft Tissue Sarcoma+5 more
National Cancer Institute (NCI)74 enrolled1 locationNCT06498648
Recruiting
Phase 1
Safety and Efficacy of DIT309 in Advanced Bone and Soft Tissue Sarcomas
Soft Tissue SarcomaOsteosarcoma
Tcelltech Inc.15 enrolled1 locationNCT07052383
Recruiting
Phase 1
A First-In-Human Phase 1 Trial of T-Cell Membrane-Anchored Tumor Targeted Il12 (Attil12)- T-Cell Therapy in Subjects With Advanced/Metastatic Soft Tissue and Bone Sarcoma
Soft Tissue SarcomaBone Sarcoma
M.D. Anderson Cancer Center40 enrolled1 locationNCT05621668
Recruiting
Phase 1
Phase I Study of [177Lu]Lu-DFC413 in Patients With Solid Tumors
Triple-Negative Breast CancerColorectal, CancerSoft Tissue Sarcoma+3 more
Novartis Pharmaceuticals180 enrolled7 locationsNCT07261631
Recruiting
Phase 1
Novel RNA-lipid Particle (RNA-LP) Vaccine for Anti-PD-1 Antibody Therapy Sensitization
Soft Tissue SarcomaMelanoma
University of Florida18 enrolled1 locationNCT05264974
Recruiting
Phase 1Phase 2
Retifanlimab (Anti-PD-1 Antibody) With Gemcitabine and Docetaxel in Patients With Advanced Soft Tissue Sarcoma
Soft Tissue SarcomaSarcomaSarcoma,Soft Tissue+1 more
Memorial Sloan Kettering Cancer Center98 enrolled1 locationNCT04577014
Recruiting
Phase 1Phase 2
Pulmonary Suffusion in Controlling Minimal Residual Disease in Patients With Sarcoma or Colorectal Metastases
Colorectal, CancerResectable SarcomaMetastatic Malignant Neoplasm in the Lung+3 more
Roswell Park Cancer Institute99 enrolled1 locationNCT03965234
Recruiting
Phase 1
Actinium Therapy for Late-stage Aggressive Sarcomas
Advanced Soft Tissue Sarcoma
Ratio Therapeutics, Inc.30 enrolled6 locationsNCT07156565
Recruiting
Phase 1
Phase I Study of Tolododekin Alfa (ANK-101) in Advanced Solid Tumors
Advanced Solid TumorMetastatic Solid TumorNon-small Cell Lung Cancer+6 more
Ankyra Therapeutics, Inc97 enrolled5 locationsNCT06171750
Recruiting
Phase 1
T Cell Membrane-Anchored Tumor-Targeted IL12 -Modified TIL Cell Therapy (attIL12-TIL) for Advanced/Metastatic Soft Tissue and Bone Sarcoma Patients.
Metastatic Soft Tissue Sarcoma
M.D. Anderson Cancer Center40 enrolled1 locationNCT06474676
Recruiting
Phase 1
A Phase I Trial of Combination Gemcitabine and Nab-Sirolimus in Advanced Leiomyosarcomas or Advanced Soft-Tissue Sarcomas With TSC2 or TSC1 Loss-of-function Mutations or Deletions
LeiomyosarcomaSoft Tissue Sarcomas
M.D. Anderson Cancer Center18 enrolled1 locationNCT06308419
Recruiting
Phase 1
Hypofractionated Radiation in Combination With B7-H3-CAR T Cells for Pediatric Patients With Relapsed/Refractory Sarcomas
SarcomaEwing SarcomaChildhood Soft Tissue Sarcoma+2 more
St. Jude Children's Research Hospital42 enrolled1 locationNCT07222735
Recruiting
Phase 1Phase 2
First-in-Human Study of ADCE-D01 in Soft Tissue Sarcoma
Metastatic Soft Tissue SarcomaUnresectable Soft Tissue Sarcoma
Adcendo ApS270 enrolled8 locationsNCT06797999
Recruiting
Phase 1
HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination With Checkpoint Blockade in Patients With Advanced Sarcoma
Soft Tissue SarcomaSarcomaOsteosarcoma+5 more
Baylor College of Medicine25 enrolled1 locationNCT04995003
Recruiting
Phase 1
Zanzalintinib in Combination With Ipilimumab and Nivolumab in Patients With Metastatic Soft Tissue Sarcoma
Metastatic Soft Tissue Sarcoma
Washington University School of Medicine18 enrolled1 locationNCT06968988
Recruiting
Phase 1Phase 2
A Study of MT-4561 in Patients With Various Advanced Solid Tumors
Breast CancerEsophageal CancerGastric Cancer+13 more
Tanabe Pharma America, Inc.27 enrolled6 locationsNCT06943521