Soft Tissue Clinical Trials

216 recruitingLast updated: May 21, 2026

There are 216 actively recruiting soft tissue clinical trials across 45 countries. Studies span Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1. Top locations include Houston, Texas, United States, New York, New York, United States, Lyon, France. Updated daily from ClinicalTrials.gov.


Soft Tissue Trials at a Glance

216 actively recruiting trials for soft tissue are listed on ClinicalTrialsFinder across 6 cities in 45 countries. The largest study group is Phase 2 with 70 trials, with the heaviest enrollment activity in Houston, New York, and Lyon. Lead sponsors running soft tissue studies include M.D. Anderson Cancer Center, Cairo University, and Grupo Espanol de Investigacion en Sarcomas.

Browse soft tissue trials by phase

About Soft Tissue Clinical Trials

Looking for clinical trials for Soft Tissue? There are currently 3 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Soft Tissue trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Soft Tissue clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 216 trials

Recruiting
Phase 1Phase 2

Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma

Recurrent Malignant Solid NeoplasmRefractory Malignant Solid NeoplasmRecurrent Solid Tumor+19 more
St. Jude Children's Research Hospital90 enrolled10 locationsNCT04901702
Recruiting
Phase 1

Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases

Malignant Neoplasm of Bone and Articular CartilageMalignant Neoplasms of Female Genital OrgansMalignant Neoplasms of Independent (Primary) Multiple Sites+7 more
M.D. Anderson Cancer Center44 enrolled1 locationNCT03093909
Recruiting
Phase 1

B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)

Soft Tissue SarcomaMelanomaCarcinoma+13 more
St. Jude Children's Research Hospital48 enrolled1 locationNCT04897321
Recruiting
Phase 3

Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas

Metastatic Dedifferentiated LiposarcomaStage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8Stage IV Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8+3 more
National Cancer Institute (NCI)365 enrolled251 locationsNCT06422806
Recruiting
Phase 1

A Study Evaluating the Safety, Pharmacokinetics and Early Efficacy of AVA6000 in Solid Tumours

Breast CancerUrothelial CarcinomaSoft Tissue Sarcoma+2 more
Avacta Life Sciences Ltd158 enrolled9 locationsNCT04969835
Recruiting
Not Applicable

Study Assessing the Effects of Early Psychiatric Referral on Mental Health and Quality of Life in People With Sarcoma

Soft Tissue SarcomaSarcomaBone Sarcoma
Memorial Sloan Kettering Cancer Center60 enrolled8 locationsNCT06129903
Recruiting
Phase 1Phase 2

Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma

Metastatic Soft Tissue SarcomaMetastatic LeiomyosarcomaAdvanced Soft Tissue Sarcoma+5 more
National Cancer Institute (NCI)74 enrolled1 locationNCT06498648
Recruiting
Phase 2

Testing Atezolizumab With Selinexor in People ≥ 12 Years Old With Alveolar Soft Part Sarcoma, The AXIOM Trial

Metastatic Alveolar Soft Part SarcomaAdvanced Soft Tissue SarcomaAdvanced Alveolar Soft Part Sarcoma+2 more
National Cancer Institute (NCI)27 enrolled13 locationsNCT05333458
Recruiting

Clinical Safety Guidelines for Managing Distal Shoe Complications

Premature loss of primary molarsSpace MaintainerSoft Tissue Inflammation
University of Florida50 enrolled2 locationsNCT07410442
Recruiting
Not Applicable

Assessment of Soft Tissue Thickness Over Zygomatic Implants in Atrophied Maxilla Covered With Buccal Fat Pad vs. Palatal Pedicle Flap

Dental ImplantSoft Tissue Augmentation at Dental ImplantsZygomatic Implants+5 more
Future University in Egypt4 enrolled1 locationNCT07574606
Recruiting

Deep Phenotyping Gait Deficits in Orthopedic Manifestations of Pediatric Cancer Patients

Gait disorderSarcoma,Soft TissueSarcoma, Bone
St. Jude Children's Research Hospital300 enrolled1 locationNCT07502885
Recruiting
Not Applicable

Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials

MelanomaBreast Cancer, NOSCNS Primary Tumor, NOS+9 more
Eastern Cooperative Oncology Group400 enrolled347 locationsNCT05108298
Recruiting
Phase 1

Safety and Efficacy of DIT309 in Advanced Bone and Soft Tissue Sarcomas

Soft Tissue SarcomaOsteosarcoma
Tcelltech Inc.15 enrolled1 locationNCT07052383
Recruiting
Phase 1

A First-In-Human Phase 1 Trial of T-Cell Membrane-Anchored Tumor Targeted Il12 (Attil12)- T-Cell Therapy in Subjects With Advanced/Metastatic Soft Tissue and Bone Sarcoma

Soft Tissue SarcomaBone Sarcoma
M.D. Anderson Cancer Center40 enrolled1 locationNCT05621668
Recruiting
Not Applicable

Spatially Fractionated Radiotherapy Versus Conventional Radiotherapy in the Treatment of Soft Tissue Sarcoma

Soft Tissue Sarcoma (STS)
Shandong Cancer Hospital and Institute106 enrolled1 locationNCT06980259
Recruiting
Phase 1

Novel RNA-lipid Particle (RNA-LP) Vaccine for Anti-PD-1 Antibody Therapy Sensitization

Soft Tissue SarcomaMelanoma
University of Florida18 enrolled1 locationNCT05264974
Recruiting
Phase 2

Pemetrexed, Cisplatin With Soft Tissue Sarcoma

Sarcoma,Soft Tissue
Yonsei University164 enrolled1 locationNCT04605770
Recruiting
Phase 1

Phase I Study of [177Lu]Lu-DFC413 in Patients With Solid Tumors

Triple-Negative Breast CancerColorectal, CancerSoft Tissue Sarcoma+3 more
Novartis Pharmaceuticals180 enrolled7 locationsNCT07261631
Recruiting
Not Applicable

Assessment of Soft Tissue Thickness Following Utilization of Buccal Pad of Fat Versus Platelet-rich Fibrin for Covering Zygomatic Implants: A Randomized Clinical Trial

Soft Tissue Augmentation at Dental Implants
Cairo University24 enrolled1 locationNCT07562334
Recruiting
Phase 4

Adjunctive Hyperbaric Oxygen Treatment for Patients With Necrotizing Soft-Tissue Infection (HOT-NSTI Trial).

Necrotizing Soft Tissue Infection
Ole Hyldegaard1,480 enrolled1 locationNCT07489274