Soft Tissue Clinical Trials

1 recruiting

Frequently Asked Questions

Common questions about Soft Tissue clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 161 trials

Recruiting
Phase 2

Testing Atezolizumab With Selinexor in People ≥ 12 Years Old With Alveolar Soft Part Sarcoma, The AXIOM Trial

Metastatic Alveolar Soft Part SarcomaAdvanced Soft Tissue SarcomaAdvanced Alveolar Soft Part Sarcoma+2 more
National Cancer Institute (NCI)27 enrolled13 locationsNCT05333458
Recruiting
Phase 1Phase 2

Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma

Metastatic Soft Tissue SarcomaMetastatic LeiomyosarcomaAdvanced Soft Tissue Sarcoma+5 more
National Cancer Institute (NCI)74 enrolled1 locationNCT06498648
Recruiting
Phase 3

Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas

Metastatic Dedifferentiated LiposarcomaStage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8Stage IV Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8+3 more
National Cancer Institute (NCI)365 enrolled246 locationsNCT06422806
Recruiting
Not Applicable

Superiority Trial Evaluating Digitalized Information Media for Patients With Advanced Sarcomas Receiving Systemic Treatment.

Sarcoma MetastaticLocally Advanced Soft Tissue Sarcoma
Centre Oscar Lambret377 enrolled11 locationsNCT06211257
Recruiting

Prospective Registry of Histotripsy for Soft Tissue Tumors

Soft Tissue NeoplasmSoft Tissue CancerSoft Tissue Lesion
University of California, San Francisco200 enrolled1 locationNCT07470008
Recruiting
Phase 1Phase 2

Pulmonary Suffusion in Controlling Minimal Residual Disease in Patients With Sarcoma or Colorectal Metastases

Colorectal, CancerResectable SarcomaMetastatic Malignant Neoplasm in the Lung+3 more
Roswell Park Cancer Institute99 enrolled1 locationNCT03965234
Recruiting
Phase 1

Actinium Therapy for Late-stage Aggressive Sarcomas

Advanced Soft Tissue Sarcoma
Ratio Therapeutics, Inc.30 enrolled6 locationsNCT07156565
Recruiting
Not Applicable

Assessment of the Functional Outcome and Quality of Life in Sarcoma Patients

Soft Tissue SarcomaBone Sarcoma
Universitaire Ziekenhuizen KU Leuven60 enrolled1 locationNCT05051059
Recruiting
Phase 1

Phase I Study of [177Lu]Lu-DFC413 in Patients With Solid Tumors

Triple-Negative Breast CancerColorectal, CancerSoft Tissue Sarcoma+3 more
Novartis Pharmaceuticals180 enrolled5 locationsNCT07261631
Recruiting
Phase 2

IVIM & OLINK in Sarcoma

Soft Tissue Sarcoma
University Health Network, Toronto145 enrolled1 locationNCT05950594
Recruiting
Phase 2

A Clinical Study to Investigate the Efficacy of Intratumoral Tigilanol Tiglate in Soft Tissue Sarcoma

Soft Tissue Sarcoma
QBiotics Group Limited40 enrolled1 locationNCT05755113
Recruiting
Not Applicable

Neoadjuvant Irradiation of Extremity Soft Tissue Sarcoma With Ions

Soft Tissue Sarcoma
University Hospital Heidelberg42 enrolled1 locationNCT04946357
Recruiting
Not Applicable

Phase II Study of 5-Day Hypofractionated Preoperative Radiation Therapy for Soft Tissue Sarcomas: Expansion Cohort

Recurrent Adult Soft Tissue Sarcoma
Jonsson Comprehensive Cancer Center51 enrolled1 locationNCT02701153
Recruiting
Not Applicable

Neoadjuvant Irradiation of Retroperitoneal Soft Tissue Sarcoma With Ions Retro-Ion

Sarcoma,Soft Tissue
University Hospital Heidelberg64 enrolled1 locationNCT04219202
Recruiting
Phase 1

Phase I Study of Tolododekin Alfa (ANK-101) in Advanced Solid Tumors

Advanced Solid TumorMetastatic Solid TumorNon-small Cell Lung Cancer+6 more
Ankyra Therapeutics, Inc97 enrolled5 locationsNCT06171750
Recruiting
Phase 2

Metformin Hydrochloride in Combination With Standard of Care Systemic Therapy in Previously Untreated Advanced Unresectable or Metastatic Soft Tissue Sarcoma

Sarcoma,Soft TissueSarcoma Metastatic
Wake Forest University Health Sciences50 enrolled2 locationsNCT07291297
Recruiting
Phase 2

Evaluating the Impact of Limited Compared With Intense Post-Operative Surveillance on Patient-Reported Outcomes in Patients With Stage II-III Soft Tissue Sarcoma of the Trunk and Extremities

Stage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8Stage II Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8Stage IIIA Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8+1 more
M.D. Anderson Cancer Center227 enrolled1 locationNCT04751409
Recruiting
Phase 2

BAL Fluid Biomarkers in Sarcoma

Soft Tissue Sarcoma (STS)Bronchoalveolar Lavage (BAL)Bronchoalveolar Lavage Fluid
University Health Network, Toronto70 enrolled1 locationNCT06815666
Recruiting
Not Applicable

Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials

MelanomaBreast Cancer, NOSCNS Primary Tumor, NOS+9 more
Eastern Cooperative Oncology Group400 enrolled347 locationsNCT05108298
Recruiting
Not Applicable

INPWT on Wound Complications & Clinical Outcomes After Lower Extremity Sarcoma Surgery Preop Radiation Therapy Patients

Soft Tissue SarcomaWound Complication
Dr. J. Werier291 enrolled2 locationsNCT03175718