Soft Tissue Clinical Trials

231 recruitingLast updated: July 25, 2026

There are 231 actively recruiting soft tissue clinical trials across 47 countries. Studies span Phase 2, Not Applicable, Phase 1, Phase 3, Early Phase 1, Phase 4. Top locations include Houston, Texas, United States, New York, New York, United States, Lyon, France. Updated daily from ClinicalTrials.gov.


Soft Tissue Trials at a Glance

231 actively recruiting trials for soft tissue are listed on ClinicalTrialsFinder across 6 cities in 47 countries. The largest study group is Phase 2 with 74 trials, with the heaviest enrollment activity in Houston, New York, and Lyon. Lead sponsors running soft tissue studies include M.D. Anderson Cancer Center, Cairo University, and Sun Yat-sen University.

Browse soft tissue trials by phase

Treatments under study

About Soft Tissue Clinical Trials

Looking for clinical trials for Soft Tissue? There are currently 4 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Soft Tissue trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Soft Tissue clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 231 trials

Recruiting
Phase 2

Testing Atezolizumab With Selinexor in People ≥ 12 Years Old With Alveolar Soft Part Sarcoma, AXIOM Trial

Metastatic Alveolar Soft Part SarcomaAdvanced Soft Tissue SarcomaAdvanced Alveolar Soft Part Sarcoma+2 more
National Cancer Institute (NCI)27 enrolled13 locationsNCT05333458
Recruiting

Colorectal Resections in Patients With Retroperitoneal Sarcoma

Sarcoma,Soft TissueRetroperitoneal Sarcoma
Heidelberg University120 enrolled16 locationsNCT06943612
Recruiting
Phase 2

Assessment of the Long-term Efficacy of Moderately Hypofractionated Neoadjuvant Radiotherapy Soft Tissue Sarcoma in the Limbs or Trunk Wall

Soft Tissue Sarcoma AdultSoft Tissue Sarcoma (Excluding GIST)Soft Tissue Sarcoma of the Trunk and Extremities+1 more
Centre Oscar Lambret135 enrolled1 locationNCT07507773
Recruiting
Phase 2

Metformin Hydrochloride in Combination With Standard of Care Systemic Therapy in Previously Untreated Advanced Unresectable or Metastatic Soft Tissue Sarcoma

Sarcoma,Soft TissueSarcoma Metastatic
Wake Forest University Health Sciences50 enrolled2 locationsNCT07291297
Recruiting
Phase 1

Novel RNA-lipid Particle (RNA-LP) Vaccine for Anti-PD-1 Antibody Therapy Sensitization

Soft Tissue SarcomaMelanoma
University of Florida18 enrolled1 locationNCT05264974
Recruiting
Not Applicable

Improving Adolescent and Young Adult Self-Reported Data in ECOG-ACRIN Trials

MelanomaBreast Cancer, NOSCNS Primary Tumor, NOS+9 more
Eastern Cooperative Oncology Group400 enrolled347 locationsNCT05108298
Recruiting
Phase 1Phase 2

Trial of Single Protein Encapsulated Doxorubicin, SPEDOX-6 in Advanced Malignancies

Triple-Negative Breast CancerOvarian CancerCervical Cancer+3 more
University of California, Irvine67 enrolled1 locationNCT07064018
Recruiting
Phase 1

A Phase I Study of Pazopanib in Combination With Trabectedin, Ipilimumab and Nivolumab (TraPIN) in Pediatric and Young Adult Patients With Recurrent Soft Tissue Sarcomas

Soft Tissue Sarcomas
M.D. Anderson Cancer Center18 enrolled1 locationNCT07444619
Recruiting
Phase 1

Actinium Therapy for Late-stage Aggressive Sarcomas

Advanced Soft Tissue Sarcoma
Ratio Therapeutics, Inc.30 enrolled6 locationsNCT07156565
Recruiting
Phase 1

Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases

Malignant Neoplasm of Bone and Articular CartilageMalignant Neoplasms of Female Genital OrgansMalignant Neoplasms of Independent (Primary) Multiple Sites+7 more
M.D. Anderson Cancer Center44 enrolled1 locationNCT03093909
Recruiting
Phase 3

Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas

Metastatic Dedifferentiated LiposarcomaStage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8Stage IV Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8+3 more
National Cancer Institute (NCI)365 enrolled257 locationsNCT06422806
Recruiting

Myriad™ Augmented Soft Tissue Reconstruction Registry

pressure injurypilonidal sinusHidradenitis Suppurativa+4 more
Aroa Biosurgery Limited800 enrolled15 locationsNCT05243966
Recruiting
Phase 1

A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic Solid Tumors

Gastric CancerColon CancerTriple Negative Breast Cancer(TNBC)+8 more
SHY Therapeutics30 enrolled3 locationsNCT07705334
Recruiting
Phase 1Phase 2

Atezolizumab Plus Tivozanib in Immunologically Cold Tumor Types

Breast CancerOvarian CancerProstate Cancer+6 more
University of Florida29 enrolled1 locationNCT05000294
Recruiting

Clinical Safety Guidelines for Managing Distal Shoe Complications

Premature loss of primary molarsSpace MaintainerSoft Tissue Inflammation
University of Florida50 enrolled2 locationsNCT07410442
Recruiting

Galvanize Prospective/Retrospective Pulsed Electric Field Device Registry

Soft Tissue Lesion
Galvanize Therapeutics, Inc.1,000 enrolled11 locationsNCT05851430
Recruiting
Phase 2

Pegylated Liposomal Doxorubicin (PLD) Versus Active Surveillance for Advanced Soft Tissue Sarcoma Patients Who Had Controlled Disease After Standard Anthracycline-based Treatment (MELODY)

Advanced Soft Tissue Sarcoma
National Health Research Institutes, Taiwan81 enrolled7 locationsNCT06981637
Recruiting
Not Applicable

Impact of Abutment Screw Torque on Marginal Bone Loss

Soft Tissues According to the Abutment TorqueMicroleakage Accordint to the Abutment TorquePROMS According to the Abutment Torque+1 more
University of Valencia30 enrolled1 locationNCT07234552
Recruiting
Not Applicable

Fluorescence-Guided Optimization of Sarcoma Margins

SarcomaSoft Tissue Sarcoma of the Trunk and Extremities
University of Aarhus90 enrolled2 locationsNCT07134192
Recruiting
Phase 1

Zanzalintinib in Combination With Ipilimumab and Nivolumab in Patients With Metastatic Soft Tissue Sarcoma

Metastatic Soft Tissue Sarcoma
Washington University School of Medicine18 enrolled1 locationNCT06968988