Phase 2 Squamous Cell Carcinoma of the Head and Neck Clinical Trials
14 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–14 of 14 trials
Recruiting
Phase 2
Phase II Trial of Neoadjuvant Chemotherapy (NAC) Alone or in Combination With Immunotherapy Vaccine PRGN-2009 in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal (Head and Neck) Cancer
Squamous Cell Carcinoma of the Head and NeckDrug TherapyOropharynx+2 more
National Cancer Institute (NCI)70 enrolled1 locationNCT06223568
Recruiting
Phase 2
5-Fluorouracil Response and Optimization STudy (The FROST Trial)
Squamous Cell Carcinoma of Head and NeckMetastatic Squamous Cell CarcinomaRecurrent Squamous Cell Carcinoma of the Head and Neck
Washington University School of Medicine46 enrolled1 locationNCT07419464
Recruiting
Phase 2
Pembrolizumab + N-803 Alone or in Combination With PD-L1 t-haNK Cells for Resectable Head and Neck Squamous Cell Carcinoma
Stage II Squamous Cell Carcinoma of the Head and NeckStage III Squamous Cell Carcinoma of the Head and NeckStage IV Squamous Cell Carcinoma of the Head and Neck
National Cancer Institute (NCI)40 enrolled1 locationNCT06161545
Recruiting
Phase 2
Neoadjuvant Ficerafusp Alfa With Pembrolizumab in Resectable SCC
Head and Neck Squamous Cell Carcinoma (HNSCC)Squamous Cell Carcinoma of the Head and Neck
Dana-Farber Cancer Institute32 enrolled2 locationsNCT07465276
Recruiting
Phase 1Phase 2
Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors
Anatomic Stage III Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8Metastatic Triple-Negative Breast Carcinoma+97 more
Mayo Clinic132 enrolled1 locationNCT05269381
Recruiting
Phase 2
Pembrolizumab for the Treatment of Locally Advanced and/or Recurrent Orbital or Periocular Cutaneous Squamous Cell Carcinoma
Recurrent Cutaneous Squamous Cell Carcinoma of the Head and NeckLocally Advanced Cutaneous Squamous Cell Carcinoma of the Head and NeckStage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8
University of Michigan Rogel Cancer Center22 enrolled1 locationNCT06580054
Recruiting
Phase 2
Intensity Modulated Proton or X-Ray Therapy After Surgery for Treatment of Head and Neck Cancer, the HEADLIGHT Study
Head and Neck CarcinomaSalivary Gland CarcinomaMetastatic Malignant Neoplasm in the Lymph Nodes+9 more
Mayo Clinic174 enrolled9 locationsNCT05075980
Recruiting
Phase 2
Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program
Urothelial CarcinomaEsophageal CarcinomaHepatocellular Carcinoma+28 more
Mayo Clinic50 enrolled1 locationNCT06265285
Recruiting
Phase 2
Phase 2 Pragmatic Trial of Sentinel Lymph Node Biopsy (SLNB) in Patients With Clinically Node-Negative (cN0), High-Risk Cutaneous Squamous Cell Carcinoma (cSCC) of the Head and Neck
Cutaneous Squamous Cell Carcinoma of the Head and NeckClinically Node-Negative (cN0)High-Risk Cutaneous Squamous Cell Carcinoma (cSCC) of the Head and Neck
University of California, Davis24 enrolled1 locationNCT06990737
Recruiting
Phase 2
Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors
Non-small Cell Lung CancerMetastatic MelanomaSquamous Cell Carcinoma of the Head and Neck
Iovance Biotherapeutics, Inc.245 enrolled45 locationsNCT03645928
Recruiting
Phase 2
Preoperative Pembrolizumab and Chemotherapy in Resectable, Recurrent HNSCC
Head and Neck CancerHead and Neck Squamous Cell CarcinomaRecurrent Head and Neck Squamous Cell Carcinoma+2 more
Dana-Farber Cancer Institute28 enrolled2 locationsNCT05726370
Recruiting
Phase 2
Towards Cure Via Only Ultra-short ICB in CSCC
Cutaneous Squamous Cell CancerCutaneous Squamous Cell CarcinomaCutaneous Squamous Cell Carcinoma (CSCC)+1 more
The Netherlands Cancer Institute41 enrolled5 locationsNCT06823479
Recruiting
Phase 2
Fluorescence-guided Surgery Using cRGD-ZW800-1 in Oral Cancer
Squamous Cell Carcinoma of the Head and NeckOral CancerSquamous Cell Carcinoma of the Oral Cavity
Erasmus Medical Center28 enrolled1 locationNCT04191460
Recruiting
Phase 2
Neoadjuvant Pembrolizumab in Cutaneous Squamous Cell Carcinoma
Head and Neck CancerCutaneous Squamous Cell Carcinoma of the Head and Neck
Queensland Health27 enrolled3 locationsNCT05025813