Phase 2 Thalassemia Clinical Trials
16 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–16 of 16 trials
Recruiting
Phase 1Phase 2
Partial Stem Cell Transplant for Sickle Cell Disease From Matched Donors
Beta-ThalassemiaSickle Cell Disease
National Heart, Lung, and Blood Institute (NHLBI)90 enrolled1 locationNCT07599176
Recruiting
Phase 2
A Study of Immune Suppression Treatment for People With Sickle Cell Disease or β-Thalassemia Who Are Going to Receive an Allogeneic Hematopoietic Cell Transplantation (HCT)
Sickle Cell DiseaseThalassemiaThalassemia (beta)
Memorial Sloan Kettering Cancer Center24 enrolled6 locationsNCT05736419
Recruiting
Phase 2
Targeting the Pathophysiology of Sickle Cell-Related Kidney Disease Using the SGLT2 Inhibitors, Empagliflozin
AlbuminuriaSickle Cell Anemia (HbSS, or HbSβ-thalassemia0)
University of Illinois at Chicago20 enrolled1 locationNCT07175051
Recruiting
Phase 1Phase 2
ALS20-101 Lentiviral Gene Therapy for Beta Thalassemia
Beta-Thalassemia
Children's Hospital of Philadelphia12 enrolled1 locationNCT06364774
Recruiting
Phase 2
A Study to Test the Safety, Tolerability, and Efficacy of an Antibody, REGN7999, Injected Under the Skin for the Treatment of Iron Overload in Adult Participants With Non-Transfusion Dependent β-thalassemia, Using MRI Scans to Measure Iron Levels in the Body
Non-Transfusion Dependent Beta-Thalassemia (NTDT)
Regeneron Pharmaceuticals95 enrolled26 locationsNCT06421636
Recruiting
Phase 2
A Study of Safety and Efficiency of AND017 in Patients With β-thalassemia
Thalassemia
Kind Pharmaceuticals LLC64 enrolled5 locationsNCT06302491
Recruiting
Phase 2
Evaluating the Clinical Efficacy and Safety of Luspatercept Combined With Thalidomide in the Treatment of β-TDT Patients
Transfusion-dependent β-thalassemia Patients
Rongrong Liu78 enrolled8 locationsNCT07338344
Recruiting
Phase 2
Study of Safety & PK of Luspatercept (ACE-536) in Pediatric Participants With Beta (β)-Thalassemia
Beta-Thalassemia
Celgene99 enrolled26 locationsNCT04143724
Recruiting
Phase 1Phase 2
An Open-label Study of a Gene Therapy Product (Vebeglogene Autotemcel) in Transfusion Dependent Beta-Thalassemia
Beta-Thalassemia
Lantu Biopharma6 enrolled2 locationsNCT06308159
Recruiting
Phase 2
A Trial Testing SP-420 in Subjects With Transfusion-dependent β-thalassemia or Low-risk Myelodysplastic Syndromes
Myelodysplastic SyndromeBeta Thalassemia Major Anemia
Pharmacosmos A/S90 enrolled1 locationNCT05693909
Recruiting
Phase 2
AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion
Hodgkin LymphomaNon-Hodgkin LymphomaAcute Leukemia+6 more
Mitchell Cairo20 enrolled1 locationNCT04099966
Recruiting
Phase 1Phase 2
T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other Anemias
Diamond-Blackfan AnemiaSickle Cell Anemiabeta thalassemia major
Paul Szabolcs5 enrolled1 locationNCT03653338
Recruiting
Phase 2
Unraveling the Impact of Thalidomide at Diverse Doses in Transfusion Dependent Beta Thalassemia
Genetic DiseaseFetal HemoglobinThalassemia Major
National Institute of Blood and Marrow Transplant (NIBMT), Pakistan54 enrolled1 locationNCT06490627
Recruiting
Phase 1Phase 2
Β-Thalassemia Treatment with KL003 Cell Injection
Transfusion Dependent Beta-Thalassemia
Kanglin Biotechnology (Hangzhou) Co., Ltd.41 enrolled2 locationsNCT06280378
Recruiting
Phase 2
Evaluation of Recombinant Humanized Anti-CD25 Monoclonal Antibody for Preventing Graft-versus-host Disease After Haploidentical/matched Unrelated Donor Hematopoietic Stem Cell Transplantation in Patients with Transfusion-dependent Thalassemia
Transfusion Dependent Thalassemia
Rongrong Liu396 enrolled5 locationsNCT06657391
Recruiting
Phase 1Phase 2
Thal-Fabs: Reduced Toxicity Conditioning for High Risk Thalassemia
Thalassemia in Children
The Hospital for Sick Children20 enrolled1 locationNCT05426252