Phase 1 Type 1 Diabetes Clinical Trials
18 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–18 of 18 trials
Recruiting
Phase 1
Safety, Pharmacokinetics, and Pharmacodynamics of MTX-101 in Healthy Adults and Patients
Healthy VolunteersType 1 Diabetes
Mozart Therapeutics Australia Pty Ltd96 enrolled4 locationsNCT06324604
Recruiting
Phase 1Phase 2
A Randomized Phase 1/2 Trial of Low Dose Anti-thymocyte Globulin (ATG) With Subsequent Adalimumab or Verapamil in New Onset Type 1 Diabetes
Type 1 DiabetesNew Onset
City of Hope Medical Center120 enrolled11 locationsNCT07061574
Recruiting
Phase 1Phase 2
CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)
Type 1 DiabetesType 1 Diabetes MellitusType 1 Diabetes Mellitis+7 more
COUR Pharmaceutical Development Company, Inc.72 enrolled31 locationsNCT06783309
Recruiting
Phase 1Phase 2
Safety, Tolerability, and Efficacy of Immunomodulation With A Monoclonal Antibody Against CD40L in Combination With Transplanted Islet Cells in Adults With Brittle Type 1 Diabetes Mellitus (T1D)
Type 1 Diabetes Mellitus
University of Chicago70 enrolled1 locationNCT06305286
Recruiting
Phase 1Phase 2
A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus
Metabolic DiseaseDiabetes Mellitus, Type 1Type 1 Diabetes+14 more
Otsuka Pharmaceutical Factory, Inc.13 enrolled1 locationNCT06575426
Recruiting
Phase 1Phase 2
Safety and Efficacy of CELZ-201 in Patients With Recent Onset Type 1 Diabetes
Diabetes Mellitus, Type 1Type 1 Diabetes
Creative Medical Technology Holdings Inc18 enrolled1 locationNCT05626712
Recruiting
Phase 1
A Study of GNTI-122 in Adults Recently Diagnosed With T1D
Type 1 Diabetes MellitusType 1 Diabetes (T1D)
GentiBio, Inc16 enrolled10 locationsNCT06919354
Recruiting
Phase 1
A Study of LY3938577 in Healthy Participants and Participants With Type 1 Diabetes Mellitus (T1DM)
HealthyType 1 Diabetes Mellitus
Eli Lilly and Company118 enrolled1 locationNCT06280703
Recruiting
Phase 1
A Single Bolus, 12-hour Euglycemic Clamp Study of the Safety, Pharmacokinetics (PK) and Glucodynamics (GD) of Intraperitoneal (IP) Portal Insulin U-500
Type 1 Diabetes
Portal Diabetes, Inc.25 enrolled1 locationNCT07341373
Recruiting
Phase 1
Subcutaneous Pharmacokinetic Evaluation of Monomeric Insulin and Lyumjev in Adults With Type 1 Diabetes
Diabetes Mellitus, Type 1Type 1 Diabetes Mellitus
Stanford University20 enrolled1 locationNCT07090824
Recruiting
Phase 1
Clamp Study to Estimate the Relative Potency of GZR33 Versus Insulin Degludec at Steady State
Type 1 Diabetes Mellitis
Gan and Lee Pharmaceuticals, USA12 enrolled2 locationsNCT07242664
Recruiting
Phase 1Phase 2
A Phase I/II Trial to Preserve Residual Insulin Secretion in Children With Recent Onset Type 1 Diabetes by Giving Verapamil
Type 1 Diabetes
Johnny Ludvigsson36 enrolled2 locationsNCT07199946
Recruiting
Phase 1
MS-553 in Diabetic Retinopathy Patients With Central Involved Macular Edema
Diabetic RetinopathyDiabetic Macular EdemaMacular Edema+2 more
Shenzhen MingSight Relin Pharmaceuticals Co., Ltd.45 enrolled3 locationsNCT04187443
Recruiting
Phase 1Phase 2
Denosumab for Type 1 Diabetes
Type 1 Diabetes
City of Hope Medical Center45 enrolled3 locationsNCT06524960
Recruiting
Phase 1
MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes
Cardiovascular DiseasesEndothelial DysfunctionType 1 Diabetes+2 more
Kalie Tommerdahl60 enrolled2 locationsNCT05065372
Recruiting
Phase 1
Efficacy of Adipose Tissue Derived Stem Cells for the Treatment of Diabetic Foot Ulcers
Diabetes MellitusDiabetic Foot UlcerDiabetic Foot+8 more
University of the Punjab28 enrolled1 locationNCT05610865
Recruiting
Phase 1
Immunotherapy with Autologous Tregs in T1DM
Type 1 Diabetes Mellitus
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School20 enrolled1 locationNCT06708780
Recruiting
Phase 1Phase 2
Combination Adjunctive Therapy to Address Multiple Metabolic Imbalances in Type 1 Diabetes
Type 1 Diabetes
University of California, San Diego24 enrolled1 locationNCT05696366