DORADO – Fixed Doses of Darusentan as Compared to Placebo in Resistant Hypertension

This study is testing a new experimental drug called darusentan to see if it can lower blood pressure in people whose high blood pressure cannot be controlled even with four or more blood pressure medications. This type of hard-to-treat high blood pressure is called resistant hypertension. Participants will be randomly assigned to take one of three doses of darusentan or a sugar pill (placebo) for 14 weeks to see which dose works best and is safe. You may be eligible if: - You are between 35 and 80 years old - You have high systolic (top number) blood pressure that stays high despite taking four or more blood pressure medications at full doses, including a water pill (diuretic) - If you have diabetes or kidney disease, your systolic blood pressure is 130 mmHg or higher - If you do not have those conditions, your systolic blood pressure is 140 mmHg or higher - Women must be post-menopausal (at least 2 years) or have had surgery that prevents pregnancy You may NOT be eligible if: - Your systolic blood pressure is 180 mmHg or higher, or diastolic (bottom number) is 110 mmHg or higher - You have had a heart attack, unstable chest pain, or stroke in the past 6 months - You have certain heart rhythm problems or a pacemaker - You have Type 1 diabetes - You are on dialysis or have had a kidney transplant - You have been diagnosed with cancer in the past 3 years - You have untreated or poorly managed sleep apnea - You work night shifts - You are currently in another clinical trial Talk to your doctor about whether this trial might be right for you.