RecruitingNot ApplicableNCT03875625

Change of Adipose Tissues and Triglyceride After Bariatric Surgery or Life-style Intervention

Change of Adipose Tissues and Triglyceride in Obese Patients With Non-alcoholic Fatty Liver Disease After Bariatric Surgery or Life-style Intervention

Sponsor

Chinese University of Hong Kong

Enrollment

80 participants

Start Date

Apr 1, 2019

Study Type

INTERVENTIONAL

Conditions

Diabetes Mellitus Insulin Resistance Metabolic Disease Non-Alcoholic Fatty Liver Disease Obesity, Morbid Brown Fat Abdominal Subcutaneous Fat

Summary

The study is aimed * To quantify the change of adipose tissues, triglyceride in liver and pancreas and cholesterol after lifestyle intervention or bariatric surgery. * To test the hypothesis that Brown fat is an independent biomarker for the development of Non Alcoholic Fat Liver Disease (NAFLD) * To study the association among Brown fat, NAFLD and obesity.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria3

BMI ≥ 25-30 kg/m2
BMI ≥ 30 kg/m2 with Metabolic syndrome
BMI ≥ 35 kg/m2 for morbid obesity

Exclusion Criteria5

Other kind of hepatic diseases
Under medications known to affect liver fat
Waist circumference ≥ 150 cm
Weight ≥ 250 kg
MRI contraindications

Interventions

PROCEDUREBariatric surgery

Use of the normal bariatric surgery procedures commonly conducted in our hospital, such as: Laparoscopic Roux-en-Y gastric bypass (RYGB) and Laparoscopic sleeve gastrectomy (LSG)

BEHAVIORALDietitian led life style modification intervention

Intensive 6 months life style changes supervised by diatitians.

BEHAVIORALConventional care (control)

receive routine care