RecruitingNot ApplicableNCT03875625

Change of Adipose Tissues and Triglyceride After Bariatric Surgery or Life-style Intervention

Change of Adipose Tissues and Triglyceride in Obese Patients With Non-alcoholic Fatty Liver Disease After Bariatric Surgery or Life-style Intervention


Sponsor

Chinese University of Hong Kong

Enrollment

80 participants

Start Date

Apr 1, 2019

Study Type

INTERVENTIONAL

Conditions

Summary

The study is aimed * To quantify the change of adipose tissues, triglyceride in liver and pancreas and cholesterol after lifestyle intervention or bariatric surgery. * To test the hypothesis that Brown fat is an independent biomarker for the development of Non Alcoholic Fat Liver Disease (NAFLD) * To study the association among Brown fat, NAFLD and obesity.


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how fat tissue stored in and around the liver and organs changes after weight-loss surgery versus structured lifestyle changes (diet and exercise). Researchers want to understand which approach more effectively reduces the metabolic harm caused by excess body fat, especially triglycerides and liver fat. **You may be eligible if...** - You are overweight or obese — BMI of 25–30 with metabolic syndrome, BMI over 30 generally, or BMI over 35 for severe obesity - You are planning to have weight-loss surgery or participate in a structured lifestyle program **You may NOT be eligible if...** - You have liver diseases unrelated to weight (such as hepatitis) - You are taking medications known to affect liver fat - Your waist circumference is 150 cm or more - Your weight is 250 kg or more - You have a reason you cannot have an MRI scan such as metal implants Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREBariatric surgery

Use of the normal bariatric surgery procedures commonly conducted in our hospital, such as: Laparoscopic Roux-en-Y gastric bypass (RYGB) and Laparoscopic sleeve gastrectomy (LSG)

BEHAVIORALDietitian led life style modification intervention

Intensive 6 months life style changes supervised by diatitians.

BEHAVIORALConventional care (control)

receive routine care


Locations(1)

The Chinese University of Hong Kong, Prince of Wale Hospital

Hong Kong, Shatin, Hong Kong

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NCT03875625


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