RecruitingNCT05277558

Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D)

Brain Health Across the Metabolic Continuum in Youth at Risk for Type 2 Diabetes (T2D)

Sponsor

Washington University School of Medicine

Enrollment

117 participants

Start Date

May 24, 2022

Study Type

OBSERVATIONAL

Conditions

Insulin Resistance Cognitive Decline Inflammation Obesity, Childhood Type 2 Diabetes Mellitus in Obese Type2 Diabetes Dysglycemia Microvascular Complications Brain Structure Diabetes in Adolescence Overweight, Childhood

Summary

Investigators propose to study youth across the spectrum of body mass index (BMI) and dysglycemia. This approach will allow investigators to disentangle the relationship of key features of type 2 diabetes (T2D) risk (e.g. obesity) with intermediary physiologic changes (e.g. insulin resistance, inflammation, β-cell dysfunction and dysglycemia) that pose a risk for the brain. Investigators will determine which of these factors are most associated with differences in brain structure and function among groups, over time, and how these effects differ from normal neurodevelopment.

Eligibility

Min Age: 12 YearsMax Age: 17 Years

Plain Language Summary

Simplified for easier understanding

This study uses brain MRI and cognitive testing to investigate how obesity and risk for type 2 diabetes may affect brain health in teenagers. **You may be eligible if...** - You are 12–17 years old at your first visit (up to 19 at a second visit) - You are at Tanner stage II or above (entering or in puberty) - You are otherwise healthy except for obesity - You weigh under 450 lbs (MRI scanner limit) - You are able to lie still in an MRI and complete cognitive testing - You are fluent in English **You may NOT be eligible if...** - You have syndromic obesity (a genetic or hormonal cause) - You have had bariatric surgery - You have been on insulin for type 2 diabetes, or on metformin for more than 6 months - You have metal in your body, a pacemaker, braces, or claustrophobia - You have a neurological condition (seizures, stroke, or brain injury) - You take ADHD medication - You were born premature (before 36 weeks) or had significant complications at birth Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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