RecruitingPhase 1Phase 2NCT05408559

Prevention of Age-associated Cardiac and Vascular Dysfunction Using Avmacol ES

Prevention of Age-associated Cardiac and Vascular Dysfunction Through Nrf2 Signaling Using the Nutritional Supplement Sulforaphane

Sponsor

Texas Tech University Health Sciences Center

Enrollment

200 participants

Start Date

Jul 1, 2022

Study Type

INTERVENTIONAL

Conditions

Diastolic Dysfunction Systolic Dysfunction Diastolic Heart Failure

Summary

Our local IRB approved clinical studies seeking proof of principle for the hypothesis that SFN can be safely administered to humans at doses sufficient to protect age-associated cardiac dysfunctions. Beneficial effects of SFN-therapy will be assessed by Pre- and post-intervention echocardiography, and exercise endurance at 0 and 24 weeks. Peripheral blood cells from treated and control subjects will be compared for mitochondrial respiratory function, oxidative damage, pro-inflammatory cytokines, and expression of antioxidant \& anti-electrophile genes.

Eligibility

Min Age: 60 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a broccoli-derived supplement called Avmacol ES can improve heart and blood vessel health in older adults who have heart failure with preserved ejection fraction (HFpEF) — a condition where the heart pumps normally but is too stiff to fill properly. **You may be eligible if...** - You are over 60 years old - You have been diagnosed with HFpEF (heart failure with a normal pumping function, 50% or higher) - You are able to walk more than 500 feet - You are willing to stop taking antioxidant supplement pills during the study **You may NOT be eligible if...** - You have an active cancer diagnosis - You cannot read or understand English well enough to complete the SF-36 questionnaire - You are already taking antioxidant supplements - You have lung or other conditions that limit your ability to walk - You require supplemental oxygen Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGSulforaphane

Caplets containing SFN-rich broccoli sprout extracts or placebo caplets containing microcrystalline cellulose will be obtained from from Nutramax Labs.